DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and tdrd1

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_021335784.1	Gene:	tdrd1 / 553522	ZFINID:	ZDB-GENE-070803-1	Length:	1201	Species:	Danio rerio

Alignment Length:	804	Identity:	156/804 - (19%)
Similarity:	280/804 - (34%)	Gaps:	252/804 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 PVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGVKLDADGKPDLSVKVPFADEARYYVETR 260
            |||...||     ::.:.|...|.... ..||    |...:::.:|...:.....|.  :.....
Zfish   386 PVKTQTEH-----SINSLLTASFENFK-RFSG----GKNENSEARPPEPLTQGVGDS--FTAVVT 438

  Fly   261 LLQRDVEIRLESVNNSNFIGTILYPKGNIAESLLREGLAKCVDWSMAVMKTGTDKLRAA------ 319
            .||...||..:.:.|::.|           :.|.......|.:      ...:|..|.|
Zfish   439 HLQSPSEILCQKLENASII-----------QQLQMNLRVHCSN------TAASDDFRPAPGTVCC 486

  Fly   320 ERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFFSSIRPPRDQ 384
            ..|:::   .||  |:||..|::|:::...|.:             ..|..::|..:.:||...:
Zfish   487 SLFSED---NQW--YRAKVLAYSSEDRVCVGYI-------------DFGNSEEVELNRLRPISKE 533

  Fly   385 RAVVGTDGEEI----VKAPPRGKNYRPLYEIPHMFDAREFLRKKLINKK----VQCNLDYISPPR 441
            ...:.|.....    :|:.....:...:..:.|:. ...|:|.:::.||    :...:|..|.|:
Zfish   534 LLALATQAIPCSLAGIKSLTDTWSDEAVLMLKHLV-CNRFIRVEILGKKDGRALVSMIDESSDPQ 597

  Fly   442 ENFPEKYCYTVSIGGQNVAEAMVAKGLATC----VRYRQDDDQRSSAYDQL----------IAAE 492
                           .:|.|.:|..|.|..    .:..:.|...|:....|          ..||
Zfish   598 ---------------ASVTELLVNMGFAAIESVETKKNEPDPATSTEIPPLSQPVVEKLEWTGAE 647

  Fly   493 --------QQAIKGLKGL-------HAKKDNATL-RVNDLTVDHSRI-KVQYLP----------- 529
                    :..|..||.|       ::|.|..|| .::...:.|... :..:.|
Zfish   648 LPFDGQKVELVISTLKSLDEFYCYNYSKTDEHTLTEMSFELMKHCESERAPFTPIVGEPCCALFT 712

  Fly   530 ---SWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGISCP------------------RS 573
               .|.||:    ::|....| :.|:      |.|.:   |.||.                  ::
Zfish   713 GDARWYRAM----VLEVCGEG-KARV------CFVDY---GNSCEVDAAHLKAITQSLLKLPFQA 763

  Fly   574 SRPALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGWLW--TDSGANLSVAL 636
            .|..|.||...||:        :.:|.:|:.....       ||..:.|.:.  |:.|..:.:..
Zfish   764 IRCWLAGVEPVEGQ--------WKKEAMLRFQALC-------AGQPLSGKVLSITEKGYGMELES 813

  Fly   637 VEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTE----EE-------- 689
            ..:.:|.|..|...::.|.|:: ...:.:.||.   .:.:|::|..|.:.:    ||
Zfish   814 AGQTVASVLISEHLAKPYGQVR-QPPQIQPAKP---ASQIEDLPSLKPIDQNPSVEEPLKVSSKG 874

  Fly   690 ----KEDKVVAER--KVNYENV-----------IVTEITETLTFFAQ----SVESGSKLESLMSK 733
                .||..|:..  .:|::.:           :...|:.:|.:...    :||.   |:::|:.
Zfish   875 AATTPEDLPVSSGCFPLNWKTLELSCSGTFQPRVAAVISPSLFYIMNPGQVNVEG---LKAVMTD 936

  Fly   734 LHADFQSNPPIAGSYTPKRGDLVAAQFTLDNQWYRAKVERVQGSNATVLYIDYGNKETLPTNRLA 798
            : |.:.|..|:.....|..|....|||:.|..||||.|..|...:|.|:|.||||.||:|.:.:
Zfish   937 V-AKYCSKQPVPNQCHPLPGASCCAQFSGDKNWYRAVVLEVTTKHAHVIYSDYGNMETVPLSSI- 999

  Fly   799 ALPPAFSSEKPYATEYALALVALPTDNEDKEEALRAFSEDVLNHKVQLNVELKVTGSPNLATLRD 863
                                  ||            .::::|.|..|: |...:||..:...:.
Zfish  1000 ----------------------LP------------ITKELLQHPFQI-VRCALTGKEHFPVVW- 1028

  Fly   864 PTTKVD-FGKQLVAEGLVLAEQRG 886
            ||..:: ||.||  .|.|||..:|
Zfish  1029 PTEVLELFGIQL--SGGVLASFQG 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615
		SNc	195..333	CDD:214615	26/142 (18%)
		SNc	346..504	CDD:320778	29/194 (15%)
		SNc	538..672	CDD:214615	28/153 (18%)
		TUDOR	697..817	CDD:306940	32/136 (24%)
		SNc	767..914	CDD:320778	34/121 (28%)
tdrd1	XP_021335784.1	zf-MYND	83..119	CDD:307734
		TUDOR	210..318	CDD:306940
		TUDOR	429..548	CDD:306940	26/155 (17%)
		TUDOR	652..770	CDD:306940	23/131 (18%)
		TUDOR	908..1020	CDD:306940	37/151 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900