DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and SND1

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_055205.2	Gene:	SND1 / 27044	HGNCID:	30646	Length:	910	Species:	Homo sapiens

Alignment Length:	944	Identity:	472/944 - (50%)
Similarity:	634/944 - (67%)	Gaps:	57/944 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATAANTATAAGAAKDAPPAPTKSLSGIVKQVLSGDTVVIRA-TKGAPPPEKQITFSHVLAPKLA 64
            ||::|.    :|.:...|..||.. .||:|.||||..:::|. .:|.||||:||..|::.|..||
Human     1 MASSAQ----SGGSSGGPAVPTVQ-RGIIKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLA 60

  Fly    65 RRPGA---GGDETKDEPWAWESREFLRKKLIGVEVTFTFDKPANSNREYGFVWIGKDKETGENVV 126
            ||..|   ...:|.|||||:.:||||||||||.||.||.:......||||.:::||| ..|||:.
Human    61 RRAAATQPDAKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKTPQGREYGMIYLGKD-TNGENIA 124

  Fly   127 ESIVREGLVSVRREG--RPTAEQQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLV 189
            ||:|.||| :.||||  ....||..|.|.|:||:||.:|.|| ..:.:..:|::|::.|||.|.|
Human   125 ESLVAEGL-ATRREGMRANNPEQNRLSECEEQAKAAKKGMWS-EGNGSHTIRDLKYTIENPRHFV 187

  Fly   190 DIYGGNPVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGVKLDADGK--PDLSVKVPFADE 252
            |.:...||.||||||||||.|||.||||::.:|:|:|||:||..:.:|||.  |:     |||.|
Human   188 DSHHQKPVNAIIEHVRDGSVVRALLLPDYYLVTVMLSGIKCPTFRREADGSETPE-----PFAAE 247

  Fly   253 ARYYVETRLLQRDVEIRLESVNNSNFIGTILYPKGNIAESLLREGLAKCVDWSMAVMKTGTDKLR 317
            |:::.|:|||||||:|.|||.:|.|.:||||:|.|||.|.||:||.|:|||||:||...|.:|||
Human   248 AKFFTESRLLQRDVQIILESCHNQNILGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLR 312

  Fly   318 AAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFFSSIRPPR 382
            ||||||||:|||.|:||.|.|...:.|:|.|...|::|.|.|||.|:|::|..|.:..|||||||
Human   313 AAERFAKERRLRIWRDYVAPTANLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPR 377

  Fly   383 DQRAVVGTDGEEIVKAPPRGKNYRPLYEIPHMFDAREFLRKKLINKKVQCNLDYI---SPPRENF 444
                   .:||   ....:.|..||||:||:||:||||||||||.|||...:|||   ||..|..
Human   378 -------LEGE---NTQDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATETV 432

  Fly   445 P---EKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKGLKGLHAKK 506
            |   |:.|.||:|||.|:|||:|:|||||.:|||||||||||.||:|:|||.:|||..||||:||
Human   433 PAFSERTCATVTIGGINIAEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKK 497

  Fly   507 DNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGISCP 571
            :....||.|::.|..:.| |:||..|||.|:||:||:|.|||||::::||::||:|||||||.||
Human   498 EVPIHRVADISGDTQKAK-QFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECP 561

  Fly   572 RSSR--PALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSGANLSV 634
            |.:|  |.|    .||||||.:||..||:|.||||:|.|.:::.|||| :.||||..| ||||||
Human   562 RGARNLPGL----VQEGEPFSEEATLFTKELVLQREVEVEVESMDKAG-NFIGWLHID-GANLSV 620

  Fly   635 ALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKVVAERK 699
            .|||..|::|||:||:|.||:.|..||:.||..|:.:|.:|.|:..:|.....|||      ||.
Human   621 LLVEHALSKVHFTAERSSYYKSLLSAEEAAKQKKEKVWAHYEEQPVEEVMPVLEEK------ERS 679

  Fly   700 VNYENVIVTEITETLTFFAQSVESGSKLESLMSKLHADFQSNPPIAGSYTPKRGDLVAAQFTLDN 764
            .:|:.|.|||||:.|.|:.|.||:|::||.||..:..|..|:||:.|||.|:||:...|:| :|.
Human   680 ASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKF-VDG 743

  Fly   765 QWYRAKVERVQG-SNATVLYIDYGNKETLPTNRLAALPPAFSSE--KPYATEYALALVALPTDNE 826
            :||||:||:|:. :...|.||||||:|.||:.||..|.||||:.  ...|||||.|.:.:|.|::
Human   744 EWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLSPAFSTRVLPAQATEYAFAFIQVPQDDD 808

  Fly   827 DKEEALRAFSEDVLNHKVQLNVELKVTGSPNLATLRDPTTKVDFGKQLVAEGLVLAEQRGERKLK 891
            .:.:|:.:...|:.|.:..||||....|.|:: ||:...:|.|.|..||.||||:.|.|.|::.:
Human   809 ARTDAVDSVVRDIQNTQCLLNVEHLSAGCPHV-TLQFADSKGDVGLGLVKEGLVMVEVRKEKQFQ 872

  Fly   892 ELVDQYKAAQEAARVAHLAIWKYGDITQDDAPEF 925
            :::.:|..|||:|:.|.|.:|:|||...|||.||
Human   873 KVITEYLNAQESAKSARLNLWRYGDFRADDADEF 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	72/148 (49%)
		SNc	195..333	CDD:214615	86/139 (62%)
		SNc	346..504	CDD:320778	90/163 (55%)
		SNc	538..672	CDD:214615	77/135 (57%)
		TUDOR	697..817	CDD:306940	61/122 (50%)
		SNc	767..914	CDD:320778	62/149 (42%)
SND1	NP_055205.2	SNc	21..166	CDD:214615	74/147 (50%)
		SNc	26..166	CDD:238102	71/142 (50%)
		SNc	193..328	CDD:214615	86/139 (62%)
		SNc	201..328	CDD:238102	80/131 (61%)
		Nuclear localization signal. /evidence=ECO:0000255	321..325		2/3 (67%)
		SNc	341..495	CDD:214615	90/163 (55%)
		SNc	350..496	CDD:238102	88/155 (57%)
		Nuclear localization signal. /evidence=ECO:0000255	388..392		1/3 (33%)
		SNc	525..660	CDD:214615	79/140 (56%)
		SNc	533..660	CDD:238102	74/132 (56%)
		TUDOR	677..799	CDD:278965	61/122 (50%)
		TUDOR	728..784	CDD:197660	28/56 (50%)
		SNc	<844..895	CDD:294094	20/50 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158985
Domainoid	1	1.000	131	1.000	Domainoid score	I5137
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8665
Inparanoid	1	1.050	848	1.000	Inparanoid score	I439
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53811
OrthoDB	1	1.010	-	-		D211699at33208
OrthoFinder	1	1.000	-	-		FOG0004476
OrthoInspector	1	1.000	-	-		oto91527
orthoMCL	1	0.900	-	-		OOG6_102097
Panther	1	1.100	-	-	LDO	PTHR12302
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3762
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770