DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyx and asb5a

DIOPT Version :9

Sequence 1:NP_612015.1 Gene:pyx / 38037 FlyBaseID:FBgn0035113 Length:956 Species:Drosophila melanogaster
Sequence 2:XP_005157376.1 Gene:asb5a / 550441 ZFINID:ZDB-GENE-070424-269 Length:331 Species:Danio rerio


Alignment Length:318 Identity:86/318 - (27%)
Similarity:129/318 - (40%) Gaps:66/318 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 LALICCSVFGSVENTLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPNRWDAR 165
            |:|.|..:|  |..||.||.|:..   :..:|          :..|.|:....|.|.....|..|
Zfish    23 LSLFCFKLF--VRITLNLLTHFYI---IKGNR----------KEAARISAEFYDNGQGHGSWADR 72

  Fly   166 KEVTSLHCAASSKSVECILLLLRRKASINI-GIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQ 229
               ::||.|||...:..:..|:.:..|:|: .|:..|.||.|.....|.|...|:..||:.|...
Zfish    73 ---SALHDAASQGRLLALKTLIAQGHSVNVLTIDHISPLHEACIGGHVACARALVDAGANVNVTA 134

  Fly   230 VYTETPLHTASAAGFAKCVQLLLSHNADVRSQ-FGEGKVTALHLAAENDYVECARLLLEHRAEVD 293
            :...|||..|.:||...|::|||  .:|.|.| ....:.:.:|.||...:.:|..:|:....:||
Zfish   135 IDGVTPLFRACSAGSLACLELLL--QSDARPQALAIFQPSPIHEAASRGHSKCVEMLVSWGVDVD 197

  Fly   294 CRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVKQSRSLDCCNALLKAGA 358
            .......|||:.||                                   |.:...|...||..||
Zfish   198 FEIPHMGTPLYTAC-----------------------------------QCKEFLCARKLLDGGA 227

  Fly   359 DVNKADNYGYTPLHIAALNEFSSCVYTFIEHGADITARTDGRVSALSFIVRRTPEIIP 416
            :|.:. :|..||||.|:..:..|.|...:|.|||:.||.      |.:  :|..|:.|
Zfish   228 NVQRG-SYMETPLHAASQKDCLSIVKLLLEFGADVNARN------LQY--KRAVEVAP 276

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pyxNP_612015.1 Ank_4 99..153 CDD:290365 13/51 (25%)
ANK repeat 102..130 CDD:293786 9/27 (33%)
ANK 127..252 CDD:238125 34/125 (27%)
ANK repeat 132..163 CDD:293786 5/30 (17%)
Ank_2 137..226 CDD:289560 24/89 (27%)
ANK repeat 166..196 CDD:293786 8/30 (27%)
ANK 198..319 CDD:238125 35/121 (29%)
ANK repeat 200..229 CDD:293786 10/28 (36%)
Ank_2 203..296 CDD:289560 29/93 (31%)
ANK repeat 231..262 CDD:293786 13/31 (42%)
ANK 268..387 CDD:238125 27/118 (23%)
ANK repeat 268..296 CDD:293786 7/27 (26%)
Ank_2 270..364 CDD:289560 19/93 (20%)
ANK repeat 298..329 CDD:293786 5/30 (17%)
ANK repeat 331..364 CDD:293786 7/32 (22%)
Ank_5 353..404 CDD:290568 19/50 (38%)
ANK repeat 366..396 CDD:293786 12/29 (41%)
Ion_trans 556..734 CDD:278921
asb5aXP_005157376.1 ANK 72..190 CDD:238125 37/122 (30%)
Ank_4 72..124 CDD:290365 16/54 (30%)
ANK repeat 72..101 CDD:293786 9/31 (29%)
ANK repeat 103..134 CDD:293786 10/30 (33%)
Ank_2 108..197 CDD:289560 27/90 (30%)
ANK repeat 136..165 CDD:293786 12/30 (40%)
ANK repeat 169..197 CDD:293786 5/27 (19%)
ANK 172..275 CDD:238125 36/146 (25%)
Ank_2 174..265 CDD:289560 32/126 (25%)
ANK repeat 202..232 CDD:293786 12/64 (19%)
ANK repeat 234..265 CDD:293786 13/30 (43%)
SOCS 290..331 CDD:295349
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
00.000

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