Protein Alignment RhoGEF3 and Plekhg2

DIOPT Version :9

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: XP_006539499.1
• Gene: Plekhg2 / 101497
• MGIID: 2141874
• Length: 1366
• Species: Mus musculus
• Alignment Length: 592
• Identity: 147/592 - (24%)
• Similarity: 220/592 - (37%)
• Gaps: 142/592 - (23%)

  Fly  2937 PKEFVRIIHCPETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTL 3001
            ||..:| :.|        .|:....:.||...|          |.||.|..|..:.....|:.:|
Mouse    11 PKPSLR-LGC--------GHQGEVCDCAAVSDT----------PTAAQAATTMASPRGSGSSTSL 56

  Fly  3002 IVI--ESPPTP--SAPSVDFVAQPDHSTIIR-----------------RSAVRELLDTEVNYVKL 3045
            ..:  |..|:|  ||...:.:.:|.    ||                 ....||:::||..||:.
Mouse    57 STVGSEGDPSPACSASRPEPLPEPP----IRLHLLPVGIQGSVKPSRLERVAREIVETERAYVRD 117

  Fly  3046 LAAICDGYL-PAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQNQVAKVFLKMHKG 3109
            |.:|.:.|| |.|..|....:...:..:|:||..||:|..:.||.|........:|:.|::..:.
Mouse   118 LRSIVEDYLGPLMDGRALGLNMEQVGTLFANIEDIYEFSSELLEDLEGCSSAGGIAECFVQRSED 182

  Fly  3110 FLCYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNE 3174
            |..|:.||..||.:|..|.... |....|:....|::|....|||.:.||.|||||.:|.|.|.|
Mouse   183 FDIYTLYCMNYPSSLALLRELS-VSPPATLWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQE 246

  Fly  3175 IIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRH 3239
                 |.|...||.|:.|                       ::.|..|:.:|..:...:|:.||.
Mouse   247 -----LGKHWAEGPDSGG-----------------------REMVEEAIVSMTAVAWYINDMKRK 283

  Fly  3240 SETIAR---HQASFQNFKGPPLHLHSARFFLQVDATRQ-----KQNLWNSSYTLFLFDNQLVYCK 3296
            .|..||   .|.....:.||.|   ||...|.::.|.:     ...|......||||...|:..|
Mouse   284 QEHAARLQEVQRRLGGWTGPEL---SAFGELVLEGTFRGGGGGGPRLRGGERLLFLFSRMLLVAK 345

  Fly  3297 RDIIKRSHFIYKGRIFLDRCRVVNV----RDG---KMFGHTIKNSLRIYSESRDKWYDFSFRSAN 3354
            |   :...:.|||.||   |..::|    ||.   |:...||.....:            |::.|
Mouse   346 R---RGPEYTYKGHIF---CCNLSVSETPRDPLGFKVSDLTIPKHRHL------------FQAKN 392

  Fly  3355 RKHRFLSTLALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESS--L 3417
            ::.:.|....|:|.|                :|..|.....:    |:...|...:.....|  :
Mouse   393 QEEKRLWIHCLQRLF----------------FENHPASIPAK----AKQVLLENSLHCAPKSKHI 437

  Fly  3418 PESPAKSTSRLCETLPKKSQSRDGISSAENSQIVTTTSTGS-LGRRHFGNWFRKPKSANCTPSQS 3481
            ||.|   ||.|....|:.:   .|.:....:...:...:|| .|||..|.:   |.......||.
Mouse   438 PEPP---TSPLDSPRPRDA---PGFTPGRRNPAPSPRLSGSRRGRRQSGEY---PPLEGDPGSQW 493

  Fly  3482 PTHKPSF 3488
            |....||
Mouse   494 PGLLTSF 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620	2/4 (50%)
		RhoGEF	3031..3235	CDD:279015	59/204 (29%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	37/147 (25%)
		PH	<3285..3363	CDD:278594	22/84 (26%)
Plekhg2	XP_006539499.1	RhoGEF	103..278	CDD:366202	59/203 (29%)
		PH_PLEKHG1_G2_G3	260..410	CDD:270063	43/186 (23%)
		PTZ00449	<351..742	CDD:185628	43/194 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940