DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and TDRD6

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001010870.1	Gene:	TDRD6 / 221400	HGNCID:	21339	Length:	2096	Species:	Homo sapiens

Alignment Length:	960	Identity:	177/960 - (18%)
Similarity:	317/960 - (33%)	Gaps:	332/960 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 WAWESREFLRKKLIGVE-VTFTFDKPANSNREYGFVWIGKDKETGENVVESIVREG--------- 133
            |:.|:..|.:|.::..| |....||   .:.:| .:.|..:..|||..:..::.:.
Human   612 WSQEAVSFFKKTVLHKELVIHILDK---QDHQY-VIEILDESRTGEENISKVIAQAGYAKYQEFE 672

  Fly   134 -----LVSVRREGRPTAEQQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLVD--- 190
                 ||:....|..:....|   ..::...|..|:....|...:|..::..:      |.|
Human   673 TKENILVNAHSPGHVSNHFTT---ESNKIPFAKTGEGEQKAKRENKTTSVSKA------LSDTTV 728

  Fly   191 IYGGNPVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGVKLDADGKPDLSVKVPFADEARY 255
            :..|:....:.|.|:..|.          |..||.:   |..:|..:..|.:|.|
Human   729 VTNGSTELVVQEKVKRASV----------YFPLMQN---CLEIKPGSSSKGELEV---------- 770

  Fly   256 YVETRLLQRDVEIRLESVNNSNF---------------IGTILYPKGNIAESLLREGLAKCVDWS 305
                   ...||:|:..|.|..:               :..|.|...|.|....|..|| |:
Human   771 -------GSTVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDIQYYCKNTAAPHQRNTLA-CL--- 824

  Fly   306 MAVMKTGTDKLRAAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQV 370
                             ||....|||.  :|......|.|   ...|..|..||...|     .|
Human   825 -----------------AKRTVNRQWS--RALISGIQSVE---HVNVTFVDYGDREMV-----SV 862

  Fly   371 KKVFFSSIRPPRDQRAVVGTDGEEIVKAPPRGKNYR--------PLYEIPHMFDAR------EFL 421
            |.::..|               ||.:|.  :.:.:|        |:.:.|.::|.:      ||:
Human   863 KNIYSIS---------------EEFLKV--KAQAFRCSLYNLIQPVGQNPFVWDVKAIQAFNEFI 910

  Fly   422 ----RKKL-----------INKKVQCNLDYISP---------------------PRENFPEKYCY 450
                :|.|           ||:::...:|.::|                     |.|:..:.:.|
Human   911 DNAWQKNLELKCTIFALASINEELFNIVDLLTPFQSACHFLVEKRLARPVKLQKPLESSVQLHSY 975

  Fly   451 TVSIGGQNVAEAMVAKGLATCVRYRQDDD---------QRSSAYDQLIAAEQQAIKGLKGLHAKK 506
            ..|.....:       |....|.....||         :.::..:||..:..|..|.|..|....
Human   976 FYSTHDMKI-------GSEELVYITHIDDPWTFYCQLARNANILEQLSCSITQLSKVLLNLKTSP 1033

  Fly   507 DN-ATLRVNDLTVDHSRIKVQYLPSWQRALRTEA------IVEF-----VASGSRLRIFVPKDSC 559
            .| .||.:...|..          :|.|.:..|.      .|:|     |.|...|.|  |.|:.
Human  1034 LNPGTLCLAKYTDG----------NWYRGIVIEKEPKKVFFVDFGNIYVVTSDDLLPI--PSDAY 1086

  Fly   560 LVTFL-LAGISCPRSSRPALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGW 623
            .|..| :..:.|..|..|  :.:|        :|.:.:.:|.:|.:.:...:...|..|:.:|.
Human  1087 DVLLLPMQAVRCSLSDIP--DHIP--------EEVVVWFQETILDKSLKALVVAKDPDGTLIIE- 1140

  Fly   624 LWTDS--------------------------------------GANLSVALVE------------ 638
            |:.|:                                      ..|:.:...|
Human  1141 LYGDNIQISASINKKLGLLSYKDRIRKKESEVLCSTTETLEEKNENMKLPCTEYLSKSVGYKLPN 1205

  Fly   639 EGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKT----VTEEEKE-------- 691
            :.:.|..:..:.:..|::||:.:   ...|.|:.|.|.:.|..:.:    :|.|:||
Human  1206 KEILEESYKPQINSSYKELKLLQ---SLTKTNLVTQYQDSVGNKNSQVFPLTTEKKEEISAETPL 1267

  Fly   692 -----DKVVAERKVN-----------------------YENVIVTEITETLTFFAQSVESGSKLE 728
                 :..::|||:.                       ...|.|:.|.:...|:.|.:|..:::.
Human  1268 KTARVEATLSERKIGDSCDKDLPLKFCEFPQKTIMPGFKTTVYVSHINDLSDFYVQLIEDEAEIS 1332

  Fly   729 SLMSKLHA-----DFQSNPPIAGSYTPKRGDLVAAQFTLDNQWYRAKVERVQGSN-ATVLYIDYG 787
            .|..:|::     ::...||:      :|||::.|.|..||.||||.::..|.:: .:|.:||||
Human  1333 HLSERLNSVKTRPEYYVGPPL------QRGDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYG 1391

  Fly   788 NKETLPTNRLAALPPAFSSEKPYATEYALALVALPTDNEDKEEALRAFSE 837
            |...:.||::..|....:.........:|....:| ||::.::.:..||:
Human  1392 NVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVP-DNKNSKKMMHYFSQ 1440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	19/101 (19%)
		SNc	195..333	CDD:214615	29/152 (19%)
		SNc	346..504	CDD:320778	37/216 (17%)
		SNc	538..672	CDD:214615	31/195 (16%)
		TUDOR	697..817	CDD:306940	34/148 (23%)
		SNc	767..914	CDD:320778	19/72 (26%)
TDRD6	NP_001010870.1	TUDOR	<69..133	CDD:278965
		TUDOR	246..380	CDD:278965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..316
		TUDOR	314..360	CDD:119391
		TUDOR	483..604	CDD:278965
		TUDOR	541..585	CDD:119391
		TUDOR	770..886	CDD:278965	34/180 (19%)
		TUDOR	821..866	CDD:119391	18/75 (24%)
		TUDOR	982..1102	CDD:278965	28/138 (20%)
		TUDOR	1037..1080	CDD:119391	10/52 (19%)
		TUDOR	1301..1422	CDD:278965	32/126 (25%)
		TUDOR	1356..1401	CDD:119391	19/44 (43%)
		TUDOR	1516..1638	CDD:278965
		TUDOR	1571..>1609	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900