DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and Tdrd1

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_038959137.1	Gene:	Tdrd1 / 292129	RGDID:	1306140	Length:	1174	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	178/877 - (20%)
Similarity:	291/877 - (33%)	Gaps:	265/877 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 FTFDKPANSNREYGFVWIGKDKE-TGENVVESIVREGLVSVRRE-GRPTAEQQTLIELEDQARAA 160
            |....|.|.|::..|:...::|: .......|:|......:..| |....:::||......:.:.
  Rat    45 FRLKSPENGNKKNNFLLCEQNKQYLASQEDNSVVSSNPAGINGEVGGSKGDRKTLPTGNPVSLSL 109

  Fly   161 GRGKWSPTASAADKVRNI------KWSHE---------NPAHLVDIYGGNPVKAIIEHVRDGSTV 210
            |..  ||......|..|.      |.||:         |||....:  |.|:::...| |.|
  Rat   110 GNN--SPPNQVKTKPSNAVTPEKSKKSHKLFENALSVNNPALFNSL--GPPLRSTTCH-RCG--- 166

  Fly   211 RAFLLPDFHYITLMISGIRCPGVKLDADGKPDLSVKVPFADEARYYVETRLLQRDVEIRLESVNN 275
                         :...:||...|                  ..||..|...:||....
  Rat   167 -------------LFGSLRCSQCK------------------QTYYCSTACQRRDWSSH------ 194

  Fly   276 SNFIGTILYPKGNIAESLLREGLAKCVDWSMAVMKTGTDKLRAAERFAKEKRLRQWQDYQAKTPA 340
                .||..|        :::.|.|..|                                .|:|
  Rat   195 ----STICRP--------VQQSLHKLED--------------------------------NKSP- 214

  Fly   341 FNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFFSSIR--PPRDQRAVVGTDGEEIVKAPPRGK 403
            |.:|..|.....|....|  :...::.| .::|.||.:|  ..|....:.||..|  .|.|  |.
  Rat   215 FETKTIDVKNEQVACPLG--VTKEMTAG-AERVMFSDLRSLQLRKSMEIKGTVTE--FKHP--GH 272

  Fly   404 NYRPLYEIPHMFDAREFLRKKLINKKVQCNLDYISPPRENFPEKYCYTVSIGGQNVAEAMVAKGL 468
            .|..||                 :.:|   |:|::....:..|.|...|...|.     :..||.
  Rat   273 FYVQLY-----------------SSEV---LEYMNQLSASLKETYANMVPEDGY-----LPVKGE 312

  Fly   469 ATCVRYRQDDDQRSSAYDQLIAAEQQAIKGLKGLHAKKDNATLRVNDLTVDHSRIKVQYLPSWQR 533
            ....:|                                          |||.         :|.|
  Rat   313 VCVAKY------------------------------------------TVDQ---------TWNR 326

  Fly   534 A-------LRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGISC--PRSSRPALNGVPAQEGEPF 589
            |       |:.:|.|.::..|:  ...:|.|.  :..|...||.  |.:.:..::||....|| :
  Rat   327 AVVEGVDVLQKKAHVLYIDYGN--EEIIPVDR--IHQLSRSISLFPPSAIKCYVSGVVPAAGE-W 386

  Fly   590 GDEALTFTRERVLQRDVSVH-IDTTDKAG-SSVIGWLWTDSGANLSVALVEEGLAEVHFSAEKSE 652
            .::.:...:..:.::..|:. :|.:::.| :..:..:...||..|...|||.|..
  Rat   387 TEDCVVAVKALLFEQYCSIKVVDISEEEGLTCAVDVVLQSSGKQLDHVLVEMGYG---------- 441

  Fly   653 YYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKVVAERKVNYENV-----------I 706
                  :..|...:.|:::.....|:..:...      |:::.|||......|           :
  Rat   442 ------VKPDEPSSKKQSMDPGTSEDTGRLTA------ENRIGAERNALVPTVLTLNVGDEFCGV 494

  Fly   707 VTEITETLTFFAQSVESGSKLESLMSKLHADFQSNPPIAGSYTPKRGDLVAAQFTLDNQWYRAKV 771
            |..|.....||.|.::||.||..|...| :::.|:......:.|..||:..|||:.|:|||||.|
  Rat   495 VAHIQTPEDFFCQQLQSGHKLAELQESL-SEYCSHVTPRSDFYPTIGDMCCAQFSEDDQWYRASV 558

  Fly   772 ERVQGSNATVL--YIDYGNKETLPTNRLAALPPAFSSEKPYATEYALALVALPTDNEDKEEALRA 834
             ....|..:||  |:||||.|.|...||..:.|........|....||.|. |:......||:..
  Rat   559 -LAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVK-PSLGMWTPEAICV 621

  Fly   835 FSEDVLNHKVQLNVELKVTGSPNLATLRDPTT--KVDFGKQLVAEGLVLAEQRGERKLKELVDQY 897
            ..:.|.|..|.:.| :.:.|:..|..|.|.:.  .:...|.|:..|..:.|       |::|...
  Rat   622 MRKAVQNRMVTVRV-VGMQGTRALVELVDKSVAPHLSASKALLDSGFAIEE-------KDIVADK 678

  Fly   898 KAAQEAARVAHLAI--------WKYGDITQDD 921
            .::..|:.|. ||:        |.:.:.|.|:
  Rat   679 GSSARASNVP-LAVEGAVEVLEWTWVEFTVDE 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	13/69 (19%)
		SNc	195..333	CDD:214615	18/137 (13%)
		SNc	346..504	CDD:320778	28/159 (18%)
		SNc	538..672	CDD:214615	25/137 (18%)
		TUDOR	697..817	CDD:306940	42/132 (32%)
		SNc	767..914	CDD:320778	43/158 (27%)
Tdrd1	XP_038959137.1	zf-MYND	162..198	CDD:396356	12/80 (15%)
		Tudor_TDRD1_rpt1	262..391	CDD:410479	39/213 (18%)
		Tudor_TDRD1_rpt2	512..593	CDD:410480	32/82 (39%)
		TUDOR	709..825	CDD:395449	0/1 (0%)
		Tudor_SF	938..1053	CDD:413384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810