DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and TDRD7

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_055105.2	Gene:	TDRD7 / 23424	HGNCID:	30831	Length:	1098	Species:	Homo sapiens

Alignment Length:	828	Identity:	160/828 - (19%)
Similarity:	265/828 - (32%)	Gaps:	279/828 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 GVKLDADGKPDLSVKVPFADEARYYVETRL---------LQRDVEIRLESVNNSNFIGTILYPKG 287
            |||.||:..|             |.:.|.|         :||.|.:   |.||.      ..||.
Human   151 GVKPDAEMSP-------------YMLHTTLGNEAFKDIPVQRHVTM---STNNR------FSPKA 193

  Fly   288 NIAESLLREGLAKCVDWSMAVMKTGTDKLRAAERFAKEKRLRQWQDYQAKTPA-FNSKEKDFSGT 351
            ::...|           .|.:.:|.|.::........||.       ..|.|| :..|..:....
Human   194 SLQPPL-----------QMHLSRTSTKEMSDNLNQTVEKP-------NVKPPASYTYKMDEVQNR 240

  Fly   352 VVEVFNGDAINVRLSNGQVKKVFFSSIRPPRDQRAVVGTDGEE-------------IVKAPPRGK 403
            :.|:.|      :.:||    ::.|.:  |...:.:...|..:             .|:.|..|.
Human   241 IKEILN------KHNNG----IWISKL--PHFYKELYKEDLNQGILQQFEHWPHICTVEKPCSGG 293

  Fly   404 NYRPLYEIPHMFDAREFLRKKLINKKVQCNLDYISP---PRENFPEKYCYTVSIGG--QNVAEAM 463
            ....||....    ::.||.:|..:||.     :||   |::..|.|.|.||..|.  :.||:.:
Human   294 QDLLLYPAKR----KQLLRSELDTEKVP-----LSPLPGPKQTPPLKGCPTVMAGDFKEKVADLL 349

  Fly   464 V---------------------------AKGLAT----C-VRYRQDDDQRSSAYDQLIAAEQQAI 496
            |                           .|.||:    | :.|...:.|::..|.:|.....:..
Human   350 VKYTSGLWASALPKAFEEMYKVKFPEDALKNLASLSDVCSIDYISGNPQKAILYAKLPLPTDKIQ 414

  Fly   497 KGLKGLHAKKD------------------NATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEF 543
            |.....|...|                  :|...:.|:||....|..:..||       ..:||.
Human   415 KDAGQAHGDNDIKAMVEQEYLQVEESIAESANTFMEDITVPPLMIPTEASPS-------VLVVEL 472

  Fly   544 VASGSRLRIFVPKDSCLVTFLLAG-ISCPRSSRPALNGVPA-QEGEPFGDEALTFTRERVLQRDV 606
            ..:...:..:|.||......|:.. :....|..|.:..|.| ..|:..   |:....:..|:..|
Human   473 SNTNEVVIRYVGKDYSAAQELMEDEMKEYYSKNPKITPVQAVNVGQLL---AVNAEEDAWLRAQV 534

  Fly   607 SVHIDTTDKAGSSVIGWLWTDSGANLSVALVEEGLAEVHFSAEKSEYYR------QLKIAEDRAK 665
               |.|.:.               .:.|..|:.|.:|   :.|||:.|:      .|.....:.|
Human   535 ---ISTEEN---------------KIKVCYVDYGFSE---NVEKSKAYKLNPKFCSLSFQATKCK 578

  Fly   666 AAKKNIWTN------YVEEVPKEKTVTEE--EKED----------------------KVVAERKV 700
            .|...:.::      .||.:...|....|  :|.|                      |.:.::.:
Human   579 LAGLEVLSDDPDLVKVVESLTCGKIFAVEILDKADIPLVVLYDTSGEDDININATCLKAICDKSL 643

  Fly   701 N--------YENVIVTEITETLTFFAQSVESG-SKLESLMSKLHADFQSNPPIAGSYT--PKRGD 754
            .        |.||.||.|....|.:.|....| :||..|:.|:...|......:..:.  |..|.
Human   644 EVHLQVDAMYTNVKVTNICSDGTLYCQVPCKGLNKLSDLLRKIEDYFHCKHMTSECFVSLPFCGK 708

  Fly   755 LVAAQFTLDNQWYRAKVERVQGSNA-TVLYIDYGNKETLPTNRLAALPPAFSSE----KPYATEY 814
            :  ..|....:|.|.::..|..|.| .|.::|.|...::..:.|..:||.|..|    .|.|.:.
Human   709 I--CLFHCKGKWLRVEITNVHSSRALDVQFLDSGTVTSVKVSELREIPPRFLQEMIAIPPQAIKC 771

  Fly   815 ALALVALPTDNEDKEEALRAFSED--------VLNHKVQLNVELKVTGSPNLATLRDPTTKVDFG 871
            .||         |..:::..::.|        |||..   :..:||             ||||
Human   772 CLA---------DLPQSIGMWTPDAVLWLRDSVLNCS---DCSIKV-------------TKVD-- 809

  Fly   872 KQLVAEGLVLAEQRGERKL-----KELVDQYKAAQEAARVAHLAIWKY 914
                       |.||...:     |...|.:::...  ::.:..:||:
Human   810 -----------ETRGIAHVYLFTPKNFPDPHRSINR--QITNADLWKH 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615
		SNc	195..333	CDD:214615	23/109 (21%)
		SNc	346..504	CDD:320778	38/207 (18%)
		SNc	538..672	CDD:214615	27/141 (19%)
		TUDOR	697..817	CDD:306940	32/135 (24%)
		SNc	767..914	CDD:320778	33/164 (20%)
TDRD7	NP_055105.2	LOTUS_1_TDRD7	4..91	CDD:193600
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..156		3/4 (75%)
		LOTUS_2_TDRD7	234..300	CDD:193587	11/77 (14%)
		LOTUS_3_TDRD7	338..404	CDD:193588	10/65 (15%)
		TUDOR	459..581	CDD:278965	29/152 (19%)
		TUDOR	517..559	CDD:119391	12/65 (18%)
		TUDOR	648..775	CDD:278965	34/137 (25%)
		TUDOR	707..752	CDD:119391	11/46 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..874
		Interaction with CDK17. /evidence=ECO:0000250	861..1098
		Interaction with CABLES1. /evidence=ECO:0000250	893..1098
		TUDOR	909..1026	CDD:278965
		TUDOR	963..1007	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900