DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and tdrd5

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_021325008.1	Gene:	tdrd5 / 557999	ZFINID:	ZDB-GENE-050208-502	Length:	908	Species:	Danio rerio

Alignment Length:	868	Identity:	157/868 - (18%)
Similarity:	261/868 - (30%)	Gaps:	310/868 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AGAAKDAPPAPTKSLSGIVKQVLSGDTVVIRATKGAPPPEKQITFSHVLAPKLARRPGAGGDETK 75
            ||..||.......|..|:..:.|..|   .::..|.|.|.:.:.|.:||            |..|
Zfish     8 AGLKKDVRSLLVSSKHGLTPEHLRRD---YQSMLGFPMPLRLLGFRNVL------------DMVK 57

  Fly    76 DEPWAWESREFLRKKLIGVEVTFTFDKPANSNREYGFVWIGKDKETGENVVESIVREGLVSVRRE 140
            :.|..             |.:.:..|         |.:.:   |..|::..:.|  |.|||.:|:
Zfish    58 EMPEV-------------VRLEYQLD---------GNIIL---KAIGDDTTKGI--EELVSKQRD 95

  Fly   141 GRPTAE----------------QQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLV 189
            .:|...                |..::....||:.|                       .||||
Zfish    96 HKPKPNNRKGKPGYFNISYPRLQPVILPRRGQAKPA-----------------------LPAHL- 136

  Fly   190 DIYGGNPVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGVKLDADGKPDLSVKVPFADEAR 254
                .:.:|.::.|    ..||...| :..|:...              ||| |:|     .:..
Zfish   137 ----RSQLKQLLSH----GPVRLSEL-ESRYVAQF--------------GKP-LNV-----TQYG 172

  Fly   255 YYVETRLLQ--RDVEIRLESVNNSNFIGTILYPKGNIAESLLREGLAKCVDWSMAVMKTGTDKLR 317
            ::..:.:|.  .|..|..:|...|..:........|..|:|:|.          ..|::.:.|.|
Zfish   173 FFSISEMLSAAMDFIIMQQSRTGSQLLLRSAVTPQNQPENLMRR----------FSMQSTSPKQR 227

  Fly   318 AAERFAKEKRLRQWQDYQAKTPAFNSK------EKDFSGTVVEVFNGDAINVRLSNGQVKKVFFS 376
            .|....|...|.:.:...:..|:..||      |:.|..||                      |.
Zfish   228 LAGFSPKASSLPERRPEVSLDPSSVSKPEPVKEEQSFEETV----------------------FK 270

  Fly   377 SIRPPRDQRAVVGTDG-------EEIVKAPPRGKNYRPLYEIPHMFDAREFLRKKLINKKVQCNL 434
            .....|.|....||.|       |::.|......|...::.:|                     .
Zfish   271 LEEELRQQILEKGTAGTVSQELKEKLRKVVAENGNGISIHNLP---------------------T 314

  Fly   435 DYISPPRENFPEKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKGL 499
            :|.....|..|...|     |..:|.|.:.|  |:..:..::..|:..|.:         .:...
Zfish   315 EYQRMHGEELPVSQC-----GFLSVTEMVGA--LSDTLAIQRGTDESESHW---------MVVEF 363

  Fly   500 KGLHAKKDNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTFL 564
            |.:..:.....|...|.|......::|. ||                 ||...|
Zfish   364 KPIDTQPCEPELSPGDGTTSSPTGELQN-PS-----------------SRAFYF----------- 399

  Fly   565 LAGISCPRSSRPALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSG 629
                |||.|:      ...:|.||..|.                                 .:|.
Zfish   400 ----SCPESA------WEHEETEPLTDS---------------------------------QESD 421

  Fly   630 ANLSVALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKV 694
            |.|.||     ...:|   :....:.:|.::.              |..||.:....::.|..
Zfish   422 AELRVA-----NKTIH---QMVNLFPELMVSR--------------VSAVPLDAVRCQKLKPP-- 462

  Fly   695 VAERKVNYENVIVTEITETLTF----FAQSVESGSKLESLMSKLHADFQSNPPIAGSY------- 748
             ..||......::.|.||:.::    |:|:.|:.: ||::|.::.:.: |.|.:|..|
Zfish   463 -VHRKERELLPVLVEQTESPSYFYIRFSQNKEARA-LENMMIEMRSCY-SYPDVAERYRLPDAYV 524

  Fly   749 TPKRGDLVAAQFTLDNQWYRAKVERV-QGSNATVLYIDYGNKETLPTNRLAALPPAFSSEKPYAT 812
            .|.:...||.:   |..:||..:..| ..:...|.|:|||:...:..:.|..|...::.....|.
Zfish   525 RPGQVCCVAPR---DMWFYRVVIHEVFSETEVKVYYVDYGDITKVERHSLRFLKACYADLPAQAV 586

  Fly   813 EYALALVALPTDNEDKEEALRAF 835
            ...||.|. |..|.....|:..|
Zfish   587 PAMLAGVR-PITNIWPASAVSCF 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	29/158 (18%)
		SNc	195..333	CDD:214615	26/139 (19%)
		SNc	346..504	CDD:320778	25/164 (15%)
		SNc	538..672	CDD:214615	18/133 (14%)
		TUDOR	697..817	CDD:306940	30/131 (23%)
		SNc	767..914	CDD:320778	18/70 (26%)
tdrd5	XP_021325008.1	LOTUS_1_TDRD5	3..97	CDD:193599	28/130 (22%)
		LOTUS_2_TDRD5	133..202	CDD:193589	20/98 (20%)
		LOTUS_3_TDRD5	289..364	CDD:193590	15/111 (14%)
		TUDOR	472..592	CDD:306940	29/124 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900