DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and Tdrd6

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001154838.1	Gene:	Tdrd6 / 210510	MGIID:	2679727	Length:	2135	Species:	Mus musculus

Alignment Length:	954	Identity:	186/954 - (19%)
Similarity:	333/954 - (34%)	Gaps:	293/954 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GLVSVRREGRPTAEQQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLVDIYGG--- 194
            |||..||      |:...:..|.|..||.||.|:...::|           :|..|..:..|
Mouse    34 GLVGQRR------EEYVRLSREIQEAAATRGPWALGGASA-----------SPGELCLVQVGLMW 81

  Fly   195 NPVKAIIEHVRDGSTVRAFLLPDFHYIT----------------------LMISGIRCPGVKLDA 237
            :..:.:....:|.   |.|||.:...||                      .:::|:...|.....
Mouse    82 HRCRVVSRQAQDS---RVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGGGGTG 143

  Fly   238 DGKP--------DLSVKVPFADEARYYVETRLLQRDVEIRLESVNNS-NFIGTILYPKGNIAESL 293
            .|:|        |....:...:.....::..||.|.|.:.:..|:.. ..:|.......::..||
Mouse   144 GGEPQQWSPRAVDFLSNLQGKEVHGRVLDVLLLHRLVLLEVPVVSQQMEELGLARQVPDSLFCSL 208

  Fly   294 LREGLAKCVDWSMAVMKTGTDKL-RAAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVV--EV 355
            |:..|......|     :|...| |||.:          |::......:...:...:..||  :|
Mouse   209 LKRYLTAAGQGS-----SGAPVLPRAAPK----------QEHPGLDYFYPQLQLGVTEPVVVTQV 258

  Fly   356 FNGDAINVRLSNGQVKKVFFSSIRPPRDQRAVVGTDG--------EEIVKAPPR----------- 401
            .:...|:.:| ....:::...|....:..||.||||.        ||..::|.:
Mouse   259 CHPHRIHCQL-RSLSQEIHRLSESMAQVYRAPVGTDDEDSGSATWEEREESPDKPGSPCASCGLD 322

  Fly   402 GKNYRPLY----------EIPHMFDAREFLRKKLINKKVQC-NLDYISP-----PRENFP----- 445
            |:.||.|.          ::.|:    ::.||:|    |.| :|.|:.|     |...:|
Mouse   323 GQWYRALLLETFRPQRCAQVLHV----DYGRKEL----VSCSSLRYLLPEYFRMPVVTYPCALYG 379

  Fly   446 -----------------------------EKYC-----YTVSIGGQNVAEAMVAKGLATCV---- 472
                                         |.||     |.|::.|::......|.|:.:|.
Mouse   380 LWDCGRGWSRSQVGDLKALILGQAVNAKIEFYCSFEHMYYVTLYGEDGINLNSAFGVQSCCLADW 444

  Fly   473 ---------RYRQDDDQRSSAY-DQLIAAEQQAIKGLKGLHAKKDNATLRVNDLTVDHSRIKVQY 527
                     ...:|:|:..:|: .|..|.|.:|...|..|.:.:    |::|  |...::::...
Mouse   445 FLQSQGIEEEEEEDEDEVEAAFQSQSPAEEMEAEVSLPSLRSIR----LKMN--TFYDAQVEFVK 503

  Fly   528 LPS--WQRALR--------TEAIVEFVASGSRLRIFV----PKDSCLV----------------- 561
            .||  |.|..:        |:.:..|.:|.|:|...:    |.|.|.|
Mouse   504 SPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVTRLDS 568

  Fly   562 ----TFLL-AGIS-----CP-RSSRPALNGVPAQE-----------GEPFGDEALTFTRERVLQR 604
                .||: .|.|     |. |...|....:|...           |:.:..||.:|.::.||.:
Mouse   569 KSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEATSFFKKTVLHK 633

  Fly   605 DVSVHIDTTDKAGSSVIGWLWTDS---GANLSVALVEEGLAEV---------------------H 645
            ::.||:  .||.....:..:..:|   ..|:|..:.:.|.|:.                     |
Mouse   634 ELVVHV--LDKQDHQYVIEILDESRMGEENISKVIAQAGFAKFQEFETKENIRLSAHSPGHVSGH 696

  Fly   646 FSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKE----KTVTEEEKEDKVVAERKVNYENVI 706
            |.||.|:.....|...|  :.|||:..|..|.|...:    ..::..:..:||.::..:...|.:
Mouse   697 FMAEPSKITSAKKAEGD--QRAKKDNKTLSVSEALADTVSLSNLSTAQDTEKVTSDPSLLMLNFL 759

  Fly   707 VT----------EITETL-----------TFFAQSVESGSKLESLMSKLHADFQSNPPIAGSYTP 750
            .|          |:..|:           :|:.|.:.:.....:||..:....:|:.|     :|
Mouse   760 KTKPDCCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEP-----SP 819

  Fly   751 KRGD--LVAAQFTLDNQWYRAKVERVQG-SNATVLYIDYGNKETLPTNRLAALPPAFSSEKPYAT 812
            ..||  :..|:.|...:|.||.:..... .:..|:::|||:::.:.|..:.::...|...:..|.
Mouse   820 YEGDTRVCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAF 884

  Fly   813 EYALALVALPTDNED---KEEALRAFSEDVLNHKVQLNVELKVT 853
            ..:|..:..|.....   .|:|::||| ..::...|.|:|||.|
Mouse   885 RCSLYNLIQPMGENPFVWDEKAVQAFS-GFIDSARQNNLELKCT 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	12/32 (38%)
		SNc	195..333	CDD:214615	28/169 (17%)
		SNc	346..504	CDD:320778	48/247 (19%)
		SNc	538..672	CDD:214615	41/200 (21%)
		TUDOR	697..817	CDD:306940	25/143 (17%)
		SNc	767..914	CDD:320778	22/91 (24%)
Tdrd6	NP_001154838.1	TUDOR	10..133	CDD:278965	24/118 (20%)
		TUDOR	245..379	CDD:278965	30/142 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..315		9/27 (33%)
		TUDOR	313..359	CDD:119391	10/53 (19%)
		TUDOR	489..610	CDD:278965	24/122 (20%)
		TUDOR	547..591	CDD:119391	8/43 (19%)
		TUDOR	773..890	CDD:278965	23/121 (19%)
		TUDOR	826..869	CDD:119391	10/42 (24%)
		TUDOR	987..1106	CDD:278965
		TUDOR	1042..1084	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1296
		TUDOR	1309..1428	CDD:278965
		TUDOR	1362..1406	CDD:119391
		TUDOR	1519..1641	CDD:278965
		TUDOR	1574..1621	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1699..1733
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1860..1885
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1930..1987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900