DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and dnmbp

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:XP_001921555.3 Gene:dnmbp / 100005174 ZFINID:ZDB-GENE-101026-2 Length:1673 Species:Danio rerio


Alignment Length:1307 Identity:259/1307 - (19%)
Similarity:441/1307 - (33%) Gaps:419/1307 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  2257 NNNNGSNG--SVSGLRFLQPATDSGQVSMASTSSSRLRKSNSPVSASGMEASRSPQSSGSSTNNL 2319
            :|..||.|  .||.::.|:.   ||:....|..|:.::.|..|..|.|         ...:..||
Zfish   107 HNAWGSRGLFPVSCIKELEL---SGRSRQLSERSAAVQASELPPHALG---------QARALMNL 159

  Fly  2320 HQQARQSGSPQSYGTRLCDHELTYEMLRKSPIMNFRRGD-------------SGDYELPVMLRNR 2371
            |.|              .|.||           :||.||             .|:      |.||
Zfish   160 HAQ--------------LDEEL-----------DFREGDVITIIGLPEPGWFQGE------LDNR 193

  Fly  2372 ETINSGGNSELNFMSNETRIYEHPTTV-----LKSQRSLRQSPGSRDDLNLEVAV---------- 2421
            ..:...|..||............|.|:     ..::...|::...:|:...|:.:          
Zfish   194 TGLFPEGFVELLGPLRSPLEEPEPQTLEQYPDYSNEDEERRAEEEKDEEPPEMEIQQCQEDEEEE 258

  Fly  2422 --GVGGDYIYRQPANQPRSSSVKAEFLTTATTKSCTKTLDTCDYW------PRCAACQHK--SVS 2476
              .:.|..:|...|.:|.    :.:| ..........::|  |.|      .|.....|:  .:.
Zfish   259 EGAIYGIALYEFRALEPG----ELDF-DVGDRIRILASMD--DGWLEGQIHSRRGVFPHRFVKIE 316

  Fly  2477 GELKKGPSASGKPLTVLDNVQ----------PHVTSVIVNEDNAVP--GPQLRSLEKSNPSWTFL 2529
            |:|:..|...    |:::.:.          |..||  ..||:.||  |.:| |:::.:..|.. 
Zfish   317 GQLQTVPQTE----TLINEISVPKREEECYTPDYTS--AEEDHTVPEYGQEL-SIQQDHTVWDL- 373

  Fly  2530 CSGIASICQPVQQTETDHSTAQEAAEEDIVIRKVKPNKSRRTGRSRSLPSVMLRRLYLAGMPKPG 2594
              ......:..|:....|:...:.:.::   |::..|:|:...:.|       ||    ..|.|.
Zfish   374 --DYFERREEEQKENNGHNVHSDQSSQE---RRMTQNQSQVQPQER-------RR----DRPPPP 422

  Fly  2595 SNEMGTTSDCAASLSQQIKAVSSPTLSEPCLEEQPQKGTESTDVANTGSSAGSGGLGVLQKFKRT 2659
            ..:....|. :|..|.||...|||.:..|.|..:|.....|....:|||.|              
Zfish   423 QTQPNRGSS-SAHRSVQINRRSSPNMGRPQLPPRPSLHALSNRKYSTGSHA-------------- 472

  Fly  2660 LNNFNNKNQLHISPLSPAAVGNNA-PKTKTSPTTTTASIAPMITTTTASDPGSEAGDTSSGKYRF 2723
                    .|...|.:|..:..:. |..||||.:|..                    .::|||..
Zfish   473 --------SLRQPPPAPITMNQSLNPPNKTSPNSTWT--------------------RNNGKYAS 509

  Fly  2724 ----GPLIWRSSKER-RKTKYNRRDKCNSGD--SGIQIELEQDEQ----------YSRATMAVSR 2771
                .||..:||.|: |:.|..|....|..|  ||...|.:...|          .:..|:|:|.
Zfish   510 YNSRNPLSSKSSGEKNRQKKLTRHASVNDADIISGGSSEQQAWPQVQGSNGFPTSQTMGTLALSA 574

  Fly  2772 QDEPRAFA--LTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNI----GESD---- 2826
            :|.....:  |......:......|..::...:.|..||     .|:::|.:|    .|:|    
Zfish   575 KDLEAKLSQQLIEFEKSLPSHSNEATEQSRWEEVSGRLG-----NKVSRHFSIMDYSDENDIIRG 634

  Fly  2827 ----KAERKAPES------------------------------LPTRS-LSQPNGLESYGMGRPD 2856
                ..||..|.:                              .||.: .||.||..:....||.
Zfish   635 SSHSSIERLLPSTSSPSGSASSSLERRKNLRPPPPRPRVLRPPAPTNTHWSQTNGRITPQPYRPA 699

  Fly  2857 LEDSDSDSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEE 2921
            ...........:..|::  |.|.:...||    .|.|             :|:         .||
Zfish   700 RPAPRPPPPCPHTNAVT--PPTTSNPFYN----SPDE-------------EEI---------VEE 736

  Fly  2922 TNLVEDILGPELGWFPKEFVR-------IIHCPETDNFFIAHRAAADEAAA-----EEATARAEE 2974
            ....||:|..|     ||..|       ::...|.:.....:...|.|..|     ::.|:|.: 
Zfish   737 MEEPEDVLEAE-----KEMEREQEQYRLLLRLEEVEREIDMYSNTAQELQAMLDEEQDETSRQQ- 795

  Fly  2975 GSVPVPVAAFAEDTDVTVTTDQ---SNVTLIV-----IESPPTPSAPSVDFVAQPDHSTIIRRS- 3030
               .:....|...|..|:|.:|   ..:||:.     :||.|..:|.|.|    |:...:.:|: 
Zfish   796 ---ALENLEFCSYTMETLTLEQQQLQEMTLLASQPKSLESSPASAANSED----PELRMLEKRTK 853

  Fly  3031 AVRELLDTEVNYVKLLAAICDGYLPAMSKR----IDIFSPNSIRLIFSNITAIYKFQRKFLEALR 3091
            .:.|||.||.:|:|.|.......:..:.|:    ||...      :|.||:::....|:..:.|:
Zfish   854 VIEELLQTEHDYIKDLQMCVKEIIQPLQKKQVQGIDFDG------LFGNISSVIDLSRRLNKTLQ 912

  Fly  3092 RGIEQNQVAKVFLKMHKGFL--CYSTYCNAYPRALIELETYDRVKDARTILENC--------RES 3146
               :.:.:.:|||. :|..|  .|..||..:..|:..||||::.::.:..:..|        ||.
Zfish   913 ---DTDSIGQVFLS-YKDQLEDVYKIYCQNHDDAISLLETYEKDENIQKHVLECLEKLRGIYREW 973

  Fly  3147 QNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELD 3211
            .....:.|.:.|:.||||:.||||.|.|::.:..|                  :.:::..::|  
Zfish   974 GKTNYINLGSFLIKPVQRVMRYPLLLMELLNTTPE------------------SHHDRQQLSE-- 1018

  Fly  3212 IPDSQDTVNLALEAMRGITEAVNEGKRHSETIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQ 3276
                      |:.:::.|...:||.||..:.:.:::      ||              |..|   
Zfish  1019 ----------AVMSIKEINVNINEYKRRKDLVVKYR------KG--------------DEDR--- 1050

  Fly  3277 NLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVVNVRDGKMFGHTIKNSLRIYSES 3341
                      |.|.........|||:|:                    ::..| :|:...|..:.
Zfish  1051 ----------LIDKISKLSMHSIIKKSN--------------------RVSSH-LKHLTGISPQI 1084

  Fly  3342 RDKWYDFS---FRSANRKHR-FLSTLALERQFGGKALYVSEMTGFEY--NYEERPGDYSDQSDYD 3400
            :|:.:|.:   ||...|..: |:..::|..|...::..|..:....:  .|.||      |...|
Zfish  1085 KDEAFDDAEKRFRLQERLIKSFIRNISLYLQHIRESASVKVLAAISFCDIYTER------QQQMD 1143

  Fly  3401 AQDFELA 3407
            .:.|:.|
Zfish  1144 PERFQRA 1150

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620 15/65 (23%)
RhoGEF 3031..3235 CDD:279015 48/217 (22%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 21/136 (15%)
PH <3285..3363 CDD:278594 15/81 (19%)
dnmbpXP_001921555.3 SH3_DNMBP_N1 6..56 CDD:212728
SH3 70..123 CDD:354299 6/15 (40%)
SH3_DNMBP_N3 152..202 CDD:212730 16/80 (20%)
SH3 263..312 CDD:354299 10/55 (18%)
RhoGEF 854..1031 CDD:306973 48/216 (22%)
BAR_DNMBP 1083..1275 CDD:153273 16/74 (22%)
SH3_DNMBP_C1 1356..1412 CDD:212732
SH3_DNMBP_C2 1613..1669 CDD:213017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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