DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm2 and timm50

DIOPT Version :9

Sequence 1:	NP_612023.1	Gene:	ttm2 / 38049	FlyBaseID:	FBgn0035124	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001120038.1	Gene:	timm50 / 100145004	XenbaseID:	XB-GENE-963112	Length:	368	Species:	Xenopus tropicalis

Alignment Length:	343	Identity:	132/343 - (38%)
Similarity:	197/343 - (57%)	Gaps:	21/343 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 VGHR---RYSTYEK--------TSTQILTKLFPQTSEESNDEESRERRKLEEEEEQKELERAFRR 125
            :|.|   ||..:..        |...:..||..:.:|.|:|....|.::.:::|.....:|...|
Frog    19 LGQRTELRYRAFSSEQGAEGGLTGAVLQEKLQRRENEASSDSSGSEEKQKKQKENAANAKRFLLR 83

  Fly   126 MKLGFGLFGIGSMLFSFWAIYFYGRPSLDEHGNEVIDEFSCLPQMQQLMWRTWKSVNRFQRFFKE 190
            .....|:.|.||:      :|.:|..|:||.||::.|||...|.:.|.:.||:|....:::...|
Frog    84 AAGLLGVAGSGSL------VYIFGSNSVDEQGNKIPDEFDSDPPVVQQIRRTYKYFIDYRQMIIE 142

  Fly   191 PSRKKLLPDPLQPPYVQPPYTLVLEIKDVLVHPDWTYETGWRFKKRPGVDVFLKECAKYFEIVVY 255
            |:..|||||||:.||.|||||||||:.|||:||:|:..||||||||.|:|...::.|..:|||::
Frog   143 PTSPKLLPDPLKEPYYQPPYTLVLELTDVLLHPEWSLSTGWRFKKRAGIDNLFQQLAPLYEIVIF 207

  Fly   256 TAEQGVTVFPLVDALDPNGCIMYRLVRDSTHFDGGHHVKNLDNLNRDLKRVVVVDWDRNSTKFHP 320
            |:|.|:|.|||:|.:||:|.:.|||.||:|.:..|||||::..||||...||:||..|.:.|..|
Frog   208 TSETGLTAFPLIDNVDPHGFVSYRLFRDATRYTDGHHVKDISCLNRDPSHVVIVDCKREAFKLQP 272

  Fly   321 SNSFSIPRWSGNDNDTTLFELTSFLSVLGTSEIDDVREVLQYYNQFSDSLSQFRENQRKLGELMH 385
            .|..:|.:|.|:..|..|::||:||..:..|.:.|||.||:.|....|.|..|:..|.:|.:
Frog   273 YNGLAIKKWDGSSEDRALYDLTAFLKTIAVSGVSDVRSVLENYALEEDPLEAFKRRQTQLEQ--- 334

  Fly   386 AEEVEKTSKSRPVVKNWT 403
             ||.::.:....:.|..|
Frog   335 -EEQQRLADMSQLSKRQT 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm2	NP_612023.1	CPDc	208..336	CDD:214729	65/127 (51%)
timm50	NP_001120038.1	LPLAT	<64..>128	CDD:388412	20/69 (29%)
timm50	NP_001120038.1	HAD_FCP1-like	161..278	CDD:319823	61/116 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3648
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3026
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1142452at2759
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm48079
Panther	1	1.100	-	-	O	PTHR12210
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1522
SonicParanoid	1	1.000	-	-		X2489
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190