Protein Alignment RhoGEF3 and arhgef37

DIOPT Version :9

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: XP_005173214.1
• Gene: arhgef37 / 101883655
• ZFINID: ZDB-GENE-100514-3
• Length: 709
• Species: Danio rerio
• Alignment Length: 610
• Identity: 126/610 - (20%)
• Similarity: 198/610 - (32%)
• Gaps: 221/610 - (36%)

  Fly  2957 RAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQP 3021
            |.||:||||.|..|:.:                           |:.||
Zfish    43 RVAAEEAAARERAAQRQ---------------------------LMAIE---------------- 64

  Fly  3022 DHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKF 3086
                        |::.||.||:|.| .||...:.:..:::....|| :..:|.:|..:.:...:.
Zfish    65 ------------EMVHTEKNYLKHL-QICTVTINSNLQKLQPPPPN-LENMFQHIDEVMEVSSRL 115

  Fly  3087 LEALRRGIEQNQVAKVFLKMHKGFL--------CYSTYCNAYPRALIELETYDRVKDAR-----T 3138
            |..|.:...|:...|....:...||        .|..|...| ..:..||...:.|:|.     .
Zfish   116 LSLLDQAQMQHSDPKYLETLCDSFLSLSQDIEMAYKEYLANY-NNITALENSYKQKEALWMEMVR 179

  Fly  3139 ILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYE 3203
            |:::.....|.:  .||..|:.|||||.||||....|.|           .||....|
Zfish   180 IIKSSAPDVNAS--TLSFFLVMPVQRIARYPLLFQTIQK-----------HTDPQHPA------- 224

  Fly  3204 QLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSE-----------------------TIAR 3245
                    .|:.:.|.:.|::    |...:||.||..|                       :||:
Zfish   225 --------YPELEHTAHTAIQ----INCRINEYKRFREVADKYKKTENLTIKDKLNRLSGHSIAK 277

  Fly  3246 HQASFQNF---------------------------KG-PPLH------LHSARFFL-------QV 3269
            ..|.|..:                           :| ..||      ||..:.||       .:
Zfish   278 KTARFSQYIKHETGIVPKLKDEEFDALAGFFFVLERGVSELHDNLLTYLHHLQRFLSCRPEEADL 342

  Fly  3270 DATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVVNVRDGKMFGHTIKNS 3334
            |...:|..|::...|:.|  .|.:|...:  ||    .|..:|.....:..:..|.      :|.
Zfish   343 DLEGEKTALFSKEITVAL--RQWIYPSYE--KR----LKTLVFKPLSSLRELMAGP------RNL 393

  Fly  3335 LRIYSESRDKWYD-----------FSFRSANRKHRFLSTLALER--QFGGKALYV--SEMTGFEY 3384
            :|   :.:||..|           |..::....::.::||.|..  ||.||||.:  :.:..|..
Zfish   394 IR---KRQDKLLDYEPIEEKSNLTFEEQAIANTYKTMNTLLLNELPQFNGKALQLMWAALEAFSV 455

  Fly  3385 NYEERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAKS--------TSRLCETLPKKSQSRDG 3441
            .          |.|......:|||..|   ..||.|..::        ||.|..:...:|..| .
Zfish   456 L----------QRDLATDMEQLATSFT---HQLPHSYLEAGDFWKWAETSVLEGSWRMESLCR-S 506

  Fly  3442 ISSAENSQIVTTTSTGSLGRRHFGN 3466
            :....|:.||...:|.|..|..:.|
Zfish   507 VQDELNAPIVQALNTVSKKRLMYLN 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	49/216 (23%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	36/209 (17%)
		PH	<3285..3363	CDD:278594	14/88 (16%)
arhgef37	XP_005173214.1	RhoGEF	62..243	CDD:306973	51/243 (21%)
		BAR_DNMBP	295..481	CDD:153273	44/215 (20%)
		SH3	539..592	CDD:327375
		SH3	640..694	CDD:327375

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810