Protein Alignment Tudor-SN and Snd1

DIOPT Version :10

• Sequence 1: NP_612021.1
• Gene: Tudor-SN / 38045
• FlyBaseID: FBgn0035121
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_062750.2
• Gene: Snd1 / 56463
• MGIID: 1929266
• Length: 910
• Species: Mus musculus
• Alignment Length: 944
• Identity: 471/944 - (49%)
• Similarity: 633/944 - (67%)
• Gaps: 57/944 - (6%)

  Fly     1 MATAANTATAAGAAKDAPPAPTKSLSGIVKQVLSGDTVVIRA-TKGAPPPEKQITFSHVLAPKLA 64
            ||::|.::.::|    .|..||.. .||||.||||..:::|. .:|.||||:||..|::.|..||
Mouse     1 MASSAQSSGSSG----GPAVPTVQ-RGIVKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLA 60

  Fly    65 RRPGA---GGDETKDEPWAWESREFLRKKLIGVEVTFTFDKPANSNREYGFVWIGKDKETGENVV 126
            ||..|   .|.:|.|||||:.:||||||||||.||.||.:......||||.:::||| ..|||:.
Mouse    61 RRAAATQPDGKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKTPQGREYGMIYLGKD-TNGENIA 124

  Fly   127 ESIVREGLVSVRREG--RPTAEQQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLV 189
            ||:|.||| :.||||  ....||..|.|.|:||:|:.:|.|| ..:.:..:|::|::.|||.|.|
Mouse   125 ESLVAEGL-ATRREGMRANNPEQNRLSECEEQAKASKKGMWS-EGNGSHTIRDLKYTIENPRHFV 187

  Fly   190 DIYGGNPVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGVKLDADGK--PDLSVKVPFADE 252
            |.:...||.||||||||||.|||.|||..|.:|:|:|||:||..:.:.||.  |:     |||.|
Mouse   188 DSHHQKPVNAIIEHVRDGSVVRALLLPGHHLVTVMLSGIKCPTFRRETDGSETPE-----PFAAE 247

  Fly   253 ARYYVETRLLQRDVEIRLESVNNSNFIGTILYPKGNIAESLLREGLAKCVDWSMAVMKTGTDKLR 317
            |:::.|:|||||||:|.|||.:|.|.:||||:|.|||.|.||:||.|:|||||:||...|.:|||
Mouse   248 AKFFTESRLLQRDVQIILESCHNQNLLGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLR 312

  Fly   318 AAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFFSSIRPPR 382
            ||||||||:|||.|:||...|...:.|:|.|...|::|.|.|||.|:|::|..|.:..|||||||
Mouse   313 AAERFAKERRLRIWRDYVPPTANLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPR 377

  Fly   383 DQRAVVGTDGEEIVKAPPRGKNYRPLYEIPHMFDAREFLRKKLINKKVQCNLDYI---SPPRENF 444
                   .:|:.|   ..:.|..||||:||:||:||||||||||.|||...:|||   ||..|..
Mouse   378 -------LEGDNI---QDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATETV 432

  Fly   445 P---EKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKGLKGLHAKK 506
            |   |:.|.||:|||.|:|||:|:|||||.:|||||||||||.||:|:|||.:|||..||||:||
Mouse   433 PAFSERTCATVTIGGINIAEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKK 497

  Fly   507 DNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGISCP 571
            :....||.|::.|..:.| |:||..|||.|:||:||:|.|||||::::||::||:|||||||.||
Mouse   498 EVPIHRVADISGDTQKAK-QFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECP 561

  Fly   572 RSSR--PALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSGANLSV 634
            |.:|  |.|    .||||||.:||..||:|.||||:|.|.:::.|||| :.||||..| ||||||
Mouse   562 RGARNLPGL----VQEGEPFSEEATLFTKELVLQREVEVEVESMDKAG-NFIGWLHMD-GANLSV 620

  Fly   635 ALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKVVAERK 699
            .|||:.|::|||:||:|.||:.|..||:.||..|:.:|.:|.|...:|.....|||      ||.
Mouse   621 LLVEQALSKVHFTAERSAYYKPLLSAEEAAKQRKEKVWAHYEERPVEEVMPVLEEK------ERS 679

  Fly   700 VNYENVIVTEITETLTFFAQSVESGSKLESLMSKLHADFQSNPPIAGSYTPKRGDLVAAQFTLDN 764
            .:|:.|.|||||:.|.|:.|.||:|::||.||..:..|..|:||:.|||.|:||:...|:| :|.
Mouse   680 ASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRNDISSHPPVEGSYAPRRGEFCIAKF-VDG 743

  Fly   765 QWYRAKVERVQG-SNATVLYIDYGNKETLPTNRLAALPPAFSSE--KPYATEYALALVALPTDNE 826
            :||||:||:|:. :...|.||||||:|.||:.||..||||||:.  ...|||||.|.:.:|.|.:
Mouse   744 EWYRARVEKVESPAKVHVFYIDYGNREILPSTRLGTLPPAFSTRVLPAQATEYAFAFIQVPQDED 808

  Fly   827 DKEEALRAFSEDVLNHKVQLNVELKVTGSPNLATLRDPTTKVDFGKQLVAEGLVLAEQRGERKLK 891
            .:.:|:.:...|:.|.:..||||......|:: ||:...:|.|.|..||.||||:.|.|.|::.:
Mouse   809 ARTDAVDSVVRDIQNTQCLLNVEHLSASCPHV-TLQFADSKGDVGLGLVKEGLVMVEVRKEKQFQ 872

  Fly   892 ELVDQYKAAQEAARVAHLAIWKYGDITQDDAPEF 925
            :::.:|..|||:|:.|.|.:|:|||...|||.||
Mouse   873 KVITEYLNAQESAKSARLNLWRYGDFRADDADEF 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_612021.1	SNc	23..166	CDD:214615	73/148 (49%)
		SNc	195..333	CDD:214615	85/139 (61%)
		SNc	346..504	CDD:469627	90/163 (55%)
		SNc	538..672	CDD:214615	77/135 (57%)
		Tudor_TDRD11	723..805	CDD:410504	41/82 (50%)
		YncB	<868..926	CDD:441134	27/58 (47%)
Snd1	NP_062750.2	SNc	21..166	CDD:214615	75/147 (51%)
		SNc	193..328	CDD:214615	85/139 (61%)
		Nuclear localization signal. /evidence=ECO:0000255	321..325		2/3 (67%)
		SNc	350..496	CDD:238102	88/155 (57%)
		Nuclear localization signal. /evidence=ECO:0000255	388..392		1/3 (33%)
		SNc	525..660	CDD:214615	79/140 (56%)
		Tudor_TDRD11	703..785	CDD:410504	41/82 (50%)
		SNc	<844..895	CDD:469627	20/50 (40%)