DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF3 and arhgef38

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	XP_009289887.1	Gene:	arhgef38 / 100317614	ZFINID:	ZDB-GENE-090313-83	Length:	762	Species:	Danio rerio

Alignment Length:	310	Identity:	69/310 - (22%)
Similarity:	120/310 - (38%)	Gaps:	72/310 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  2989 DVTVTT----DQSNVTLIVIESPPTPSAPSVDFVAQP-------DHSTIIRRS-AVRELLDTEVN 3041
            |:::.|    .||:.|....:.....|...:..:|.|       .|..:|:|| .:.||:.||.:
Zfish    53 DISIATLVRRSQSDKTEYSSKLKEKMSPHGLSLLASPAMDPEEIRHRKMIKRSKVIEELVRTEGD 117

  Fly  3042 YVK-LLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGI-----EQNQVA 3100
            |.: |...|.:..||....::     ..:..:|:||.::.......|..|:..|     |...:.
Zfish   118 YQRDLELCINEVLLPLREAQV-----VDVDRLFTNIESVCDVSNDLLLRLQDAIADPDPETQLIG 177

  Fly  3101 KVFLKMHKGFL--CYSTYCNAYPRALIELETYDRVKDARTILENC----------RESQNLAELP 3153
            :||::. |..:  .|..||..:..|...|::|:..:|.:.....|          ....||  |.
Zfish   178 EVFIQT-KAVIEEVYKIYCYHHDEANASLKSYEAQEDIQQQFRRCISALKKIYDLEGKPNL--LD 239

  Fly  3154 LSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDT 3218
            :.:.|:.|||||.:|||.|.|:                             .:.|..|.||.: .
Zfish   240 MGSLLIKPVQRIMKYPLLLAEL-----------------------------WNATPTDHPDHR-P 274

  Fly  3219 VNLALEAMRGITEAVNEGKRHSETIARHQASFQNF----KGPPLHLHSAR 3264
            :..||..::.|...:||.||..:.:.:::.|....    |....::||.|
Zfish   275 LQEALTTVKIINININEFKRRKDIVLKYKRSDDETSLMGKLNKFNIHSIR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	48/221 (22%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	5/29 (17%)
		PH	<3285..3363	CDD:278594
arhgef38	XP_009289887.1	RhoGEF	107..291	CDD:279015	48/221 (22%)
		BAR_DNMBP	343..524	CDD:153273
		SH3	591..646	CDD:302595
		SH3_DNMBP_C2	703..758	CDD:213017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810