DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and Tdrd1

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_006527536.1	Gene:	Tdrd1 / 83561	MGIID:	1933218	Length:	1173	Species:	Mus musculus

Alignment Length:	769	Identity:	163/769 - (21%)
Similarity:	263/769 - (34%)	Gaps:	222/769 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 MKTGTDKLRAAERFAKEKRLRQWQD------YQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSN 367
            ::..|.|:.....|.|::.....||      .|...|.|..|..:         ||:..|..|..
Mouse     7 LEASTCKMAEPFNFEKKESKPPPQDPLRSPVAQHNHPTFRLKSPE---------NGNTKNNFLLC 62

  Fly   368 GQVKKVFFS-------SIRPPRDQRAVVGTDGEEIVKAPPRGKNYRPL----------------- 408
            .|.|:...|       |..|......|.|:.|:.  |.||.|....||
Mouse    63 EQNKQYLASQEDSSVVSSNPAVVNGEVGGSKGDR--KPPPTGNPVSPLSLGNSSPPNQVKTKPSS 125

  Fly   409 -------------------YEIPHMFDA------------------------------------R 418
                               ...|.:|::                                    |
Mouse   126 NVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRR 190

  Fly   419 EFLRKKLINKKVQCNLDYISPPRENF--------------PEKYCYTVSIGGQNV---------- 459
            ::.....|.:.||.:|:.:...:..|              |......::.|.:.|
Mouse   191 DWSSHSTICRPVQQSLNKLEDNKSPFETKAIEVKSEQVDCPPGVTKEITAGAERVMFSDLRSLQL 255

  Fly   460 AEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAE-----QQAIKGLKGLHAK---KD-----NATL 511
            .:.|..||..|..::      .|:.|.||.::|     .|....||..:|.   :|     ...:
Mouse   256 KKTMEIKGTVTEFKH------PSNFYIQLYSSEVLENMNQLSTSLKETYANVVPEDGYLPVKGEV 314

  Fly   512 RVNDLTVDHSRIKVQYLPSWQRA-------LRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGIS 569
            .|...|||.         :|.||       |:.:|.|.::..|:  ...:|.||  |..|..|:.
Mouse   315 CVAKYTVDQ---------TWNRAIVQAVDVLQRKAHVLYIDYGN--EEMIPIDS--VHPLSRGLD 366

  Fly   570 C--PRSSRPALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHI--DTTDKAGSSVIGWLWTDSGA 630
            .  |.:.:..::||....|| :.:..:...:..:.::..||.:  ...::..:..:..:...||.
Mouse   367 LFPPSAIKCCVSGVIPTAGE-WSEGCVAAVKALLFEQFCSVKVMDILEEEVLTCAVDLVLQSSGK 430

  Fly   631 NLSVALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKVV 695
            .|...|||.|..                :......:.::::..:.:|:|.:   ||   .|.|:|
Mouse   431 QLDHVLVEMGYG----------------VKPGEQSSTEQSVDHSALEDVGR---VT---VESKIV 473

  Fly   696 AER-----KVNYENV------IVTEITETLTFFAQSVESGSKLESLMSKLHADFQSNPPIAGSYT 749
            .:|     ||...||      :|..|.....||.|.::||.||..|...| :::..:......:.
Mouse   474 TDRNALIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESL-SEYCGHVIPRSDFY 537

  Fly   750 PKRGDLVAAQFTLDNQWYRAKVERVQGSNATVL--YIDYGNKETLPTNRLAALPPAFSSEKPYAT 812
            |..||:..|||:.|:|||||.| ....|..:||  |:||||.|.|...||..:.|........|.
Mouse   538 PTIGDVCCAQFSEDDQWYRASV-LAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQAL 601

  Fly   813 EYALALVALPTDNEDKEEALRAFSEDVLNHKVQLNVELKVTGSPNLATLRDPTT--KVDFGKQLV 875
            ...||.|. |:......||:....|.|.|..|.:.| :.:.|:..|..|.|.:.  .|...|.|:
Mouse   602 NCVLAGVK-PSLGIWTPEAVCVMKEMVQNRMVTVRV-VGMLGTRALVELIDKSVAPHVSASKALI 664

  Fly   876 AEGLVLAEQRGERKLKELVDQYKAAQEAARVAHLAI--------WKYGDITQDD 921
            ..|..:.|       |::.|:..:...|:  ..|||        |.:.:.|.|:
Mouse   665 DSGFAIKE-------KDVADKGSSMHTAS--VPLAIEGPAEALEWTWVEFTVDE 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615
		SNc	195..333	CDD:214615	4/23 (17%)
		SNc	346..504	CDD:320778	41/265 (15%)
		SNc	538..672	CDD:214615	23/137 (17%)
		TUDOR	697..817	CDD:306940	43/132 (33%)
		SNc	767..914	CDD:320778	45/158 (28%)
Tdrd1	XP_006527536.1	zf-MYND	163..199	CDD:366792	1/35 (3%)
		TUDOR	262..378	CDD:366171	31/134 (23%)
		TUDOR	493..606	CDD:366171	38/114 (33%)
		TUDOR	718..825	CDD:366171
		TUDOR	936..1050	CDD:366171
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900