DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyx and AKR2

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_014677.1	Gene:	AKR2 / 854199	SGDID:	S000005560	Length:	749	Species:	Saccharomyces cerevisiae

Alignment Length:	739	Identity:	144/739 - (19%)
Similarity:	267/739 - (36%)	Gaps:	202/739 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LLDKRSISSEANSAGVFSDEAHEIFARQQQNQILWDLDEVKETLTESPGGKHVVDMVQSGCFLEL 92
            ::|..::...:|.|.|.:|.|....:....|:        .:.|.:....::|||:     |:|.
Yeast     6 IIDDENVKKTSNGAAVVTDVAQHAVSDSDNNK--------AQLLGDGSNTEYVVDI-----FIEA 57

  Fly    93 MTDSADCNLALICCSV-FGSVENTLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFG 156
            ..|.   :|.::...| .|:|:        .|.| .:.:..|   ||:||......:||.||..|
Yeast    58 AKDG---DLKVVKDVVESGAVD--------INND-RIDELSG---LHWACINNRFSVAKFLLLRG 107

  Fly   157 ADPNRWDARKEVTSLHCAASSKSVECILLLLRRKASINIGIEKRSALHYAIDVNAVDCVEILLKY 221
            |:||:.......|:||.||             |..:|.|                   |::|||:
Yeast   108 ANPNQAAGPGGATALHWAA-------------RYGNIYI-------------------VDLLLKH 140

  Fly   222 GADPNTPQVYTETPLHTASAAGFAKCVQLLLSHNADVRSQFGEGKVTALHLAAENDYVECARLLL 286
            ||||.   :..|..|:....:.::..:.|:               |..|:....|:
Yeast   141 GADPT---LKDEQGLNIMHFSVYSSNILLV---------------VYVLYFVVNNN--------- 178

  Fly   287 EHRAEVDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVKQSRSLDCCN 351
             ...::|.::.:::|||..|.......||:||:.:|:.|......|..|||.|:|...:.:.|
Yeast   179 -DNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVIC-- 240

  Fly   352 ALLKAGADVNKADNYGYTPLHIA-ALNEFSSCVYTFIEHGADITARTDGRVSALSFIVRRTPEII 415
            .|:.:||:..:.:|.......:| .:...|........||.|.......::...|...:.|..:.
Yeast   241 DLILSGANFYERNNQKQDCFDLAEGMGTKSLFEQALQHHGYDRLGNQKDKLFKKSSHAQFTIFLS 305

  Fly   416 PKLMQKLDSSIKANDQEIGDVDCQIKLDFRLLVPSSSMDRGETELLLSLIEVGQKRILMHP---- 476
            |.|:.                 ..|.|...:|.|..::   ...||::::.|...:..:.|
Yeast   306 PFLLM-----------------VYIYLISLVLSPVLAI---MLSLLVTVVMVNTLKKFVLPCLPR 350

  Fly   477 -----------------LCETFLFLKWRRIRKFFLMSLAYHTLFVILF---TFYVIWVYVRCCKK 521
                             ...||.||.:...:|.:..|::.:|:..:.|   :|..:.:::|..:.
Yeast   351 KNTYKVSLTRTPFFSGLFLSTFCFLIYIWTKKLYPYSVSDYTMKNVQFLVTSFLTVVLFLRLVRS 415

  Fly   522 EELCVAPGYVSTIGYLV----IILNLILLGKEVFQMAHGLRGYAKYWENWLQWTIGTGVLLCVTP 582
            :     ||.:.|...|.    .|..||.|||  |..           ||:           ||
Yeast   416 D-----PGCLKTDDSLTSIQETIKQLIDLGK--FDR-----------ENF-----------CV-- 449

  Fly   583 ETVRTDDLTA---------VPVWQHHVAAIVILLVWLELMMLVGRFPIFGVYVQMFTKVAVNFAK 638
            ||:....|.:         |..:.|:..       |:...:.:....:|     :|..|.|.:..
Yeast   450 ETLERKPLRSKYSFFSGALVARYDHYCP-------WIYNDVGLKNHKLF-----VFFAVTVQYHM 502

  Fly   639 FLLAYICLLVAFGLSFAVLFNDYPAFENITWSFLKSITMMSGELEFEDIFYGDYAVKFPVTAHII 703
            ||..::||  |:......::.....:...  :.||:.|:..|.......|:    :...::.:.|
Yeast   503 FLFMWLCL--AYFKKTNYIYEQVEEYARC--ALLKNETLCKGSNYDPSTFF----LFIWISVNFI 559

  Fly   704 FLSFVLLVTVILTNLMVGLAVSDI 727
            :|..:|:|...  .::.|:...::
Yeast   560 WLGAMLIVQFF--QILKGITTPEL 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365	13/54 (24%)
		ANK repeat	102..130	CDD:293786	5/28 (18%)
		ANK	127..252	CDD:238125	32/124 (26%)
		ANK repeat	132..163	CDD:293786	13/30 (43%)
		Ank_2	137..226	CDD:289560	27/88 (31%)
		ANK repeat	166..196	CDD:293786	7/29 (24%)
		ANK	198..319	CDD:238125	22/120 (18%)
		ANK repeat	200..229	CDD:293786	8/28 (29%)
		Ank_2	203..296	CDD:289560	15/92 (16%)
		ANK repeat	231..262	CDD:293786	3/30 (10%)
		ANK	268..387	CDD:238125	26/119 (22%)
		ANK repeat	268..296	CDD:293786	3/27 (11%)
		Ank_2	270..364	CDD:289560	23/93 (25%)
		ANK repeat	298..329	CDD:293786	10/30 (33%)
		ANK repeat	331..364	CDD:293786	10/32 (31%)
		Ank_5	353..404	CDD:290568	9/51 (18%)
		ANK repeat	366..396	CDD:293786	5/30 (17%)
		Ion_trans	556..734	CDD:278921	29/181 (16%)
AKR2	NP_014677.1	ANKYR	1..195	CDD:223738	58/276 (21%)
		ANK repeat	54..81	CDD:293786	9/38 (24%)
		ANK repeat	83..115	CDD:293786	13/34 (38%)
		ANK repeat	117..148	CDD:293786	16/65 (25%)
		ANK repeat	189..220	CDD:293786	10/30 (33%)
		Ank_4	190..243	CDD:372654	17/54 (31%)
		ANK repeat	222..247	CDD:293786	8/26 (31%)
		COG5273	340..711	CDD:227598	51/295 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24161
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100