DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and tdrd6

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_694024.6	Gene:	tdrd6 / 565665	ZFINID:	ZDB-GENE-041001-210	Length:	2117	Species:	Danio rerio

Alignment Length:	734	Identity:	155/734 - (21%)
Similarity:	266/734 - (36%)	Gaps:	211/734 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 IIEHVRDGSTV---RAFLLP------DFHYITLMISGIRCPGVKLDADGKPDLSVKVP------- 248
            :|..|..|.|:   ::.|||      |.  :::.:..|.|        |..|:..::|
Zfish  1003 VINFVDYGDTLEVDKSDLLPVPIEAGDI--MSVPVQAIEC--------GLSDMPEELPCEVDNWF 1057

  Fly   249 --FADEARYYVETRLLQRDVEIRLESVNNSNFIGTILYPK------GNIAESL----LREGLAKC 301
              |||...:.......:...::.||..:....:..::..|      .|.|.:.    |:...|:.
Zfish  1058 RKFADSHCFTALIVAKEPAGKLILELYDGKTQVNALIKQKFHNEIHKNDASTFKIYGLKSRAAES 1122

  Fly   302 VDWSMAVMKTGTDKLR-AAERFAKEKR---LRQWQDYQAKTP----AFNSKEKDFSGTVVEVFNG 358
            |:.|....::.|...| |.::..|.:.   :::..|..:|.|    .|::     :|......:.
Zfish  1123 VEASACKKESSTGPKRDAIDQVPKSRESHAIQRSNDVASKQPQSRWGFST-----NGRPEPTRDS 1182

  Fly   359 DAIN-------VRLSNGQVKKVFFSSIRPPRDQRAVVGTDGEEIVKAPPRG---KNYRPLYEIPH 413
            ..||       :|.|.|.::....|| :|             |:||..|:.   ::..|:..|..
Zfish  1183 GTINNCQKQPELRTSQGNLRHPCTSS-KP-------------EVVKPKPQALLKESALPIKSIKP 1233

  Fly   414 MFDAREFLRKKLINKKVQCNLDYISPPRENFPEKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDD 478
            ..:|..|:.        .||    ||         |                   :..|::..|:
Zfish  1234 GLEAEVFIS--------HCN----SP---------C-------------------SFFVQFATDE 1258

  Fly   479 DQRSSAYDQLIAAEQQAIKGLKGLHAKKDNATLRVNDLTV----DHSRIKVQYLPSWQRAL---- 535
            |...|..::| .|:|...:.:       |::.:...||..    |.|        ||.||:
Zfish  1259 DDIYSLVEKL-NADQSRCRNI-------DSSDIHEGDLVCAMFPDDS--------SWYRAVVRKN 1307

  Fly   536 RTEAI-VEFVASGSRLRIFVPKDSC-----LVTFLLAGISCPRSSRPALNGVPAQEGEPFGDEAL 594
            ..|.| ||||..|: ..:...|:.|     ..:|....|.|   |...|| |.::      |:.|
Zfish  1308 TNEKIDVEFVDFGN-TAVISSKNVCHLGQSFASFPRYSIHC---SVHKLN-VDSK------DQEL 1361

  Fly   595 TFTRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSGANLSVALVEEGLAEVHFSAEKSEYYRQLKI 659
            ....::||::::...|.|..|    :.|.:|       .|.|...|:  |..|..|.....::.|
Zfish  1362 APNFKQVLEQNIEKVICTFVK----MSGTMW-------EVRLDVNGV--VLGSVCKDHVKPEIAI 1413

  Fly   660 AEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKVVAERKVNYENVIVTEITETL----TFFAQS 720
            .:.:..|::..:.|.|             :..|..:.:        ::|..|..:    .|:.|.
Zfish  1414 PDLKDAASEIKVCTYY-------------KNPDISIGQ--------VITGYTSYIKGPQLFWCQY 1457

  Fly   721 VESGSKLESLMSKLHADFQSNPPIAGSYTPKR-----GDLVAAQFTLDNQWYRAKVERVQGSNAT 780
            | :..||:.:     :|...|...|...|.:.     |....|.||.||.||||||........:
Zfish  1458 V-AMDKLQEI-----SDMLQNIGNASETTLREDCMPVGSACIALFTEDNLWYRAKVTSKDLDTLS 1516

  Fly   781 VLYIDYGNKETLPTNRLAALPPAFSSEKPYATEYALALVALPTDNEDKEEALRAFSEDVLNHKVQ 845
            :.::||||:..:....:.||||..|...|:|.:..|....:.....| |.|..||.|  |.|...
Zfish  1517 ITFVDYGNESKVKIGDVKALPPKLSDVPPHAFDCQLEGFDVSEGFWD-ETADDAFYE--LVHDKP 1578

  Fly   846 LNVELKVTGS---PNLATL 861
            ||:.::..|:   |::..|
Zfish  1579 LNITIEKMGNSEMPHIVKL 1597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615
		SNc	195..333	CDD:214615	29/164 (18%)
		SNc	346..504	CDD:320778	29/167 (17%)
		SNc	538..672	CDD:214615	33/139 (24%)
		TUDOR	697..817	CDD:306940	34/128 (27%)
		SNc	767..914	CDD:320778	30/98 (31%)
tdrd6	XP_694024.6	Tudor_SF	6..132	CDD:413384
		Tudor_TDRD6_rpt2	233..361	CDD:410492
		Tudor_SF	482..613	CDD:413384
		Tudor_SF	705..828	CDD:413384
		Tudor_SF	917..1042	CDD:413384	10/48 (21%)
		Tudor_SF	1238..1349	CDD:413384	34/170 (20%)
		Tudor_SF	1440..1579	CDD:413384	43/147 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900