DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and Tdrd6

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001178512.1	Gene:	Tdrd6 / 316254	RGDID:	1305956	Length:	2136	Species:	Rattus norvegicus

Alignment Length:	961	Identity:	184/961 - (19%)
Similarity:	337/961 - (35%)	Gaps:	306/961 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GLVSVRREGRPTAEQQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLVDIYGG--- 194
            |||..||      |:...:..|.|..||.||.|:...::|           :|..|..:..|
  Rat    34 GLVGQRR------EEYVRLSREIQEAAATRGPWALGGASA-----------SPGELCLVQVGLMW 81

  Fly   195 NPVKAIIEHVRDGSTVRAFLLPDFHYIT----------------------LMISGIRCPGVKLDA 237
            :..:.:....:|.   |.|||.:...||                      .:::|:...|.....
  Rat    82 HRCRVVSRQAQDS---RVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGGGGAG 143

  Fly   238 DGKP--------DLSVKVPFADEARYYVETRLLQRDVEIRLESVNNS-NFIGTILYPKGNIAESL 293
            .|:|        |....:...:.....::..||.|.|.:.:..|:.. ..:|...:...::..||
  Rat   144 GGEPQHWSPNAVDFLSNLQGKEVHGRVLDVLLLHRLVLLEVPVVSQQMEELGLARHVPDSLFCSL 208

  Fly   294 LREGLAKCVDWSMAVMKTGTDKL-RAAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVV--EV 355
            |:..|.     :..:..:|...| |||.:          |::......:...:...:..||  :|
  Rat   209 LKRYLT-----AAGLGSSGAPVLPRAAPK----------QEHPGLDYFYPQLQLGVTEPVVVTQV 258

  Fly   356 FNGDAINVRLSNGQVKKVFFSSIRPPRDQRAVVGTDG--------EEIVKAPPR----------- 401
            .:...|:.:| ....:::...|....:..||..||:.        ||..::|.:
  Rat   259 CHPHRIHCQL-RSLSQEIHRLSESMAQVYRAPTGTEDEDSGSATWEEREESPDKPGSPCASCGLD 322

  Fly   402 GKNYRPLY----------EIPHMFDAREFLRKKLINKKVQC-NLDYISP-----PRENFP----- 445
            |:.||.|.          ::.|:    ::.||:|    |.| :|.|:.|     |...:|
  Rat   323 GQWYRALLLETFRPQRCAQVLHV----DYGRKEL----VSCSSLRYLLPEYFRMPVVTYPCALYG 379

  Fly   446 -----------------------------EKYC-----YTVSIGGQNVAEAMVAKGLATCV---R 473
                                         |.||     |.|::.|::......|.|:.:|.   |
  Rat   380 LWDCGRGWSRSQVGDLKALILGQAVNAKIEFYCSFEHMYYVTLYGEDGINLNSAFGVQSCCLADR 444

  Fly   474 YRQ----------DDDQRSSAYDQLIAAEQQ----AIKGLKGLHAKKDNATLRVNDLTVDHSRIK 524
            :.|          |:|:..:|:.....||:.    ::..|:.:..|.:         |...::::
  Rat   445 FLQSQGIEEEEDEDEDEMEAAFQSQSPAEEMEEEVSLPSLRSIRLKMN---------TFYDAQVE 500

  Fly   525 VQYLPS--WQRALR--------TEAIVEFVASGSRLRIFV----PKDSCLV-------------- 561
            ....||  |.|..:        |:.:..|.:|.|:|...:    |.|.|.|
  Rat   501 FVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILKPEPDDLCCVKWKENGYYRAMVTR 565

  Fly   562 -------TFLL-AGIS-----CP-RSSRPALNGVPAQE-----------GEPFGDEALTFTRERV 601
                   .||: .|.|     |. |...|....:|...           |:.:..||::|.::.|
  Rat   566 LDSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEAISFFKKTV 630

  Fly   602 LQRDVSVHIDTTDKAGSSVIGWLWTDSGA---NLSVALVEEGLAEV------------------- 644
            |.:::.|||  .||.....:..:..:|..   |:|..:.:.|.|:.
  Rat   631 LHKELVVHI--LDKQDRQYVIEILDESRTGEENISKVIAQAGYAKFQEFETKENIRLSAHSPGHV 693

  Fly   645 --HFSAEKSEYYRQLKIAEDRAKAAKKN--------IWTNYVEEVPKEKTVTEEEKEDKVVAERK 699
              ||.||.|:.....|:..|: ||...|        :.|..:..:...:|..::|   ||.::..
  Rat   694 SGHFIAESSKIPSVKKVEGDQ-KAKNDNKTLSDPEALATVSLSNISTGQTAQDKE---KVTSDPT 754

  Fly   700 VNYENVIVT----------EITETL-----------TFFAQSVESGSKLESLMSKLHADFQSNPP 743
            :...|::.|          |:..|:           :|:.|.:.:.....:||..:....:|.|
  Rat   755 LLMLNLLKTKPDCCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSEP- 818

  Fly   744 IAGSYTPKRGDLVA--AQFTLDNQWYRAKVERVQG-SNATVLYIDYGNKETLPTNRLAALPPAFS 805
                 :|..||..|  |:.|.:.:|.||.:...|. .:..|:::|||:|:.:....:.::...|.
  Rat   819 -----SPYEGDTRACLAKRTANGRWSRALISGAQSLEHVRVVFVDYGDKDVVSMKDILSVSDVFF 878

  Fly   806 SEKPYATEYALALVALPTDNED---KEEALRAFSEDVLNHKVQLNVELKVT 853
            ..:..|...:|..:..||....   .|.|::||: ..:::..|.|:|||.|
  Rat   879 KVRAQAFRCSLYNLIQPTGENPFVWDERAIQAFT-GFIDNAWQNNLELKCT 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	12/32 (38%)
		SNc	195..333	CDD:214615	27/169 (16%)
		SNc	346..504	CDD:320778	45/250 (18%)
		SNc	538..672	CDD:214615	42/208 (20%)
		TUDOR	697..817	CDD:306940	27/143 (19%)
		SNc	767..914	CDD:320778	23/91 (25%)
Tdrd6	NP_001178512.1	TUDOR	10..133	CDD:278965	24/118 (20%)
		TUDOR	245..379	CDD:278965	28/142 (20%)
		TUDOR	313..359	CDD:119391	10/53 (19%)
		TUDOR	489..610	CDD:278965	23/129 (18%)
		TUDOR	547..591	CDD:119391	8/43 (19%)
		TUDOR	775..891	CDD:278965	25/121 (21%)
		TUDOR	827..870	CDD:119391	12/42 (29%)
		TUDOR	988..1107	CDD:278965
		TUDOR	1043..1085	CDD:119391
		TUDOR	1310..1429	CDD:278965
		TUDOR	1363..1407	CDD:119391
		TUDOR	1523..1645	CDD:278965
		TUDOR	1578..>1616	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900