DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyx and Asb3

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_076395.2	Gene:	Asb3 / 65257	MGIID:	1929749	Length:	525	Species:	Mus musculus

Alignment Length:	476	Identity:	115/476 - (24%)
Similarity:	175/476 - (36%)	Gaps:	118/476 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 ACCRANAPIAKVLLDFG-----ADPNRWDARKEVTSLHCAASSKSVECILLLLRRKASINI---- 195
            |....|..|.:.||..|     ||...|      ..:|.||...:|||:.:|:...:|.|.
Mouse    17 AAREGNVKILRKLLKKGRSVDVADNRGW------MPIHEAAYHNAVECLQMLIHTDSSENYIKAK 75

  Fly   196 GIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYTETPLHTASAAGFAKCVQLLLSHNADVRS 260
            ..|...|||.|:........:|||:.|||||...:...|||..|..:|....::|||.|.|:|..
Mouse    76 TFEGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNG 140

  Fly   261 QFGEGKVTALHLAAENDYVECARLLLEHRAEVDCRNASHQTPLHLACLSQSIGTVDLLISYGANV 325
            ........:||.|:.....|..||||:..|:.:|::....|||.:|.....:.::.:|||.||||
Mouse   141 SHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANV 205

  Fly   326 NAVYRDGRTALHAAIVKQSRSLDCCNALLKAGADVN---KADNYGYTPLHIAALNEFSSCVYTFI 387
            |....|..|.|.  |..|.....|...||.:|||.:   ..||: ..|:|.||
Mouse   206 NCQALDKATPLF--IAAQEGHTKCVELLLSSGADPDLYCNEDNW-QLPIHAAA------------ 255

  Fly   388 EHGADITARTDGRVSALSFIVRRTPEIIPKLMQKLDSSIKANDQEIGDVDCQIKLDFRLLVPSSS 452
                     ..|....|..::.||           :.:......::..|             .|:
Mouse   256 ---------QMGHTETLDLLIPRT-----------NRACDTGPDKVSPV-------------YSA 287

  Fly   453 MDRGETELLLSLIEVG-----QKRILM---HPLCETF-----------LFLKW-RRIRKFFLMSL 497
            :..|..|.|..|::.|     |..::.   .|||..|           :.||: .::.:..|...
Mouse   288 VFGGREECLEMLLQNGYSPDAQMCLVFGFSSPLCMAFQKDCDFSGIVNILLKYGAQLNELHLAYC 352

  Fly   498 AYHTLFVILFTFYVIWVYVRCCKKEELCVAPGYVSTIGYLVIILNLILLGKEVFQMAHGLRGYAK 562
            ..:..|.:..:|         .||..|.|...:.|..                  :::.::...|
Mouse   353 LKYEKFSMFCSF---------LKKGSLMVPWNHTSEF------------------ISYAVKAQTK 390

  Fly   563 YWENWLQWTIGTG----VLLC 579
            | :.||...:..|    :|||
Mouse   391 Y-KAWLPHLLLAGFDPLILLC 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365	3/12 (25%)
		ANK repeat	102..130	CDD:293786
		ANK	127..252	CDD:238125	37/120 (31%)
		ANK repeat	132..163	CDD:293786	8/27 (30%)
		Ank_2	137..226	CDD:289560	29/94 (31%)
		ANK repeat	166..196	CDD:293786	9/33 (27%)
		ANK	198..319	CDD:238125	38/120 (32%)
		ANK repeat	200..229	CDD:293786	12/28 (43%)
		Ank_2	203..296	CDD:289560	32/92 (35%)
		ANK repeat	231..262	CDD:293786	11/30 (37%)
		ANK	268..387	CDD:238125	39/121 (32%)
		ANK repeat	268..296	CDD:293786	10/27 (37%)
		Ank_2	270..364	CDD:289560	33/96 (34%)
		ANK repeat	298..329	CDD:293786	12/30 (40%)
		ANK repeat	331..364	CDD:293786	11/35 (31%)
		Ank_5	353..404	CDD:290568	12/53 (23%)
		ANK repeat	366..396	CDD:293786	4/29 (14%)
		Ion_trans	556..734	CDD:278921	8/28 (29%)
Asb3	NP_076395.2	ANK 1	9..38		6/20 (30%)
		Ank_2	22..>237	CDD:393464	72/222 (32%)
		ANK repeat	42..76	CDD:293786	10/39 (26%)
		ANK 2	42..71		9/34 (26%)
		ANK repeat	78..109	CDD:293786	13/30 (43%)
		ANK 3	78..107		12/28 (43%)
		ANK repeat	111..142	CDD:293786	11/30 (37%)
		ANK 4	111..140		11/28 (39%)
		ANK repeat	145..176	CDD:293786	10/30 (33%)
		ANK 5	145..174		9/28 (32%)
		ANK repeat	178..209	CDD:293786	12/30 (40%)
		ANK 6	178..207		11/28 (39%)
		ANK repeat	211..240	CDD:293786	11/30 (37%)
		ANK 7	211..240		11/30 (37%)
		Ank_2	216..309	CDD:372319	26/140 (19%)
		ANK repeat	245..309	CDD:293786	17/109 (16%)
		ANK 8	246..275		9/61 (15%)
		ANK 9	279..308		7/41 (17%)
		ANK repeat	314..345	CDD:293786	6/30 (20%)
		ANK 10	315..346		6/30 (20%)
		SOCS_ASB3	458..508	CDD:239692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910