DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tudor-SN and tdrd7b

DIOPT Version :9

Sequence 1:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001340858.1	Gene:	tdrd7b / 100004703	ZFINID:	ZDB-GENE-150109-14	Length:	1085	Species:	Danio rerio

Alignment Length:	745	Identity:	143/745 - (19%)
Similarity:	254/745 - (34%)	Gaps:	218/745 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 KPDLSVKVPFADEARYYVETRLLQRDVEIRLESVNN--SNFIGTILYP---KGNIAESLLREGLA 299
            ||.|....|::.:.            |:.||:.|.|  ||.:.....|   :.:..:.|..|.|.
Zfish   219 KPRLPHSAPYSPKL------------VQSRLQEVLNKHSNGLWVSKLPQLYREHYKQDLPSEALK 271

  Fly   300 KCVDWS--MAVMKTGTDKLRAAERF-AKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAI 361
            :..:|:  ..|.|..:.|.:....: |||...........::|:.:.|.:.         ...::
Zfish   272 ELENWTHICTVEKPCSSKPQELLLYPAKETSQITPTPTHDRSPSHHKKPQT---------QRPSL 327

  Fly   362 NVRLSNGQVKKVFFSSIRPPRDQRAVVGTDGEEIVK--------APPRGKNYRPLYEIPHMFDAR 418
            ..:.:..:..|    ::.|...|:.     ||.::|        |.|:      ||:..:.....
Zfish   328 TAKSNTPESPK----ALSPDLKQKL-----GELLLKYSSGLWAHALPK------LYQDTYKCKLP 377

  Fly   419 EFLRKKLINKKVQCNLDYISPPRENFPEKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSS 483
            ||:..:|......|.:||..|                                     |:.:|:.
Zfish   378 EFVLDQLTLLSDICTIDYPVP-------------------------------------DNPKRAI 405

  Fly   484 AYDQLIAAEQQAIKGLKGLHAKKDNATLRVNDLTVDHSRI-KVQYLPSWQRALRTEA------IV 541
            .|.:::..|.:...||.|...|.:.   |::..||....| :|:| ||   .|..:|      |:
Zfish   406 LYAKVVEDENRNQSGLAGQEMKLER---RLSSQTVPPLVIPRVEY-PS---VLVVDASDTNCVIL 463

  Fly   542 EFVASG---------SRLRIFVPKDSCLVTFLLAGISCPRSSRPA-LNGVPAQEGEPFGDEALTF 596
            .::..|         ..:|.|..:|:..:..        ||..|. |..|.|:|    .|:.:..
Zfish   464 RYIGEGYSKAQEKLEDEMREFYRQDNTKMAL--------RSPSPGQLTAVGAEE----EDDIIRA 516

  Fly   597 TRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSGANLSVAL-----VEEGLAEVHFSAEKSEYYRQ 656
            ....|:...|.|:               :.|.|.:..:::     :.|....:.|.|.|.:....
Zfish   517 QVCEVMADKVKVY---------------YVDHGFSEVISIRKLFELNEKFYRLPFQATKCKLAGL 566

  Fly   657 LKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEE--EKED----------------------KVVAE 697
            ...::::|...|       :|.:...|.:..|  |:||                      |.:.:
Zfish   567 ESFSQEQAVLKK-------LESIATGKILLAEILEREDMPLVVLYDTSQDDDVNINAACMKALQD 624

  Fly   698 R------KVN--YENVIVTEITETLTFFAQSVESG-SKLESLMSK----LHADFQSNPPIAGSYT 749
            |      |||  |.||.||.:....|.:.|....| :||..::.|    .|:...|...::   .
Zfish   625 RSLESPLKVNSAYMNVSVTSVCSDGTIYCQVPSRGLTKLNEILEKTENYFHSQVTSESLVS---R 686

  Fly   750 PKRGDLVAAQFTLDNQWYRAKVERVQGSNA-TVLYIDYGNKETLPTNRLAALPPAFSSEKPYATE 813
            |..|....|::  ..:|.|.::..:.||.. .:|::|.|.:.::....|..:||....:......
Zfish   687 PFCGKNCLARY--KGKWSRVEITNLHGSRVLDILFVDVGVQASVEVIELREIPPPLLRDLISTPA 749

  Fly   814 YAL--ALVALPTD----NEDKEEALRAFSEDVLNHKVQLNVEL-KVTGSPNLATLRDPTTK---- 867
            .||  .|..||..    ..|..:.||    |.:.|....:::: ||..:..||.:...|:|
Zfish   750 QALKCCLAGLPVSVGLWTPDAVQWLR----DTVLHISDCSLKIAKVDETKRLAHVYLFTSKNFHD 810

  Fly   868 --VDFGKQLVAEGL------VLAEQRGERK 889
              ....:||....|      |....||..|
Zfish   811 TSCSLNQQLADSDLWNHQKDVFLSSRGPLK 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615
		SNc	195..333	CDD:214615	22/100 (22%)
		SNc	346..504	CDD:320778	24/165 (15%)
		SNc	538..672	CDD:214615	25/154 (16%)
		TUDOR	697..817	CDD:306940	32/135 (24%)
		SNc	767..914	CDD:320778	32/143 (22%)
tdrd7b	NP_001340858.1	LOTUS_1_TDRD7	4..91	CDD:193600
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..183
		Retinal	<160..342	CDD:330657	25/147 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..228		3/8 (38%)
		LabA_like_C	232..297	CDD:326367	15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..341		6/56 (11%)
		LOTUS_3_TDRD7	341..408	CDD:193588	18/114 (16%)
		TUDOR	442..565	CDD:306940	29/153 (19%)
		TUDOR	636..758	CDD:306940	29/126 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	843..888
		TUDOR	897..1013	CDD:306940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900