DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyx and Asb5

DIOPT Version :9

Sequence 1:NP_612015.1 Gene:pyx / 38037 FlyBaseID:FBgn0035113 Length:956 Species:Drosophila melanogaster
Sequence 2:NP_083845.1 Gene:Asb5 / 76294 MGIID:1923544 Length:329 Species:Mus musculus


Alignment Length:322 Identity:94/322 - (29%)
Similarity:151/322 - (46%) Gaps:31/322 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 LALICCSVFGSVENTLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPNRWDAR 165
            |:|.|..:|  |:.:|.:|.|:..   |..:|          :..|.||............|..|
Mouse    22 LSLFCFKLF--VKISLAILSHFYI---VKGNR----------KEAARIAAEFYGVSQGQGSWADR 71

  Fly   166 KEVTSLHCAASSKSVECILLLLRRKASIN-IGIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQ 229
               :.||.|||...:..:..||.:..::| :.|:..:.||.|...:.|.|...||:.||:.|...
Mouse    72 ---SPLHEAASQGRLLALRTLLSQGYNVNAVTIDHVTPLHEACLGDHVACARTLLEAGANANAIT 133

  Fly   230 VYTETPLHTASAAGFAKCVQLLLSHNADVRSQFGEGKVTALHLAAENDYVECARLLLEHRAEVDC 294
            :...|||..|.:.|.|.|.:|||.:.|  ::|......:..|.||...:.||..:|:....:|| 
Mouse   134 IDGVTPLFNACSQGSASCAELLLEYGA--KAQLESCFPSPTHEAASKGHHECLDILIAWGIDVD- 195

  Fly   295 RNASH-QTPLHLACLSQSIGTVDLLISYGANVN-AVYRDGRTALHAAIVKQSRSLDCCNALLKAG 357
            ::..| .|||::||:||....:..|:..||:|: ..|.|  |.||||  .|..|.:..|.||:.|
Mouse   196 QDIPHLGTPLYVACMSQQFHCIWKLLYAGADVHKGKYWD--TPLHAA--AQQPSTEIVNLLLEFG 256

  Fly   358 ADVNKADNYGYTPLHIAALNEFSSCVYTFIEHGADITARTD-GRVSALSFIVRRTPEIIPKL 418
            ||:|..:.....|:.:|..|  |:.....::|.|..::... .|:...::|.|:...:||:|
Mouse   257 ADINAKNTDLLRPVDLATSN--SAVERILLQHEATPSSLCQLCRLCIRNYIGRQRFHLIPQL 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pyxNP_612015.1 Ank_4 99..153 CDD:290365 13/51 (25%)
ANK repeat 102..130 CDD:293786 8/27 (30%)
ANK 127..252 CDD:238125 34/125 (27%)
ANK repeat 132..163 CDD:293786 4/30 (13%)
Ank_2 137..226 CDD:289560 23/89 (26%)
ANK repeat 166..196 CDD:293786 8/30 (27%)
ANK 198..319 CDD:238125 38/121 (31%)
ANK repeat 200..229 CDD:293786 10/28 (36%)
Ank_2 203..296 CDD:289560 30/92 (33%)
ANK repeat 231..262 CDD:293786 11/30 (37%)
ANK 268..387 CDD:238125 40/120 (33%)
ANK repeat 268..296 CDD:293786 8/27 (30%)
Ank_2 270..364 CDD:289560 36/95 (38%)
ANK repeat 298..329 CDD:293786 12/32 (38%)
ANK repeat 331..364 CDD:293786 15/32 (47%)
Ank_5 353..404 CDD:290568 13/51 (25%)
ANK repeat 366..396 CDD:293786 6/29 (21%)
Ion_trans 556..734 CDD:278921
Asb5NP_083845.1 ANK 1 69..98 8/31 (26%)
ANK repeat 71..100 CDD:293786 9/31 (29%)
Ank_2 73..>289 CDD:393464 72/224 (32%)
ANK repeat 102..133 CDD:293786 10/30 (33%)
ANK 2 102..131 9/28 (32%)
ANK 3 135..164 11/30 (37%)
ANK repeat 135..160 CDD:293786 10/24 (42%)
ANK 4 167..196 8/29 (28%)
ANK repeat 170..198 CDD:293786 8/28 (29%)
ANK repeat 200..230 CDD:293786 12/29 (41%)
ANK 5 200..229 12/28 (43%)
ANK repeat 232..263 CDD:293786 16/34 (47%)
ANK 6 232..261 15/32 (47%)
SOCS_ASB5 288..329 CDD:239694 7/29 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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