DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and prex2

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:XP_031759716.1 Gene:prex2 / 100490424 XenbaseID:XB-GENE-6048678 Length:1603 Species:Xenopus tropicalis


Alignment Length:377 Identity:97/377 - (25%)
Similarity:174/377 - (46%) Gaps:73/377 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  3027 IRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDI-----FSPNSIRLIFSNITAIYKFQRKF 3086
            :|...:.|||.||.:||..|..:...:...|.:...:     .:..:::::||||..|....::|
 Frog    20 LRVCVLSELLKTERDYVGTLEFLVSAFFHRMMQYAALKADKNVTEETVKILFSNIEDILAVHKEF 84

  Fly  3087 LEALRRGI--EQN---QVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCR-- 3144
            |..:...:  |.|   :|...||:..:.|..|..||:.:.:|...|...::::..||.|.||.  
 Frog    85 LSLIEDCLYPEPNALQEVGNCFLRFKERFAIYDEYCSNHEKAQKLLLEINKIRTVRTFLLNCMLL 149

  Fly  3145 ESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTE 3209
            ..:...::||..:|:||:||||:|||.|.|::|                ::..|.:||    |..
 Frog   150 GGRKNTDVPLEGYLVAPIQRICKYPLLLRELLK----------------RTPKKHSDY----VCV 194

  Fly  3210 LDIPDSQDTVNLALEAMRGITEAVNEGKRHS---ETIARHQASFQNFKGPPLH-------LHSAR 3264
            :|          ||:||:.:...:||.||..   |.:...|:..:.::|..:.       :|.. 
 Frog   195 VD----------ALQAMKAVCTNINEAKRQMEKLEVLEEWQSHIEGWEGSSITDTCTEMLMHGV- 248

  Fly  3265 FFLQVDATRQKQNLWNSSYTLFLFDNQLVYCKRD--IIKRS-------HFIYKGRIFLDRCRVVN 3320
             .|::.:...:..::      |||||.||||||.  .:|.:       .:|::|||..:...|.|
 Frog   249 -LLKISSGNIQDRVF------FLFDNLLVYCKRKQRRLKNNKASTDGHRYIFRGRINTEVMEVEN 306

  Fly  3321 VRDG----KMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQ 3368
            |.||    ...|:|:.|..:|::.:::||:....::...|..:|..:..||:
 Frog   307 VDDGTADFHSSGNTVVNGWKIHNTAKNKWFVCMAKTPEDKQEWLEAILKERE 358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620
RhoGEF 3031..3235 CDD:279015 56/215 (26%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 36/152 (24%)
PH <3285..3363 CDD:278594 29/90 (32%)
prex2XP_031759716.1 RhoGEF 24..209 CDD:395496 56/214 (26%)
PH_Collybistin_ASEF 215..362 CDD:269931 36/152 (24%)
DEP 379..459 CDD:413322
DEP_2_P-Rex 471..563 CDD:239887
PDZ 672..740 CDD:214570
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm48133
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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