DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and Snd1

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_073185.2	Gene:	Snd1 / 64635	RGDID:	631340	Length:	909	Species:	Rattus norvegicus

Alignment Length:	944	Identity:	472/944 - (50%)
Similarity:	635/944 - (67%)	Gaps:	58/944 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATAANTATAAGAAKDAPPAPTKSLSGIVKQVLSGDTVVIRA-TKGAPPPEKQITFSHVLAPKLA 64
            ||:|.::.::.|     |..||.. .||||.||||..:::|. .:|.||||:||..|::.|..||
  Rat     1 MASAQSSGSSGG-----PAVPTVQ-RGIVKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLA 59

  Fly    65 RRPGA---GGDETKDEPWAWESREFLRKKLIGVEVTFTFDKPANSNREYGFVWIGKDKETGENVV 126
            ||..|   .|.:|.|||||:.:||||||||||.||.||.:......||||.:::||| ..|||:.
  Rat    60 RRAAATQPDGKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKTPQGREYGMIYLGKD-TNGENIA 123

  Fly   127 ESIVREGLVSVRREG--RPTAEQQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLV 189
            ||:|.|||.| ||||  ....||..|.|.|:||:|:.:|.|| ..:.:..:|::|::.|||.|.|
  Rat   124 ESLVAEGLAS-RREGMRANNPEQNRLSECEEQAKASKKGMWS-EGNGSHTIRDLKYTIENPRHFV 186

  Fly   190 DIYGGNPVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGVKLDADGK--PDLSVKVPFADE 252
            |.:...||.||||||||||.|||.||||.:.:|:|:|||:||..:.:.||.  |:     |||.|
  Rat   187 DSHHQKPVNAIIEHVRDGSVVRALLLPDHYLVTVMLSGIKCPTFRRETDGSETPE-----PFAAE 246

  Fly   253 ARYYVETRLLQRDVEIRLESVNNSNFIGTILYPKGNIAESLLREGLAKCVDWSMAVMKTGTDKLR 317
            |:::.|:|||||||:|.|||.:|.|.:||||:|.|||.|.||:||.|:|||||:||...|.:|||
  Rat   247 AKFFTESRLLQRDVQIILESCHNQNILGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLR 311

  Fly   318 AAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFFSSIRPPR 382
            ||||||||:|||.|:||...|...:.|:|.|...|::|.|.|||.|:|::|..|.:..|||||||
  Rat   312 AAERFAKERRLRIWRDYVPPTANLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPR 376

  Fly   383 DQRAVVGTDGEEIVKAPPRGKNYRPLYEIPHMFDAREFLRKKLINKKVQCNLDYI---SPPRENF 444
                   .:|:.|   ..:.|..||||:||:||:||||||||||.|||...:|||   ||..|..
  Rat   377 -------LEGDNI---QDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVSVTVDYIRPASPATETV 431

  Fly   445 P---EKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKGLKGLHAKK 506
            |   |:.|.||:|||.|:|||:|:|||||.:|||||||||||.||:|:|||.:|||..||||:||
  Rat   432 PAFSERTCATVTIGGINIAEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKK 496

  Fly   507 DNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGISCP 571
            :....||.|::.|..:.| |:||..|||.|:||:||:|.|||||::::||::||:|||||||.||
  Rat   497 EVPIHRVADISGDTQKAK-QFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECP 560

  Fly   572 RSSR--PALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSGANLSV 634
            |.:|  |.|    .||||||.:||..||:|.||||:|.|.:::.|||| :.||||..| ||||||
  Rat   561 RGARNLPGL----VQEGEPFSEEATLFTKELVLQREVEVEVESMDKAG-NFIGWLHMD-GANLSV 619

  Fly   635 ALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKVVAERK 699
            .|||..|::|||:||:|.||:.|..||:.||..|:.:|.:|.|:..:|.....|||      ||.
  Rat   620 LLVEHALSKVHFTAERSAYYKPLLSAEEAAKQRKEKVWAHYEEQPVEEVMPVLEEK------ERS 678

  Fly   700 VNYENVIVTEITETLTFFAQSVESGSKLESLMSKLHADFQSNPPIAGSYTPKRGDLVAAQFTLDN 764
            .:|:.|.|||||:.|.|:.|.||:|::||.||..:.:|..|:||:.|:|.|:||:...|:| :|.
  Rat   679 ASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRSDISSHPPVEGAYAPRRGEFCIAKF-VDG 742

  Fly   765 QWYRAKVERVQG-SNATVLYIDYGNKETLPTNRLAALPPAFSSE--KPYATEYALALVALPTDNE 826
            :||||:||:|:. :...|.||||||:|.||:.||.|||||||:.  ...|||||.|.:.:|.|.:
  Rat   743 EWYRARVEKVESPAKVHVFYIDYGNREILPSTRLGALPPAFSTRVLPAQATEYAFAFIQVPQDED 807

  Fly   827 DKEEALRAFSEDVLNHKVQLNVELKVTGSPNLATLRDPTTKVDFGKQLVAEGLVLAEQRGERKLK 891
            .:.:|:.:...|:.|.:..||||......|:: ||:...:|.|.|..||.||||:.|.|.|::.:
  Rat   808 ARTDAVDSVVRDIQNTQCLLNVEHLSASCPHV-TLQFADSKGDVGLGLVKEGLVMVEVRKEKQFQ 871

  Fly   892 ELVDQYKAAQEAARVAHLAIWKYGDITQDDAPEF 925
            :::.:|..|||:|:.|.|.:|:|||...|||.||
  Rat   872 KVITEYLNAQESAKSARLNLWRYGDFRADDADEF 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	74/148 (50%)
		SNc	195..333	CDD:214615	85/139 (61%)
		SNc	346..504	CDD:320778	90/163 (55%)
		SNc	538..672	CDD:214615	77/135 (57%)
		TUDOR	697..817	CDD:306940	62/122 (51%)
		SNc	767..914	CDD:320778	63/149 (42%)
Snd1	NP_073185.2	SNc	20..165	CDD:214615	76/147 (52%)
		SNc	25..165	CDD:238102	72/142 (51%)
		SNc	192..327	CDD:214615	85/139 (61%)
		SNc	200..327	CDD:238102	79/131 (60%)
		Nuclear localization signal. /evidence=ECO:0000255	320..324		2/3 (67%)
		SNc	340..494	CDD:214615	90/163 (55%)
		SNc	349..495	CDD:238102	88/155 (57%)
		Nuclear localization signal. /evidence=ECO:0000255	387..391		1/3 (33%)
		SNc	524..659	CDD:214615	79/140 (56%)
		SNc	532..659	CDD:238102	74/132 (56%)
		TUDOR	676..798	CDD:278965	62/122 (51%)
		TUDOR	727..783	CDD:197660	30/56 (54%)
		SNc	<843..894	CDD:294094	20/50 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352992
Domainoid	1	1.000	130	1.000	Domainoid score	I5104
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8665
Inparanoid	1	1.050	846	1.000	Inparanoid score	I416
OMA	1	1.010	-	-		QHG53811
OrthoDB	1	1.010	-	-		D211699at33208
OrthoFinder	1	1.000	-	-		FOG0004476
OrthoInspector	1	1.000	-	-		oto98601
orthoMCL	1	0.900	-	-		OOG6_102097
Panther	1	1.100	-	-	LDO	PTHR12302
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3762
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810