DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tudor-SN and rnf17

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_021334643.1	Gene:	rnf17 / 334519	ZFINID:	ZDB-GENE-030131-6451	Length:	1521	Species:	Danio rerio

Alignment Length:	993	Identity:	186/993 - (18%)
Similarity:	322/993 - (32%)	Gaps:	360/993 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KDEPWAWESREFLRKKLIGVEVTFTFDKPANSN----------------REYGFVWIGKDKETGE 123
            ||:.|.            .|:||..|.|....:                .:|||.       .|
Zfish   451 KDDMWC------------RVKVTELFQKECFQSVTKCLASEVSRLCVYFLDYGFF-------KG- 495

  Fly   124 NVVESIVREGLVSVRREGRPTAEQQTLIELEDQARAAGRGKWSPTA------------------- 169
               .||..:|.:|...|.....:..||||:         ..|:|.|
Zfish   496 ---FSIPSDGGLSGLNECLRRPDGITLIEM---------ANWAPLAIKCSLKDIIPADLVKGWSS 548

  Fly   170 SAADKVRNI---------KWSHENPAHLVDIYGGNPVKAIIEHVRDGSTVRAFLLPDFHYITLMI 225
            .|::::||:         .:..:..|.|||:     .|..:..::..|.|.   |.: |.:.:.:
Zfish   549 EASEEMRNVLRNETAEMQVFGEDGDALLVDL-----KKTSMADLKKNSMVS---LRE-HLVFMEL 604

  Fly   226 SGIRCPGVKLDA-------DGKPDLSVKV---------PFADEARYYVETRLLQRDVEI-----R 269
            :...||.:...:       ..:|.|:|:|         |    :.:||:   |..:.|.     :
Zfish   605 ARFYCPVITTGSAPLLFYPSVQPSLNVEVNAMVSHVNTP----SDFYVQ---LVENTEYPLLHSK 662

  Fly   270 LESVNNSNFIGTILYPKGNIAESLLREGLAK-CV-----DWSMAVMKTGTDKLRAAE-------- 320
            |:...|.        ||.|....:....|:: ||     :|| .|..||....|..|
Zfish   663 LQDCYNQ--------PKSNNECQVYCPSLSQACVAFHDQEWS-RVQVTGFPGGRMVEVRFVDFGY 718

  Fly   321 -RFAKEKRLRQWQDYQAKTPAFN---------SKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFF 375
             |....|.||..:|.....|...         |.::.::....|.|. :.:..:|.....||...
Zfish   719 KRTLSVKDLRHIKDEFFVLPEMALWCNLNDVISSQETWANEACESFK-ELVEGKLMTVVAKKNVP 782

  Fly   376 SSIRPPRDQRAVVGTD------GEEIVKA-----------------------PPRGKNYRPLYEI 411
            || :|.......:..|      |:|:||.                       ||..:...|:...
Zfish   783 SS-KPVPVCLFEISDDCTGASIGDELVKKGYAVYNKDTQVRDAQPLETTSWDPPFEEEALPVVMT 846

  Fly   412 PHMFDAREFLRKKL----INKKVQCNLDYISPPRENFPEKYCYTVSIGGQNVAEAMVAKGLATCV 472
            |.  .|.|.|:..|    ..|.::..:.:::.|                .|:           ||
Zfish   847 PS--SASEELKPSLSLPSCLKDIRVRVTHVTSP----------------GNI-----------CV 882

  Fly   473 RYRQDDDQRSSAYDQLIAAEQQAIKGLKGLHAKKDNATLR--------VNDLTVDHSRIKVQYLP 529
            :..|.|:|....:|.           ||.|.:|.:...::        ||:..|
Zfish   883 QLLQFDNQLKRIHDT-----------LKNLFSKSEPQEMQWEAEMYCAVNNTGV----------- 925

  Fly   530 SWQR----ALRTEAIVEFVAS--GSRLRIFV----PKDSCLV-TFLLAGISCPRSSRPALNGVPA 583
             |:|    ::.|..:.|.:..  |:.:::.|    |....|: :|||   .|      .|:||..
Zfish   926 -WERGQVCSVSTCGVAEVLRCDFGNTVKLHVDNLRPLHPDLIGSFLL---EC------NLSGVRP 980

  Fly   584 QEGEP--------------FGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSGANLSV 634
            ..|..              .|..||...:| ...|.|.|.:..:::||.            |:|.
Zfish   981 AGGRSTWTATACDFISHYLTGAMALMAIKE-PSTRPVLVSLFCSNRAGQ------------NVSF 1032

  Fly   635 A--LVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKV--- 694
            |  |:.||||                :.|.:|            |.|..|::|...|.:..:
Zfish  1033 ADFLISEGLA----------------LKERKA------------EMVFSEESVLVTEPQPVISPT 1069

  Fly   695 ----VAERKVN--------------------YENVIVTEITETLTFFAQSVESGSKLESLMSKLH 735
                ...|::|                    :..:.::.::|....:|.:.::..:.:.|..:|.
Zfish  1070 QTPPTPSRRINPPPERVKTHSYPPPELPPCGHILMSISAVSEQGVIYAMTHQAVCEFDRLRERLQ 1134

  Fly   736 ADFQSNPPIAGSYTPKRGDLVAAQFTLDNQWYRAKVERVQGSNATVLYIDYGNKETLPTNRLAAL 800
            ...::.|. ..:|..| |.|..|....|..|||.:|:.|.|.:..|.|:|.|..|::|...:  .
Zfish  1135 QHIKTLPR-QKNYNWK-GVLGCAVMGTDMFWYRGQVQEVIGGHVKVRYVDQGLVESIPVCHV--Y 1195

  Fly   801 PPAFSSEKPYATEYALALVALPTDNEDKEEALRAFSEDVLNHKVQLNVELKVTGSPNLATLRDPT 865
            |.....:.|...........||.....:.:|:....|.:|...|  ||::       :...:||.
Zfish  1196 PMVLCEDVPQLCVPCQINGVLPIGKGWQWDAVVLMKELLLGRSV--NVQI-------MEHPKDPC 1251

  Fly   866 TKVDFGKQLVAEGLVLAE 883
            ..|..  :::.:|:.|::
Zfish  1252 GCVTV--EIMVDGMALSK 1267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	21/106 (20%)
		SNc	195..333	CDD:214615	35/173 (20%)
		SNc	346..504	CDD:320778	33/190 (17%)
		SNc	538..672	CDD:214615	32/156 (21%)
		TUDOR	697..817	CDD:306940	27/139 (19%)
		SNc	767..914	CDD:320778	26/117 (22%)
rnf17	XP_021334643.1	RING_Ubox	8..60	CDD:327409
		TUDOR	394..534	CDD:306940	24/114 (21%)
		TUDOR	633..746	CDD:306940	27/128 (21%)
		TUDOR	865..977	CDD:306940	29/170 (17%)
		TUDOR	1092..1214	CDD:306940	25/125 (20%)
		TUDOR	1326..1450	CDD:306940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900