DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and Rnf17

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001028215.1	Gene:	Rnf17 / 30054	MGIID:	1353419	Length:	1640	Species:	Mus musculus

Alignment Length:	1068	Identity:	200/1068 - (18%)
Similarity:	350/1068 - (32%)	Gaps:	385/1068 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VKQVLSGDTVVI-----RATKG--APPPEKQITFSHVLAPKLARRPGAGGDETKDEPWAWESREF 86
            ||.|..|:|..|     |..|.  ..||||.|..      |||.     .:.:|...|:.:::|.
Mouse   783 VKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKC------KLAY-----VEPSKKSQWSKKAKEK 836

  Fly    87 LRKKLIGVEVTFTFDKPANSNREYGFVWIGKDKETGENVV---ESIVREGLVSVRREGRPTAEQQ 148
            ..:|.....||.:..|...:|  ...|.:...:..|::.|   :.:|:|||.|.  |...|.:..
Mouse   837 FEEKTQDKFVTCSVIKILENN--VLLVELFDSRAPGKSAVSINDQLVKEGLASY--EAGYTLKDN 897

  Fly   149 TLIELEDQARAAGRGKW--SPTASAADKVRNIK---------------WSHENPAHLVDIYGGNP 196
            :...||         .|  ||......::.|:.               ::.|.|.::.::.  :|
Mouse   898 SKKHLE---------VWDPSPEEIITSEINNLSPLSVKSLPNENFQSLYNKELPVNICNVI--SP 951

  Fly   197 VKAIIEHVRDGSTVRAFLLPDFHYITL---MISGIRCPGVKLDADGKP-----DL--SVKVPFAD 251
            .|..::          :||.:....:|   |::...      .::.||     |:  :||||..:
Mouse   952 EKIYVQ----------WLLTENLLNSLEEKMVAAYE------HSEWKPVKWECDMHCAVKVPAKN 1000

  Fly   252 EAR----------YYVETRLLQRDVEI------------------RLE----------------- 271
            :.|          ..||..|....||:                  ||.
Mouse  1001 QWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGGSDKW 1065

  Fly   272 --------SVNNSNFIGTILYPKGNIAESL-----LREGLAKCVDWSMAVMKTGTDKLRAAERFA 323
                    |::.:..|.||:..:.|....|     .|:...:.||.|..::|.|.        ..
Mouse  1066 TATACDCLSLHLTGAIATIILQESNTTWPLPVKIFCRDEKGERVDVSKYLIKKGL--------AL 1122

  Fly   324 KEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFFSSIRPPRD---QR 385
            :|:|:       :|:...:|.||...   :.:..||::..:..     |:.|.:.:...|   :.
Mouse  1123 RERRV-------SKSSNSHSPEKSLE---IPLEQGDSVVTKCF-----KINFDTNKKIADKVNEH 1172

  Fly   386 AVVGTDGEEIVKAPPRGKN-YRP---------------------LYEIPHMFDAREFLRKKLINK 428
            .|..:.|:   |:..|... |||                     ::.:|.:   .||...|:::
Mouse  1173 KVPDSKGK---KSESRSTGCYRPPAVPNTSSFEAIVTCIGDDGTIFVVPKL---SEFELIKMMD- 1230

  Fly   429 KVQCNLDYISPPRENFPEKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQ 493
            ::|.||..:     ...|.|.:              .||                        |.
Mouse  1231 EIQSNLKCL-----GLLEPYSW--------------KKG------------------------EP 1252

  Fly   494 QAIKGLKGLHAKKDNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDS 558
            .|::|       .|....|...:.|....|:||||...    .||.|.:
Mouse  1253 CAVRG-------SDTLWYRGKVMEVVGGTIRVQYLDHG----FTEKIPQ---------------- 1290

  Fly   559 CLVTFLLAGISCPRSSRPALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGW 623
            |.:..:|.....|:...|.........|..:..:|:...:|.:.:|:|.:||..
Mouse  1291 CHLYPILLYPDTPQFCIPCQLYQTLPVGNTWQPDAIELLQELLSKREVDIHIME----------- 1344

  Fly   624 LWTDSGANLSVALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEE 688
            |..:|...|||.|..:|::..||.|     :.:..|.|             :.||:.|||...:.
Mouse  1345 LPNNSWGKLSVHLYFDGMSLSHFMA-----HHKYCIFE-------------HTEEIFKEKPRGQN 1391

  Fly   689 EK-EDKVVAERKVNYENVIVTEITETL-------------TFFAQSV------------------ 721
            :| ||:   ..|:.:|::::.|:...:             ..||..|
Mouse  1392 KKYEDE---NWKIRFEDLLLPEMEAPVLPPYLSSLLPPPEELFAVQVKHIVSPDEMYICLDSEDS 1453

  Fly   722 -----------ESG-------SKLESLMSKLHADFQSNPPIAGSYTPKRGDLVAAQFTLDNQWYR 768
                       :||       ..||..:.:.:.:.::.||:    |....::.......|..|||
Mouse  1454 YTQFNHHGDTDDSGVSWESESENLEEALQRFNKNVETFPPL----TDFSSEMPCLAEYADGLWYR 1514

  Fly   769 AKVERVQGSN---ATVLYIDYGNKETLPTNRLAALPPAFSSEKPYATEYALALVALPTDNEDKEE 830
            ||:..::..|   ..||::|||..|.|..|||..:|.........|.:..||....|..:..|
Mouse  1515 AKIISIKEFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPPLSDSGK-- 1577

  Fly   831 ALRAFSEDVLNHKVQLNVELKVTGSPNLATLRDPTTKVDF--GKQLVAEGLVLAEQRGERKLKEL 893
                               .::...|.. ::....|.:|.  ||||.|..:..|.:       ::
Mouse  1578 -------------------TRIPYCPKW-SMEALWTMIDCLQGKQLYASSVAQAPE-------QI 1615

  Fly   894 VDQYKAAQEAARVAHLAIWKYGDITQDD 921
            |..|:..|..   .|:::.:.|...:|:
Mouse  1616 VTLYEDEQYP---VHMSLVEMGLADKDE 1640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	37/148 (25%)
		SNc	195..333	CDD:214615	35/205 (17%)
		SNc	346..504	CDD:320778	27/182 (15%)
		SNc	538..672	CDD:214615	25/133 (19%)
		TUDOR	697..817	CDD:306940	32/171 (19%)
		SNc	767..914	CDD:320778	34/151 (23%)
Rnf17	NP_001028215.1	iSH2_PI3K_IA_R	158..>242	CDD:304922
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..376
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..435
		TUDOR	444..>551	CDD:278965
		TUDOR	698..819	CDD:278965	14/41 (34%)
		TUDOR	755..801	CDD:119391	6/17 (35%)
		TUDOR	937..1053	CDD:278965	23/133 (17%)
		TUDOR	990..1036	CDD:119391	10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1191		4/23 (17%)
		TUDOR	1196..1312	CDD:278965	29/189 (15%)
		TUDOR	1250..1295	CDD:119391	16/95 (17%)
		TUDOR	1426..1567	CDD:278965	30/144 (21%)
		TUDOR	1501..1548	CDD:119391	17/46 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900