DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and Tdrd7

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001277404.1	Gene:	Tdrd7 / 100121	MGIID:	2140279	Length:	1119	Species:	Mus musculus

Alignment Length:	747	Identity:	146/747 - (19%)
Similarity:	244/747 - (32%)	Gaps:	228/747 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 GVKLDADGKPDLSVKVPFADEARYYVETRLLQRDVEIRLESVNNSNFIGTILYPKGNIAESL--- 293
            |||.|.|..|              |.:|. :||...:..    ||.|     .||.::..|.
Mouse   184 GVKADVDMPP--------------YPDTP-VQRHASMSA----NSRF-----SPKSSLPASFQTH 224

  Fly   294 --------LREGLAKCVDW-SMAVMKTGTDKLRAAERFAKEKRLRQWQD------YQAKTPAFNS 343
                    :.:.|.:.|:. ::....:.|:|:...     :.|:::..|      :.:|.|.|..
Mouse   225 ISRACPTEVNDNLNQTVEKPNITPPASYTNKMDEV-----QNRIKEILDKHNNGIWISKLPHFYK 284

  Fly   344 K--EKDFSGTVVEVFNG----DAINVRLSNGQVKKVFFSSIRPP--RDQRAVVGTDGEEIVKAPP 400
            :  ::|.:..|::.|..    ..:......||      .|:..|  |:|......|.|:.:..||
Mouse   285 EFYKEDLNQGVLQQFEHWPHICTVEKPCGGGQ------DSLLYPARREQPLKSDQDPEKELPPPP 343

  Fly   401 RGKNYRPLYEIPH------MFDAREFLRKKLINKKVQCNLDYISPPRE-------NFPE------ 446
            ..    |..|:|.      |.|.:|.:.:.|  .|....|...:.|:.       .|||
Mouse   344 PA----PKQEVPSQGSPAVMPDVKEKVAELL--GKYSSGLWASALPKAFEDMYKVKFPEDALKNL 402

  Fly   447 ----KYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKGLKGLHAKKD 507
                ..|....|.|......:.||......:..:|:.|....:|.....||:.::..|.:....|
Mouse   403 ASLSDVCTINYISGNTQKAILYAKLPLPTDKILKDEGQAQGDFDIKSMIEQEYLQIEKNMAESAD 467

  Fly   508 NATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGISCPR 572
            ..   :.|:||....|..:..||       ..:||...:...:..:|.||......|:.
Mouse   468 EF---LEDITVPPLVIPTEASPS-------VLVVELSNTNDVVIRYVGKDYSAAQELME------ 516

  Fly   573 SSRPALNGVPAQEGEPFGDEALTF----TRERVLQRDVSVHIDTTDKAGSSVIGWL-----WTDS 628
                              ||...|    .|...:|   :||:.......:....||     .||.
Mouse   517 ------------------DEMKEFYSKNPRVTPIQ---TVHVGQLLAVNAEEDAWLRAQIISTDE 560

  Fly   629 GANLSVALVEEGLAEVHFSAEKSEYYR------QLKIAEDRAKAAKKNIWTNYVEEVPKEKTVT- 686
            . .:.|..|:.|..|   :.|||:.||      .|.....:.|.|...:..:..:.|...:::|
Mouse   561 N-KIKVCYVDYGFCE---NIEKSKAYRLNPRFCSLSFQATKCKLAGLEVLNDDPDLVKAVESLTC 621

  Fly   687 --------------------EEEKED---------KVVAERKVN--------YENVIVTEITETL 714
                                :...||         |.:.:|.:.        |.||.||.|....
Mouse   622 GKIFAVEILDKSDVPLVVLYDTSGEDDININATCLKAICDRSLQVHLQVDAMYTNVKVTNICSDG 686

  Fly   715 TFFAQSVESG-SKLESLMSK---------LHADFQSNPPIAGSYTPKRGDLVAAQFTLDNQWYRA 769
            |.:.|....| :||..|:.|         :.:::..:.|..|.         ...|....:|.|.
Mouse   687 TLYCQVPCKGLNKLNDLLHKTEDYFHCKHMTSEYFISLPFCGK---------ICLFHCKGKWLRV 742

  Fly   770 KVERVQGSNA-TVLYIDYGNKETLPTNRLAALPPAFSSE----KPYATEYALALVALPTDNEDKE 829
            ::..|..|.| .|.::|.||..::..:.|..:||.|..|    .|.|.:..||         |..
Mouse   743 EITNVHSSRALDVQFLDSGNSTSVKVSELREIPPRFLQEMLAIPPQAIKCCLA---------DLP 798

  Fly   830 EALRAFSED--------VLNHKVQLNVELKVT 853
            :::..::.|        |||..   :..:|||
Mouse   799 QSIGMWTPDAVLWLRDSVLNCS---DCSIKVT 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615
		SNc	195..333	CDD:214615	21/112 (19%)
		SNc	346..504	CDD:320778	37/186 (20%)
		SNc	538..672	CDD:214615	29/148 (20%)
		TUDOR	697..817	CDD:306940	33/142 (23%)
		SNc	767..914	CDD:320778	25/100 (25%)
Tdrd7	NP_001277404.1	LOTUS_1_TDRD7	38..124	CDD:193600
		LOTUS_2_TDRD7	256..322	CDD:193587	11/76 (14%)
		LOTUS_3_TDRD7	361..425	CDD:193588	12/65 (18%)
		TUDOR	480..602	CDD:278965	31/159 (19%)
		TUDOR	538..580	CDD:119391	10/45 (22%)
		TUDOR	669..796	CDD:278965	34/144 (24%)
		TUDOR	728..773	CDD:119391	12/53 (23%)
		TUDOR	932..1047	CDD:278965
		TUDOR	984..1028	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900