DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyx and TRPA1

DIOPT Version :9

Sequence 1:NP_612015.1 Gene:pyx / 38037 FlyBaseID:FBgn0035113 Length:956 Species:Drosophila melanogaster
Sequence 2:XP_011515926.1 Gene:TRPA1 / 8989 HGNCID:497 Length:1144 Species:Homo sapiens


Alignment Length:1107 Identity:236/1107 - (21%)
Similarity:402/1107 - (36%) Gaps:317/1107 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 EAHEIFARQQQNQILWDLDEVKETLTESPGGKHVVDMVQSGCFLELMTDSADCNL------ALIC 105
            |..|...|....::|.::|:...|.......|:.::.|:.     |::..|:.||      |.:.
Human   102 ELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKF-----LLSRGANPNLRNFNMMAPLH 161

  Fly   106 CSVFGSVENTL-FLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADP---NRWDARK 166
            .:|.|.....: .||:|...|.|:....|.|.:..||...|:...::||..||.|   |:|..  
Human   162 IAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGC-- 224

  Fly   167 EVTSLHCAASSKSVECILLLLR--------RKASIN-IGIEKRSALHYAIDVNAVDCVEILLKYG 222
              ..:|.||.|.|.||:.::||        |:..|| :...|.:.||.|:....::.:::.|..|
Human   225 --FPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNG 287

  Fly   223 A--DP-----------------------------------NTPQVYTETPLHTASAAGFAKCVQL 250
            |  ||                                   ||.....||.||.||.....:....
Human   288 AQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADY 352

  Fly   251 LLSHNADVRSQFGEGKVTALHLAAENDYVECARLLLEHRAEVDC-----RNASHQ---------- 300
            |:|..||:.....||: :.|.||..:.......|||...|:||.     ||..|.          
Human   353 LISVGADINKIDSEGR-SPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKN 416

  Fly   301 -----------------------TPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVK 342
                                   ||||.||.....|:|:.|:.:..::::..:|.::.||.| ..
Human   417 LRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFA-AS 480

  Fly   343 QSRSLDCCNALLKAGAD---VNKADNYGYTPLHIAALNEFSSCVYTFIEHGA------------- 391
            ..| ::.|..||:..:|   :|:.|.:|.||||:||.|.....|...::.||             
Human   481 YGR-INTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALH 544

  Fly   392 -------------------DITARTD-------------GRVSALSFIVRRTPEII--------- 415
                               ..|.|.|             |...|::.::....:|:         
Human   545 HASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFL 609

  Fly   416 ----------------------------------------------PKLMQKLDSSIKANDQEIG 434
                                                          |:.|:.|......:..|  
Human   610 HLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTE-- 672

  Fly   435 DVDC------------QIKLDFRLLVPSSSMDRGETELLLSLIEVGQKRILMHPLCETFLFLKWR 487
            |..|            |..|:|....|:..:.......|.::::..:..:|.||:|:.:|.:||.
Human   673 DKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWL 737

  Fly   488 RIR-KFFLMSLAYHTLFVILFTFYVIWVYVRCCKKEELCVAPG---------------------- 529
            ... :..:|:|..:.|.:|..|..|:            .:.||                      
Human   738 AYGFRAHMMNLGSYCLGLIPMTILVV------------NIKPGMAFNSTGIINETSDHSEILDTT 790

  Fly   530 ---YVSTIGYLVIILNLILLGKEVFQMAHGLRGYAKYWENWLQWTIGTGVLLCVTPETVRTDDLT 591
               .:.|...||.:.::....||..|:....|.|.....|.|:|.|.|..::.|.|..|   ::.
Human   791 NSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFV---EIP 852

  Fly   592 AVPVWQHHVAAIVILLVWLELMMLVGRFPIFGVYVQMFTKVAVNFAKFLLAYICLLVAFGLSFAV 656
            |...||  ..||.:...|:..::.:.||...|:::.|...:.....:..:.:|.||:||||||.:
Human   853 AHLQWQ--CGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYI 915

  Fly   657 LFNDYPAFENITWSFLKSITMMSGELEFEDIFYGDY---AVKFPVTAHIIFLSFVLLVTVILTNL 718
            |.|....|.:...|.:::.:||.|::.:.:.|...|   .:..||.:....:||.:.|.::|.||
Human   916 LLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNL 980

  Fly   719 MVGLAVSDIQGLQVSATLDRLVRQAELVSRLES---LFFSRLLRSAPTNLIQLCKRSALLRTSRD 780
            ::||||.||..:|..|:|.|:..|.||.:.||.   |:|.|.:                     |
Human   981 LIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKV---------------------D 1024

  Fly   781 KLQFTIRPNDPRDNQLPEDIKLNVY---KLVAERRDRNQSLRRRQFENNYNI--FSRSLQRQQQP 840
            :....:.||.||...:...|...::   ::..|..:.::||.....:..|.:  .:..|::|.:.
Human  1025 QKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHEL 1089

  Fly   841 LHTDFLKPEPATGTTKKTPQNLFHMHELLRPRSATNVPQQFRQEAEGTVQMKNQANVLSAVLAEV 905
            :.....|.|..:.|....              |..:...:|::|     ||:.:.:..:.||..|
Human  1090 IKLIIQKMEIISETEDDD--------------SHCSFQDRFKKE-----QMEQRNSRWNTVLRAV 1135

  Fly   906 QA 907
            :|
Human  1136 KA 1137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pyxNP_612015.1 Ank_4 99..153 CDD:290365 15/60 (25%)
ANK repeat 102..130 CDD:293786 8/28 (29%)
ANK 127..252 CDD:238125 42/173 (24%)
ANK repeat 132..163 CDD:293786 11/33 (33%)
Ank_2 137..226 CDD:289560 31/137 (23%)
ANK repeat 166..196 CDD:293786 12/38 (32%)
ANK 198..319 CDD:238125 43/195 (22%)
ANK repeat 200..229 CDD:293786 10/65 (15%)
Ank_2 203..296 CDD:289560 31/134 (23%)
ANK repeat 231..262 CDD:293786 10/30 (33%)
ANK 268..387 CDD:238125 41/159 (26%)
ANK repeat 268..296 CDD:293786 9/32 (28%)
Ank_2 270..364 CDD:289560 31/134 (23%)
ANK repeat 298..329 CDD:293786 10/63 (16%)
ANK repeat 331..364 CDD:293786 10/35 (29%)
Ank_5 353..404 CDD:290568 20/98 (20%)
ANK repeat 366..396 CDD:293786 12/61 (20%)
Ion_trans 556..734 CDD:278921 53/180 (29%)
TRPA1XP_011515926.1 Ank_4 91..143 CDD:290365 8/45 (18%)
ANK repeat 92..120 CDD:293786 4/17 (24%)
ANK 120..243 CDD:238125 35/131 (27%)
ANK repeat 122..153 CDD:293786 7/35 (20%)
Ank_2 127..220 CDD:289560 24/97 (25%)
ANK repeat 155..187 CDD:293786 8/31 (26%)
ANK repeat 189..214 CDD:293786 7/24 (29%)
ANK repeat 222..261 CDD:293786 13/42 (31%)
Ank_4 226..282 CDD:290365 16/55 (29%)
ANK 258..387 CDD:238125 28/129 (22%)
ANK repeat 266..294 CDD:293786 8/27 (30%)
Ank_2 268..364 CDD:289560 20/95 (21%)
ANK repeat 296..364 CDD:293786 12/67 (18%)
ANK 361..527 CDD:238125 43/168 (26%)
ANK repeat 366..397 CDD:293786 11/31 (35%)
ANK repeat 437..468 CDD:293786 9/30 (30%)
Ank_2 442..531 CDD:289560 27/90 (30%)
ANK repeat 470..504 CDD:293786 10/35 (29%)
ANK 501..625 CDD:238125 19/123 (15%)
ANK repeat 506..536 CDD:293786 11/29 (38%)
Ank_2 511..602 CDD:289560 14/90 (16%)
ANK repeat 538..570 CDD:293786 2/31 (6%)
ANK repeat 572..597 CDD:293786 2/24 (8%)
Ion_trans 769..997 CDD:278921 59/232 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D180347at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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