DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm2 and Timm50

DIOPT Version :9

Sequence 1:	NP_612023.1	Gene:	ttm2 / 38049	FlyBaseID:	FBgn0035124	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	XP_003748854.1	Gene:	Timm50 / 687295	RGDID:	1587684	Length:	353	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	121/307 - (39%)
Similarity:	186/307 - (60%)	Gaps:	8/307 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 PQTSEESNDEESRERRKLEEEEEQKELERAFRRMKLGF---GLFGIGSMLFSFWAIYFYGRPSLD 154
            |:|.|:..:..:|...|.:..:.|...|......|:..   ||.|.|..:.   .:|.:|...:|
  Rat    31 PRTPEQVTEIANRGGSKTQGPQHQPGSEGPSYAKKVALWIAGLLGAGGTVS---IVYIFGNNPVD 92

  Fly   155 EHGNEVIDEFSCLPQMQQLMWRTWKSVNRFQRFFKEPSRKKLLPDPLQPPYVQPPYTLVLEIKDV 219
            |:|.::.|||...|.:.|.:.||:|....:::...||:...||||||:.||.|||||||||:..|
  Rat    93 ENGTKIPDEFDSDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPDPLREPYYQPPYTLVLELTGV 157

  Fly   220 LVHPDWTYETGWRFKKRPGVDVFLKECAKYFEIVVYTAEQGVTVFPLVDALDPNGCIMYRLVRDS 284
            |:||:|:..||||||||||::...::.|..:|||::|:|.|:|.|||:|::||:|.|.|||.||:
  Rat   158 LLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDA 222

  Fly   285 THFDGGHHVKNLDNLNRDLKRVVVVDWDRNSTKFHPSNSFSIPRWSGNDNDTTLFELTSFLSVLG 349
            |.:..|||||::..||||..||||||..:.:.:..|.|..::..|.||.:|..|.:|::||..:.
  Rat   223 TRYMEGHHVKDISCLNRDPARVVVVDCKKEAFRLQPFNGVALRPWDGNSDDRVLLDLSAFLKTIA 287

  Fly   350 TSEIDDVREVLQYYNQFSDSLSQFRENQRKL--GELMHAEEVEKTSK 394
            .::::|||.||::|....|.|..|::.|.:|  .|.....|:.|::|
  Rat   288 LNQVEDVRTVLEHYALEDDPLEAFKQRQSRLEQEEQQRLAELSKSNK 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm2	NP_612023.1	CPDc	208..336	CDD:214729	65/127 (51%)
Timm50	XP_003748854.1	HAD_FCP1-like	147..262	CDD:319823	61/114 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347803
Domainoid	1	1.000	178	1.000	Domainoid score	I3459
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3030
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1142452at2759
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm45022
orthoMCL	1	0.900	-	-		OOG6_102279
Panther	1	1.100	-	-	O	PTHR12210
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2489
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800