DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF3 and arhgef4

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:XP_004917856.1 Gene:arhgef4 / 100487089 XenbaseID:XB-GENE-960463 Length:1808 Species:Xenopus tropicalis


Alignment Length:2213 Identity:470/2213 - (21%)
Similarity:765/2213 - (34%) Gaps:674/2213 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1311 KTGNTDSETPAVAHSDPTSDVPACGTAENPTHLRALTRQDYACIDSSE----AQSDDSHLTRDSI 1371
            :|.:..|:.|:...|:....:....:..:..:...:.|.|...::..|    ..:||:.|:.:.:
 Frog    53 ETRSNFSDCPSELKSEVFESISDAESVASEANGELIRRSDCLFLEKEEPLYSLNNDDNCLSSNIV 117

  Fly  1372 TRESQNDELSSSTLEKLDVSTLPLPALPKRRRTRSRTSPSKHRQQQQQQQQQQQQRHEVIEDANA 1436
              ||.::|.|.:.           ||     .|.|.::...|.....|:..      ::|.| |.
 Frog   118 --ESSHEECSKNA-----------PA-----ETASESNVLHHALTYDQEHL------DIIND-NE 157

  Fly  1437 VDASTAAAGQQHPKPRQGAASPESQKPEISGAKNNAAGEQQKQPQSQQQQTHLSAFQQYVAKRRE 1501
            |   |.......|..:|...|  |...:|||:::|             :.:|...||     .:.
 Frog   158 V---TQLTDLFSPDSKQIGVS--SNIIDISGSESN-------------RSSHKDVFQ-----CQA 199

  Fly  1502 SLEASNRCFNEKLEARRMHYHMGGSAANG------NATASHLTAG----SNGVPTYLFGENFYGV 1556
            .|:.:....:.||.         |..||.      |.|.|..:.|    |..:|...|..:.|. 
 Frog   200 GLQLTGTLISAKLH---------GEIANSKSENCLNCTESERSIGTGVSSQSLPNISFDISHYS- 254

  Fly  1557 PATGRKSISP--TTKKEEIFLNKSGWVQVNTTRGVNKDDNGGGYRSLSYAQQNGGGRVAAMLTDP 1619
            ..:.:..|:.  |...::..|..|...::|....:|           |.:|..|           
 Frog   255 DVSSKHGIASALTQSSQQTCLKTSSLEEINLDCYLN-----------SVSQDVG----------- 297

  Fly  1620 GRRSDLARKSFILQHQQQHQSNISMTEPKFVGSKVEELIQRNEARLSG--CSIRYPSLRPGHRII 1682
                       :|.|.:. :.:||           ::::...::.||.  |...:.....||...
 Frog   298 -----------LLIHTET-EKHIS-----------KDIVHLQDSYLSSQLCEEEHLLSPAGHNEF 339

  Fly  1683 DPQLANILNER---PGFLPVKGPTDLDSPLTPILSPPPAFQDNSRSARRQERRNPGRQQGPLPLP 1744
            ...|..:.::|   .|.:|.....:....:..|||  .:|||..:....::|.:           
 Frog   340 QSTLCVLADDRKETKGCMPEMDMKNSKEKVGGILS--DSFQDIFKGYWEEDRHS----------- 391

  Fly  1745 VPFRSEPQMDPQNPINGSAKGMVFSRSFEYDTRRHTPTDNYVETFSRSFD--GNLSDRLLNLAVL 1807
               ||....:.||...||.|.....|  :..:|:...:..:.|.|....|  .:|.||...:.:.
 Frog   392 ---RSSESEEKQNMTLGSIKNSSLLR--KQVSRQEPMSTGHFEDFQAIGDSSSSLQDRSPVIVLS 451

  Fly  1808 AGQRERSPNFSTLTGNSPNYLTKRESGGGS--------SGSLRSRDSSPKYLHPQATTAYLNAAV 1864
            |.|......:..:..|:    .|.|:|..|        |||..|.:....|     ...|....|
 Frog   452 AHQPRTQTAWKEIEQNT----YKHENGHSSHSNSDENLSGSRESLNQDLVY-----KARYSMGCV 507

  Fly  1865 KEAPPVYSVPTGSQA-KYSPRSRFERTTE----RSKTHALGRS------RKSQFSRVGSAGPLIA 1918
            ::.....:.||.... :.:|  .|::.:|    :..|.|.||.      .|.|.           
 Frog   508 EQEEDEQNGPTFVDINRETP--LFQKDSETIFVQEHTEAHGRHLWDILLDKEQH----------- 559

  Fly  1919 HPNTANVGVSRFRSFDTSKSQRLNSCDSGARSDLSNDELDNEDGGLNDFLSAGSHKFPKIGTSSV 1983
            :|:..::..::.:|......:..|...:|   ::.:..||:.|                      
 Frog   560 NPSQISIQTAKIKSLKQKSYKDPNYHSNG---NMEDSNLDHGD---------------------- 599

  Fly  1984 SVSPFKMQRQRSLTPDRNDSHSSTSSLRKQRSNTPESRS---LTPEERRKKGSQLSLGGARQSSS 2045
              |.|..||:....|..:|...|...:    |::.|:|:   .|.||.|.       |....|:.
 Frog   600 --SVFSAQRRYLTAPQDSDGDESDFEV----SSSEENRNHCLATVEESRD-------GMCYYSTI 651

  Fly  2046 SRSNTFEGRQRHDDKTPPNISRSSSSSSYSGGESHEPLNGTGSTTVTPSAGSGSTSHRRALTAKQ 2110
            .:.:|.       |....|.|..|||:| .|.|.:...|............|...:......:|.
 Frog   652 KKIDTI-------DTVDDNESNCSSSNS-EGTEGNMGYNWKSEINKIEDIKSDVKASESQKDSKI 708

  Fly  2111 AEQEHRIRRSRSLQLTERSPNRAHKSIVNVGALVPQQRSVGVPYQQSRVPGGG--VFPPTIRTSP 2173
            ||    ::.||: ::.|...|:..:..:....:..:..||..|     ||.|.  ...||..||.
 Frog   709 AE----LKDSRT-EIKEEPNNKIKRMNIKNSDIFKKYLSVKTP-----VPNGSQLAAKPTGETSD 763

  Fly  2174 AGAKIHVNSPAPPNSSVRVRHNETDKARSFDFDYNNFSRGGGAKGSSRTAHTSGSGGDSGSNQNL 2238
                                .::.|...| .|.||.         |.|.|  ||||         
 Frog   764 --------------------FSDEDSYES-SFLYNR---------SMRKA--SGSG--------- 787

  Fly  2239 RVERESRSFDDEICEAVLNNNN--GSNGSVSGLRFLQPATDSGQV-SMASTSSSRLRKSNSPVSA 2300
            |::.:  :|....|....:|.|  ..||...|  |.:|.|::.:. |..:|.|.||::..     
 Frog   788 RIDLD--NFTRLRCGVAPSNTNDKSDNGQSQG--FSKPPTENCETKSERNTESKRLKERL----- 843

  Fly  2301 SGMEASRSPQSSGSSTNNLHQQARQS--GSPQSYGTRLCDHELTYEMLRKSPIMNFRRGDSGDYE 2363
              |.|.:|..|.....||....|.||  |:|:....:....:.:::.||     |.:..|...::
 Frog   844 --MWAHKSFSSMFDFKNNDKDSAAQSSEGTPREEKKKSRPLQSSWKTLR-----NSKNKDKDSFK 901

  Fly  2364 -LPVMLRNRETINSG---GNSELNFMSNETRIYEHPTTVLKSQRSLRQSPGSRDDLNLEVAVGVG 2424
             |.|:..:...||:.   |.|:.|  .|     ||...:|                         
 Frog   902 RLSVLNLSAHIINTNMPRGASKEN--GN-----EHLPPIL------------------------- 934

  Fly  2425 GDYIYRQPANQPRSSSVKAEFLTTATTKSCTKTLDTCDYWPRCAACQHKSVSGELKKGPSASGKP 2489
                  .|..||.|..:|....|...|:|        |..|..|...||..|  |:...|..   
 Frog   935 ------DPIKQPSSMEIKPCMTTDTNTES--------DLEPLEAKENHKKWS--LENDDSLQ--- 980

  Fly  2490 LTVLD----------------NVQPHVTSVI----VNEDNAVPGPQLRSLEKSNPSWTFLCSGIA 2534
             |..|                |.||.:|::.    .:|.|.:|                      
 Frog   981 -TTCDDSAFFSQFDSNESHSLNKQPSITTLFNPFSNSEINPMP---------------------- 1022

  Fly  2535 SICQPVQQTETDHSTAQEAAEEDIVIRKVKPNKSRRTGRSRSLPSVMLRRLYLAGMPKPGSNEMG 2599
              |:|:..                     ||.....:.:.|.|.:   .|:....|....::  .
 Frog  1023 --CRPMSP---------------------KPFSQWPSFQRRGLHN---SRISATSMTSLANS--S 1059

  Fly  2600 TTSDCAASLSQQIKAVSSPTLSEPCLEEQPQKGTESTDVANTGSSAGSGGLGVLQKFKRTLNNFN 2664
            |...|..|....:|............::.....::|....||.||.    :.:|:.        .
 Frog  1060 TVDGCPDSPETAVKTWGGYLTDRSSQKDDSSASSQSKPSLNTASSV----MDILRD--------E 1112

  Fly  2665 NKNQLHISPLSPAAVGNNAPKTKTSPTTTTASIAPMITTTT--------ASDPGSEAGDTSSGKY 2721
            :..||..|.:.......||...|..||..|||....|.|.:        ||.......:.:..|.
 Frog  1113 DSRQLVPSSILKMQRERNALLYKKRPTDLTASQYLPINTESRTLTLPQMASMGHKRDSEPTRPKA 1177

  Fly  2722 RFGPL------IWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQYSRATMAVSRQDEPRAFAL 2780
            .|..|      ::..::||:..|        |.|:|   :|.:::  |:|:|:||          
 Frog  1178 LFKSLSCDNLWVYERNQERKLDK--------SIDAG---DLMRNQ--SKASMSVS---------- 1219

  Fly  2781 TNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNIGESDKAERKAPESLPTRSLSQPN 2845
                                      :||                .:..|..|..:.:.|.|.|:
 Frog  1220 --------------------------IGP----------------PEIFRSFPMKVHSFSRSTPS 1242

  Fly  2846 GLESYG--------------MGRPDLED---SDSD-----------------SVASNEEAISFYP 2876
            .|:..|              ..||.|.|   ||.|                 .:|.| |.||...
 Frog  1243 RLDLVGCVRRTSLSVFNDGSTNRPSLFDDLGSDEDFYEELHVSGHRFVGGGEQLAIN-ELISDGS 1306

  Fly  2877 TTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPELGWFPKEFV 2941
            ..|||.|::......:|||.:.|.:||::......||:|||...|            ||||..||
 Frog  1307 VVYAEALWDHVTMDDEELGFKAGSVIEVMDATNKEWWWGRILDSE------------GWFPASFV 1359

  Fly  2942 RIIHCPETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIES 3006
            |:             |...||...:.||...::                  ..|..||       
 Frog  1360 RL-------------RVNQDEPMEDCATKAGDK------------------EQDSRNV------- 1386

  Fly  3007 PPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRL 3071
                  |..:...| ::...:|.:.:.|:|:||.:|:|.|..||:||:....||.|:|:.:.:..
 Frog  1387 ------PRRNGFGQ-NNKDQMRTNVINEILNTEKHYIKHLKDICEGYIKQCRKRDDMFTEDQLWT 1444

  Fly  3072 IFSNITAIYKFQRKFLEALRRGIEQ-----NQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYD 3131
            ||.||..|||||:|||:.|.:.|.:     :::...||:....|..||.|||.:|.|..||....
 Frog  1445 IFGNIEEIYKFQKKFLKTLEKRINKDSPHLSEIGSCFLEYQTDFQIYSEYCNNHPNACTELSKLT 1509

  Fly  3132 RVKDARTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSA 3196
            :||......|.||..|.:.::.|...||.|||:||:|||.|.|::                    
 Frog  1510 KVKKYVHFFETCRLLQKMIDISLDGFLLTPVQKICKYPLQLAELL-------------------- 1554

  Fly  3197 GKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSET---IARHQASFQNFKGPPL 3258
             |.|:.:..|.|         .|..||:||:.:...:||.||..|.   ||..|:|.::::|..:
 Frog  1555 -KYTNSQHRDYT---------NVEAALDAMKNVARLINERKRRLENIDKIAHWQSSIEDWEGEDI 1609

  Fly  3259 HLHSARFFLQVDAT-------RQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRC 3316
            ...|:......:.|       :.:|.::      ||||:|:|:||:|:::|....|||:|.:|..
 Frog  1610 LARSSELIHSGELTKISHLQPKGQQRIF------FLFDHQIVFCKKDLLRRDILYYKGKIDMDDM 1668

  Fly  3317 RVVNVRDG--KMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSEM 3379
            .|:||.||  |.|..|:||:.::..:..::.:.|..:....|.|:|.....||    |.:.:.:.
 Frog  1669 EVLNVEDGKDKDFNITVKNAFKLQGKVSEEIHLFLAKKPEHKQRWLQAFEEER----KQVLLDKE 1729

  Fly  3380 TGF 3382
            |||
 Frog  1730 TGF 1732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620 21/65 (32%)
RhoGEF 3031..3235 CDD:279015 69/208 (33%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 40/144 (28%)
PH <3285..3363 CDD:278594 29/79 (37%)
arhgef4XP_004917856.1 SH3_ASEF 1291..1363 CDD:212906 28/97 (29%)
RhoGEF 1404..1583 CDD:279015 69/208 (33%)
PH_Collybistin_ASEF 1588..1727 CDD:269931 41/148 (28%)
PH 1616..1719 CDD:278594 31/108 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 122 1.000 Domainoid score I5575
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001415
OrthoInspector 1 1.000 - - otm48133
Panther 1 1.100 - - O PTHR45834
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1124
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.010

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