DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and spata13

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:XP_031753117.1 Gene:spata13 / 100485539 XenbaseID:XB-GENE-991808 Length:1254 Species:Xenopus tropicalis


Alignment Length:1564 Identity:363/1564 - (23%)
Similarity:555/1564 - (35%) Gaps:497/1564 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1924 NVGVSRFRSFDTSKSQRL-NSCDSGARSDLSNDEL--DNEDGGLNDFLSAGSHKFPKIGTSSVSV 1985
            |..::..::.|...::.| :....|..|..:|::|  ||::          |.|.....|:|...
 Frog    14 NGTIANSQAIDNGDTRTLADGTGHGGESSTNNEDLHDDNQN----------SSKLVYFFTTSKQR 68

  Fly  1986 SPFKMQRQRSLTPDRNDS-HSSTSSLRKQRSNTPESRSLTPEERRKKGSQLSLGGARQSSSSRSN 2049
            :....:|.||:....|.| .::.|||||..|           .::.|.|.|....|:::    :|
 Frog    69 TNLNNERPRSMMAVGNSSTWNALSSLRKMGS-----------FKKLKSSVLQGIQAKEN----AN 118

  Fly  2050 TFEGRQRHDDKTPPNISRSSSSSSYSGGES-HEPLNGTGS-TTVTPSAGSGSTSHRRALTAKQAE 2112
            .....:....|..|  ||...|.|...|.: .:.|...|| ...|.:|...||            
 Frog   119 IISDNETDVQKCKP--SRMPLSKSMQDGYNLADGLQSDGSDAEETDNAFLRST------------ 169

  Fly  2113 QEHRIRRSRSLQLTERSPNRAHKSIVNVGALVPQQRSVGVPYQQSRVPGGGVFPPTIRTSPAGAK 2177
                 .||||::                                 |..|.|    .|..|.....
 Frog   170 -----HRSRSIR---------------------------------RAYGSG----RINLSDTDKA 192

  Fly  2178 IHVNSPAPPNSSVRVRHNETD------------KARSFDFDYNNFSRGGGAKGSSRTAHTSGSGG 2230
            ....||..|.|.||..|:..:            ..||...|..||.:    |.|.:...||    
 Frog   193 SSSQSPLRPLSPVRQEHSNCEIIVKDLKGSQVIYRRSKSTDNLNFLK----KSSFKRKSTS---- 249

  Fly  2231 DSGSNQNLRVERESRSFDDEICEAVLNNNNGSNGSVSGLRFLQPATDSGQVSMASTSSSRLRKSN 2295
                  || .:.:|.|..:.:.:|.|:.               |.:|    .|.:|...|.::..
 Frog   250 ------NL-TDIKSNSEKEIVQKAPLST---------------PDSD----RMDTTPERRSKRWR 288

  Fly  2296 SPVSASGM-----------------EASR----SPQSSGSSTNN--LHQQARQSGSPQSYGTRLC 2337
            ||:.|...                 |.||    :|:.|..|..|  ||         ..|..|:.
 Frog   289 SPIRAKDFDRVLKIMSNVTDGHWKREGSRCTSPAPEESHRSRPNSRLH---------DDYSRRVS 344

  Fly  2338 DHELTYEMLRKSPIMNFRRGDSGDYELP-VMLRNRETINSGGNSELNFMSNETRIYEHPTTVLKS 2401
            ....|..  |||.|       |....:| |:.|...|     :|.:::..:||::        ||
 Frog   345 SSADTER--RKSAI-------SAPSPVPLVVCRLSYT-----DSNMDYPDSETQV--------KS 387

  Fly  2402 QRSLRQSPGSRDDLNLEVAVGVGGDYIYRQPANQPRSSSVKAEFLTTATTKSCTKTLDTCDYWPR 2466
            ..| ||..||                :..:|:|:             :.|.|....||...::  
 Frog   388 AES-RQCSGS----------------LCTEPSNK-------------SDTSSSLNQLDNEVFY-- 420

  Fly  2467 CAACQHKSVSGELKK--GPSASGKPLTVLDNVQPHVTSVIVNEDNAVPGPQLRSLEKSNPSWTFL 2529
                    ..||..|  .|||:|.|      |:|           ..|.||       :||....
 Frog   421 --------ADGEEPKPHTPSATGTP------VRP-----------TAPKPQ-------SPSMELY 453

  Fly  2530 CSGIASICQPVQQTETDHST-AQEAAEEDIVIRKVKPNKSRRTGRSRSLPSVMLRRLYLAGMPKP 2593
            .|.|:..||       :||| :..:.|.|   .:.:|...:   ..||.||       .....||
 Frog   454 KSAISIHCQ-------NHSTLSLSSMESD---ERTEPTAPK---VERSPPS-------FKDSTKP 498

  Fly  2594 -----GSNEMGTTSDCAASLS-----QQIKAVSSPTLSEPCLEEQPQKGTESTDVANTGSSAGSG 2648
                 |:.:.|.:|....||:     :|.:.|:    .||..:..||...:..|.....|     
 Frog   499 SYYDDGNEDSGISSHSQLSLNAVSEEKQEEVVN----EEPVKKPPPQDDEKKADPQKVAS----- 554

  Fly  2649 GLGVLQKFKRTLNNFNNKNQLHISPLSPAAVGNNAPKTKTSPTTTTASIAPMITTTTASDPGSEA 2713
                     |..|:...:::..  |||.  .|.:|.::.:.|..:.|               :|:
 Frog   555 ---------RKWNSAKCRSRQR--PLSD--YGQSAIRSFSIPEDSVA---------------AES 591

  Fly  2714 GDTSSGKYRFGPLIWRSSKERR----KTKYNRRDKCNSGDSGIQI--ELEQDEQYSRATMAVSRQ 2772
            .:|..||.||..   :|..:.|    |.:.|.|.:..|...|:..  ..|.:|..:.....|.|.
 Frog   592 QETDDGKCRFPS---QSEPQTREHVPKYQLNCRRRPISVIGGVNFFATSEDEEMGAMLQQPVPRP 653

  Fly  2773 DEP--------------RAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNIG 2823
            ..|              |.|||:. |..:.|.:   :.|....:||                ||.
 Frog   654 PIPAHKVPPYKAVSARLRPFALSQ-STPIGLDR---VGRQQQLRAS----------------NIS 698

  Fly  2824 ESDKAERKAPESLPTRSLSQPNGLE---SYG---MGRPDLEDSDSDSVASNEEAISFYPTTYAEV 2882
            ....||..|        |...||.|   ||.   .|.|.......:.:|.| |.||.....|||.
 Frog   699 ADGGAEASA--------LVDDNGSEEDYSYEELCQGNPRYLQPGGEQLAIN-ELISDGSVVYAEA 754

  Fly  2883 LYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPELGWFPKEFVRIIHCP 2947
            |::......|||..:.|.:|.:|......||:|||:..|            .|||..|||:    
 Frog   755 LWDHVTMDDQELAFKAGEVIRVLEASNKDWWWGRIRDRE------------AWFPASFVRL---- 803

  Fly  2948 ETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAF-AEDTDVTVTTDQSNVTLIVIESPPTPS 3011
                                   |..:..|.....:| .||.|:||:..:..            :
 Frog   804 -----------------------RVNQEDVSENSCSFHEEDHDMTVSKSRHK------------N 833

  Fly  3012 APSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNI 3076
            |.::|         .:|.:.|||::|||..|:|.|..||:||:....|...:|:...:..||.||
 Frog   834 AENMD---------QMRANVVREIMDTERVYIKHLKDICEGYIKQCRKHTGMFTEGQLNTIFGNI 889

  Fly  3077 TAIYKFQRKFLEALRRGIEQ-----NQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDA 3136
            ..|||||:|||:.|.:...:     :::...||.....|..||.|||.:|.|.:||....:....
 Frog   890 EDIYKFQKKFLKDLEKKHNKDEPHLSEIGDCFLNNQDDFSIYSEYCNNHPNACLELSNLIKQGKY 954

  Fly  3137 RTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTD 3201
            |...|.||..|.:.::.:...||.|||:||:|||.|.|::|...:                :.:|
 Frog   955 RHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQ----------------EHSD 1003

  Fly  3202 YEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSET---IARHQASFQNFKGPPL----- 3258
            |.:              :..|.|||:.:...:||.||..|:   |||.|.|...::|..:     
 Frog  1004 YSK--------------IKEAYEAMKNVACLINERKRRLESIDKIARWQVSIVGWEGQDILARSS 1054

  Fly  3259 -HLHSARFFLQVDATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVVNVR 3322
             .:||....:.:...:.:|.      |.||||:|||:||:|:::|....|||||.:|.....:|.
 Frog  1055 ELIHSGELTMIIKQGKSQQR------TFFLFDHQLVFCKKDLLRRDILYYKGRIDMDEMEFADVE 1113

  Fly  3323 DGK--MFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSEMTGFEYN 3385
            |||  .|...|||:.::.:...|:...|..:....|.|::.....||    |.:...:..|.|.:
 Frog  1114 DGKDRDFNLNIKNAFKVMNRLTDEVNLFCAKKQEDKQRWIQAFLDER----KRVQDDKDMGMEIS 1174

  Fly  3386 YEER 3389
            .:::
 Frog  1175 EDQK 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620 20/65 (31%)
RhoGEF 3031..3235 CDD:279015 64/208 (31%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 42/143 (29%)
PH <3285..3363 CDD:278594 29/79 (37%)
spata13XP_031753117.1 PTZ00449 <422..717 CDD:185628 89/406 (22%)
SH3_ASEF 734..805 CDD:212906 27/110 (25%)
RhoGEF 844..1023 CDD:214619 64/208 (31%)
PH_Collybistin_ASEF 1028..1166 CDD:269931 43/147 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 122 1.000 Domainoid score I5575
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001415
OrthoInspector 1 1.000 - - otm48133
Panther 1 1.100 - - LDO PTHR45834
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1124
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.100

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