DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyx and ASB1

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001035535.1	Gene:	ASB1 / 51665	HGNCID:	16011	Length:	335	Species:	Homo sapiens

Alignment Length:	188	Identity:	50/188 - (26%)
Similarity:	94/188 - (50%)	Gaps:	29/188 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 TSLHCAASSKSVECILLLLRRKASIN-IGIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYT 232
            |.|..||::....|:..|:|:.|.:: :.::.::||:.|:....::..:|||:.|||||..:.:.
Human    80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHR 144

  Fly   233 ETPLHTASAAGFAKCVQLLLSHNA----------DVRSQFGEGKVTA-----LHLAAENDYVECA 282
            .||::.||..|.|..::.|:.:.|          ||:.:|.. ::|:     |:::|....::|.
Human   145 STPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSR-RLTSLVVCPLYISAAYHNLQCF 208

  Fly   283 RLLLEHRAEVD--CRNASHQTPLHL---ACLSQSI-------GTVDLLISYGANVNAV 328
            ||||...|..|  |....:....:.   .|:..::       ..|.||:.:|||:|.|
Human   209 RLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLV 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365
		ANK repeat	102..130	CDD:293786
		ANK	127..252	CDD:238125	25/83 (30%)
		ANK repeat	132..163	CDD:293786
		Ank_2	137..226	CDD:289560	17/57 (30%)
		ANK repeat	166..196	CDD:293786	8/27 (30%)
		ANK	198..319	CDD:238125	36/147 (24%)
		ANK repeat	200..229	CDD:293786	11/28 (39%)
		Ank_2	203..296	CDD:289560	32/109 (29%)
		ANK repeat	231..262	CDD:293786	10/40 (25%)
		ANK	268..387	CDD:238125	20/78 (26%)
		ANK repeat	268..296	CDD:293786	11/34 (32%)
		Ank_2	270..364	CDD:289560	19/71 (27%)
		ANK repeat	298..329	CDD:293786	9/41 (22%)
		ANK repeat	331..364	CDD:293786
		Ank_5	353..404	CDD:290568
		ANK repeat	366..396	CDD:293786
		Ion_trans	556..734	CDD:278921
ASB1	NP_001035535.1	Ank_2	22..108	CDD:393464	8/27 (30%)
		ANK 1	36..68
		ANK repeat	41..70	CDD:293786
		ANK 2	77..106		8/25 (32%)
		ANK repeat	79..108	CDD:293786	8/27 (30%)
		PHA02875	80..>266	CDD:165206	49/186 (26%)
		Ank_2	82..173	CDD:372319	26/90 (29%)
		ANK repeat	110..141	CDD:293786	11/30 (37%)
		ANK 3	110..139		10/28 (36%)
		ANK repeat	143..172	CDD:293786	8/28 (29%)
		ANK 4	143..172		8/28 (29%)
		ANK repeat	174..219	CDD:293786	12/45 (27%)
		ANK 5	191..220		8/28 (29%)
		ANK 6	235..265		7/29 (24%)
		SOCS_ASB1	294..335	CDD:239690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000