DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and Tudor1

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001154697.2	Gene:	Tudor1 / 830626	AraportID:	AT5G07350	Length:	1007	Species:	Arabidopsis thaliana

Alignment Length:	1034	Identity:	336/1034 - (32%)
Similarity:	525/1034 - (50%)	Gaps:	187/1034 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 APPAPTKSLSGIVKQVLSGDTVVIRA---TKGAPPPEKQITFSHVLAPKLARRPGAGGDETKDEP 78
            |..|..:.|.|.||.|.|||.:||.|   .:..|||||.||||.::|||:|||.|.      |||
plant     2 ATGAENQWLKGRVKAVTSGDCLVITALSHNRAGPPPEKTITFSSLMAPKMARRGGI------DEP 60

  Fly    79 WAWESREFLRKKLIGVEVTFTFD--KPANSNREYGFVWIGKDKETGENVVESIVREGLVSVRREG 141
            :||||:|||||..||.||.|..|  ..|.:.||:|.|::|     .||:.:.:|:.|...||..|
plant    61 FAWESKEFLRKLCIGKEVAFKVDYKVEAIAGREFGSVFLG-----NENLAKLVVKTGWAKVREPG 120

  Fly   142 RPTAEQ-----QTLIELEDQARAAGRGKWSPTASAAD-KVRNIKWSHENPAHLVDIYG------- 193
            :...::     :.|::||:.|:..|.|:||....||: .:||:.     |:.:.|..|
plant   121 QQNQDKVSPYIKELLQLEELAKQEGYGRWSKVPGAAEASIRNLP-----PSAIGDSAGFDAMGLL 180

  Fly   194 ----GNPVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGV-------------------KL 235
                |.|::.|:|.||||||:|.:|||:|.::.:.::|::.|.:                   .:
plant   181 AANKGKPMEGIVEQVRDGSTIRVYLLPEFQFVQVFVAGVQAPSMGRRTTNGSVVETVPDEPNGDV 245

  Fly   236 DADGKPDL------------SVKV---PFADEARYYVETRLLQRDVEIRLESVNN-SNFIGTILY 284
            .|:.:..|            ||:|   |||.||:|:.|.|:|.|||.|.||.|:. :|.||::.|
plant   246 SAESRGPLTTAQRLAASAASSVEVSSDPFATEAKYFTEHRVLSRDVRIVLEGVDKFNNLIGSVHY 310

  Fly   285 PKG----NIAESLLREGLAKCVDWSMAVM-KTGTDKLRAAERFAKEKRLRQWQDYQAKTPAFNSK 344
            ..|    ::...|:..||||.|:||..:| :....||:|||...|:.:::.|.:|  ..||.|||
plant   311 SDGETVKDLGLELVENGLAKFVEWSANMMEEEAKKKLKAAELQCKKDKVKMWANY--VPPATNSK 373

  Fly   345 ---EKDFSGTVVEVFNGDAINVRLSNGQVKKVFFSSIRPPRDQRAVVGTDGEEIVKAPPRGKNYR 406
               :::|:|.||||.:||.:.|     ....|.|.|  |..::|..:.:     :::|..|...|
plant   374 AIHDQNFTGKVVEVVSGDCLIV-----ADDAVPFGS--PAAERRVCLSS-----IRSPKMGNPRR 426

  Fly   407 PLYEIPHMFDAREFLRKKLINKKVQCNLDYI-------SPPRENFPEKYCYTVSI---------- 454
            .....|:..:||||||::||.|:|...::|.       .|......:::....|:
plant   427 EEKPAPYAREAREFLRQRLIGKQVIVQMEYSRKVTQGDGPTTSGAADRFMDFGSVFLPSAAKADS 491

  Fly   455 ------------GGQ----NVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKGLKGLH 503
                        |.|    |:||.::.:|....||:| |.::||:.||.|:|||.:|:.|.||:|
plant   492 DEVTAPPAAAIAGSQPVGVNIAELVLVRGFGNVVRHR-DFEERSNHYDALLAAEARALAGKKGIH 555

  Fly   504 AKKDNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGI 568
            :.|::..:.:.||||..::....:|||.||..|..|:||:|.||.|.::::||.:|.:.|..:|:
plant   556 SAKESPAMHITDLTVSAAKKAKDFLPSLQRIRRIPAVVEYVLSGHRFKLYIPKITCSIAFSFSGV 620

  Fly   569 SCPRSSRPALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSGANLS 633
            .||            ..|||:.:||::..|.|::||||.:.::|.|:.| :.:|.:| :|..|::
plant   621 RCP------------GRGEPYSEEAISVMRRRIMQRDVEIEVETVDRTG-TFLGSMW-ESRTNVA 671

  Fly   634 VALVEEGLAEVH--FSAEKSEYYRQLKIAEDRAKAAKKNIWTNYV--EEVPKEKTVTEEEKEDKV 694
            ..|:|.|||::.  |.|::......|:.||..||..|..||.|||  |||....|.|.|.::.:.
plant   672 TVLLEAGLAKMQTSFGADRIAEAHLLEQAERSAKNQKLKIWENYVEGEEVSNGNTNTVETRQKET 736

  Fly   695 VAERKVNYENVIVTEITETLTFFAQSVESGSKLESLMSKLHADFQSNPPIAGSYTPKRGDLVAAQ 759
            :        .|:|||:.....|:.||. ...|:.|:.::|.:....:.||.||:.|||||:|.||
plant   737 L--------KVVVTEVLGGGRFYVQSA-GDQKIASIQNQLASLSIKDAPIIGSFNPKRGDIVLAQ 792

  Fly   760 FTLDNQWYRAKV-----ERVQGSNA--TVLYIDYGNKETLPTNRLAALPPAFSSEKPYATEYALA 817
            |:|||.|.||.:     ..||..:.  .|.||||||:||:|.:.:..:.|:.|:....|....||
plant   793 FSLDNSWNRAMIVTAPRAAVQSPDEKFEVFYIDYGNQETVPYSAIRPIDPSVSAAPGLAQLCRLA 857

  Fly   818 LVALPTDNED-----------------KEEALRAFSEDVLNHKVQLNVELKVTGSPNLATLRDPT 865
            .:.:|:..:|                 ||........|....|    |:.:.||:..:.||....
plant   858 YIKVPSLEDDFGPEAGEYLHTVTLGSGKEFKAVIEERDTSGGK----VKGQGTGTEFVVTLIAVD 918

  Fly   866 TKVDFGKQLVAEGLVLAEQR---GERKLKELVDQYKAAQEAARVAHLAIWKYGDITQDD 921
            .::.....::.||:...|:|   |.:..:..:|..:..||.||.:.:.||:||||..||
plant   919 DEISVNAAMLQEGIARMEKRQKWGHKGKQAALDALEKFQEEARKSRIGIWQYGDIESDD 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	64/152 (42%)
		SNc	195..333	CDD:214615	58/177 (33%)
		SNc	346..504	CDD:320778	53/190 (28%)
		SNc	538..672	CDD:214615	45/135 (33%)
		TUDOR	697..817	CDD:306940	44/126 (35%)
		SNc	767..914	CDD:320778	42/173 (24%)
Tudor1	NP_001154697.2	SNc	10..150	CDD:214615	64/150 (43%)
		SNc	37..151	CDD:294094	52/124 (42%)
		SNc	186..364	CDD:214615	58/177 (33%)
		SNc	195..364	CDD:294094	55/168 (33%)
		SNc	378..556	CDD:214615	53/190 (28%)
		SNc	387..556	CDD:294094	48/181 (27%)
		SNc	587..712	CDD:214615	46/138 (33%)
		SNc	595..712	CDD:294094	42/130 (32%)
		TUDOR	734..857	CDD:278965	44/131 (34%)
		TUDOR	786..839	CDD:119391	24/52 (46%)
		SNc	860..968	CDD:294094	21/111 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	84	1.000	Domainoid score	I2850
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8665
Inparanoid	1	1.050	457	1.000	Inparanoid score	I374
OMA	1	1.010	-	-		QHG53811
OrthoDB	1	1.010	-	-		D227839at2759
OrthoFinder	1	1.000	-	-		FOG0004476
OrthoInspector	1	1.000	-	-		otm2475
orthoMCL	1	0.900	-	-		OOG6_102097
Panther	1	1.100	-	-	O	PTHR12302
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3762
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840