Protein Alignment Tudor-SN and Tdrd5

DIOPT Version :10

• Sequence 1: NP_612021.1
• Gene: Tudor-SN / 38045
• FlyBaseID: FBgn0035121
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001128213.1
• Gene: Tdrd5 / 214575
• MGIID: 2684949
• Length: 1040
• Species: Mus musculus
• Alignment Length: 750
• Identity: 140/750 - (18%)
• Similarity: 238/750 - (31%)
• Gaps: 252/750 - (33%)

  Fly   197 VKAIIEHVRDGST----VRAFLLPDFHYITLMISGIR---------------CPGVKLDADGKPD 242
            :::::...:||.|    .:.:||...:::.|.|.|.|               |||    .||...
Mouse    15 IRSLLISTKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVSVCPG----GDGTVI 75

  Fly   243 LSVKVPFADEARYYVETRLLQRDVEIRLESVNNSNFIGTILYPKGN------------------- 288
            |.. :|  ||:...:.:.:.:   :.|...|.||       .|||.
Mouse    76 LKA-IP--DESTKGIASLVAK---QRRSHKVRNS-------MPKGRPSICSGRVPYRGRVPPILP 127

  Fly   289 -IAESLLREGLA-----------------------------------KCVDWSMAVMKTGTDKLR 317
             :.:|.|::.||                                   ......::|.:|....|.
Mouse   128 AVVKSELKDLLALSPVLLSDFEKAFARRFGRSFQYMQYGFLSMFEVLNAASDVISVEQTRAGSLL 192

  Fly   318 AAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFF----SSI 378
            ..::...|.:.|.|...:..|..|..|::....|               ...|.|..|    |::
Mouse   193 TLKKSVSEDKQRGWPAGKVFTQPFRMKQQGSYST---------------GFPVMKAHFSQPISNM 242

  Fly   379 RPPRDQRAVVGTDGEEIVKAPPRGKNYRPLYEIPHMFDAREFLRKKLINKKVQCNLDYISPPREN 443
            .||:...::..|.....|:| .|..:...|.::...|       |.:|.:        |.|....
Mouse   243 EPPKQVLSMAKTPTFNSVEA-SRLNHTEKLNQLESTF-------KSVIAQ--------IGPGGTV 291

  Fly   444 FPE---KYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKGLKGLHAK 505
            .||   |..:.||...|.:   .::|.|...               :|...||.:.|.|..|
Mouse   292 DPELKRKIQFVVSKFPQGL---FISKLLGEF---------------ELTFKEQLSPKQLGFL--- 335

  Fly   506 KDNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLV--------- 561
              |.|..|..|:   ..::|::....|..|..:|.::.:.||..|...  ::||||
Mouse   336 --NVTELVGALS---DILRVEFSEERQDLLVFDADLKPLPSGGPLSSV--RNSCLVQPDKKTEAN 393

  Fly   562 --TFLLAGISCPRSSRPALNGVPAQ----------EGEPFGDEALTFTRERVLQRDVSVHIDTTD 614
              |..|        ||.:|:.|..:          :.||   |...:.:..::.:.:.:.::|..
Mouse   394 PWTSSL--------SRNSLSTVAVKKTTWDCPLKNQKEP---EQKIYKKPNLVVKPLQLQVETNK 447

  Fly   615 KAGSSVIGWLWTDSGANLSVALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEV 679
            ..             .:||||                    ...|..|..:|.|       :..:
Mouse   448 PQ-------------LSLSVA--------------------NHDIPPDAVRAKK-------LCRL 472

  Fly   680 PKEKTVTEEEKEDKVVAERKVNYENVIVTEITETLTFFAQ--SVESGSKLESLMSKLHADFQ--- 739
            |...|.|               ...|.|..|.....|:.:  |.:|...||.:|.::...:.
Mouse   473 PPLDTST---------------LVGVFVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQL 522

  Fly   740 -SNPPIAGSYTPKRGDLVAAQFTLDNQWYRAKVERVQG-SNATVLYIDYGNKETLPTNRLAALPP 802
             |:..|...|..:.|.|...:.:.|..|||..:.|:.| ....|.|.|:||..|:..:.|..|..
Mouse   523 VSDRYIMPEYFIQPGHLCCVKISEDKWWYRVIIHRILGKKEVEVFYPDFGNIGTVQKSSLRFLKC 587

  Fly   803 AFSSEKPYATEYALALVALPTDNEDKEEALRAFSE 837
            .::.....|...:||.|. |.:......|:..|.:
Mouse   588 CYTKLPAQAIPCSLAWVR-PAEEHWTARAILHFQK 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_612021.1	SNc	23..166	CDD:214615
		SNc	195..333	CDD:214615	35/209 (17%)
		SNc	346..504	CDD:469627	31/164 (19%)
		SNc	538..672	CDD:214615	26/154 (17%)
		Tudor_TDRD11	723..805	CDD:410504	23/86 (27%)
		YncB	<868..926	CDD:441134
Tdrd5	NP_001128213.1	LOTUS_1_TDRD5	4..98	CDD:193599	19/92 (21%)
		LOTUS_2_TDRD5	127..196	CDD:193589	7/68 (10%)
		LOTUS_3_TDRD5	292..365	CDD:193590	21/98 (21%)
		Tudor_TDRD5	484..601	CDD:410490	28/116 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	912..975