DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyx and wtrw

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_731193.1	Gene:	wtrw / 40931	FlyBaseID:	FBgn0260005	Length:	986	Species:	Drosophila melanogaster

Alignment Length:	976	Identity:	288/976 - (29%)
Similarity:	461/976 - (47%)	Gaps:	181/976 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WNSESDPTADVDL----------LLDKRSISSEANSAGVFSD-----------EAH-EIFARQQQ 57
            ::|..:||:::.:          |:|:  :.|.|....:|.|           ..| |..::.::
  Fly    88 YDSFEEPTSELSVQICNDTLRISLIDQ--MKSAAGRVKLFEDIEQSNVVAEGIRTHFESASKLEK 150

  Fly    58 NQIL--------WDLDEVKETLTESPGGKHVVDMVQSGCFLELMTDSADCNLALICCSVFGSVEN 114
            |...        |||   .|:|.|:....|..|  |:|             ::.:..|.|.....
  Fly   151 NLCYLWAAYLKRWDL---IESLLEAGADLHFCD--QNG-------------ISALHLSAFSGCLA 197

  Fly   115 TLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPNRWDARK---EVTSLHCAAS 176
            ||.||.....:.|: .|:..||||.|.....|..||:|::.|||.:: |..|   |.:.||||..
  Fly   198 TLGLLVAKGLNVNL-QSKCYTPLHCAAFGNAAEAAKLLINNGADISK-DTSKPNCEESLLHCAVR 260

  Fly   177 SKSVECILLLLRRKASIN-IGIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYTETPLHTAS 240
            |.::||:.:.:...|.:| :.....:|:|.|.|:..:.|:|.||      |.|..
  Fly   261 SNALECLQIFIAEGADVNSLKPNGTNAIHLAADLGNIQCLEALL------NAPNA---------- 309

  Fly   241 AAGFAKCVQLLLSHNADVRSQFGEGKVTALHLAAENDYVECARLLLEHRAEVDCRNASHQTPLHL 305
                          :|:||....|.:.|||||||:...|||..|||...|:...:|....|||||
  Fly   310 --------------DANVRICIREKESTALHLAADEGNVECVDLLLAKGADAKLKNHRGFTPLHL 360

  Fly   306 ACLSQSIGTVDLLISYG-ANVNAVYRDGRTALHAAIVKQSRSLDCCNALLKAGADVNKADNYGYT 369
            |..:.|:..|:.|:..| |:.||...|.||.||||:.|...:.|....|::.||:||..|.||:|
  Fly   361 AARTSSLDCVESLLRNGNADANAEDFDHRTPLHAAVGKSENAYDIMETLIQWGANVNHKDIYGFT 425

  Fly   370 PLHIAALNEFSSCVYTFIEHGADITARTDGRVSALSFIVRRTPEIIPKLMQKLDSSIKA-NDQEI 433
            .||:|||:....||...|.||||:|.::....|||:.|.|:||..:..:.||||::|.. :.|:.
  Fly   426 ALHLAALDGLVQCVEMLIFHGADVTTKSKKGTSALNVITRKTPASVAMIRQKLDAAITLHHSQDP 490

  Fly   434 GDVDCQIKLDFRLLVPSSSMDRGETELLLSLIEVGQKRILMHPLCETFLFLKWRRIRKFFLMSLA 498
            .:.:.:::||||.|:  ......|...|.:.::.|||.||.||||.:||::||.:|||:::..|.
  Fly   491 VNREVELELDFRQLL--QHCHPREISYLNTFVDEGQKEILEHPLCSSFLYIKWGKIRKYYIGRLI 553

  Fly   499 YHTLFVILFTFYVIWVYVRCC-----------KKEELCVAPG----------YVSTIGYLVIILN 542
            :...||:..|.||:......|           ..:|||....          :|..:.:.|::..
  Fly   554 FCFSFVLFLTLYVLTALAHNCYNGSKNDNTTIPAQELCQKQSILGDMLRNNPFVMEMQWWVLVAI 618

  Fly   543 LILLGKEVFQMAHGLRGYAKY------WENWLQWTIGTGVLLCVTPETVRTDDLTAVPVWQHHVA 601
            .|:   |:|:..:|:.||:.:      .||.::|.:.|.|.:.....|.:|      ..:|:|:.
  Fly   619 TIV---EIFRKLYGITGYSSFRHYVTQVENIMEWFVITSVFVISYIYTNKT------YTFQNHIG 674

  Fly   602 AIVILLVWLELMMLVGRFPIFGVYVQMFTKVAVNFAKFLLAYICLLVAFGLSFAVLFNDYPAFEN 666
            |..:||.|..||:::|:.|:|.|||.|:|:|...|||..:||.|:|:.|.:||.|:|....:|.|
  Fly   675 AFAVLLGWTNLMLMIGQLPVFDVYVAMYTRVQGEFAKLFMAYSCMLIGFTISFCVIFPSSSSFAN 739

  Fly   667 ITWSFLKSITMMSGELEFEDIFYGDYAVKFP-----VTAHIIFLSFVLLVTVILTNLMVGLAVSD 726
            ....|:..:.||.||.:. .:...|...|.|     |:|.|.|:.|:|.||:||.||:||:||.|
  Fly   740 PFMGFITVLVMMIGEQDL-SLLINDPEGKDPPFLLEVSAQITFVLFLLFVTIILMNLLVGIAVHD 803

  Fly   727 IQGLQVSATLDRLVRQAELVSRLESLFFSRLLRSAPTNLIQLCKRSALLRTSRDKLQFTIRPNDP 791
            ||||:.:|.|.:||||.:|:|.:||..|:..|   ||.|..|...:||:.....::...::|.:|
  Fly   804 IQGLKKTAGLSKLVRQTKLISYIESALFNGYL---PTWLRNLLHYTALVSPQAYRVVLCVKPLNP 865

  Fly   792 RDNQLPEDIKLNVYKLVAERR-------DRNQSLRRRQFENNYNIFSRSLQRQQQPLHTDFLKP- 848
            .:.:||.:|.:..|::...|:       .:|.:.....::|.||        ......|.::.|
  Fly   866 SEKRLPREILMKAYEVGKMRKHFGHTISSKNSAENYLSYKNKYN--------NNNGATTGYVLPD 922

  Fly   849 -EPATGTTKKTPQNLFHMHELLRPRSATNVPQQFRQEAEGTVQMKNQANVLSAVLAEVQAIKTQL 912
             :|..|                             |....|.::.:.|:.:..:..|:|.:|..|
  Fly   923 SDPDAG-----------------------------QFTTLTTKIDDNADRIEFLTQEIQELKQAL 958

  Fly   913 V 913
            :
  Fly   959 I 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365	16/53 (30%)
		ANK repeat	102..130	CDD:293786	7/27 (26%)
		ANK	127..252	CDD:238125	36/128 (28%)
		ANK repeat	132..163	CDD:293786	12/30 (40%)
		Ank_2	137..226	CDD:289560	30/92 (33%)
		ANK repeat	166..196	CDD:293786	11/33 (33%)
		ANK	198..319	CDD:238125	37/120 (31%)
		ANK repeat	200..229	CDD:293786	9/28 (32%)
		Ank_2	203..296	CDD:289560	27/92 (29%)
		ANK repeat	231..262	CDD:293786	3/30 (10%)
		ANK	268..387	CDD:238125	53/119 (45%)
		ANK repeat	268..296	CDD:293786	14/27 (52%)
		Ank_2	270..364	CDD:289560	40/94 (43%)
		ANK repeat	298..329	CDD:293786	13/31 (42%)
		ANK repeat	331..364	CDD:293786	14/32 (44%)
		Ank_5	353..404	CDD:290568	23/50 (46%)
		ANK repeat	366..396	CDD:293786	16/29 (55%)
		Ion_trans	556..734	CDD:278921	70/188 (37%)
wtrw	NP_731193.1	Ank_2	156..241	CDD:289560	29/103 (28%)
		ANK repeat	182..213	CDD:293786	8/44 (18%)
		ANK repeat	215..242	CDD:293786	12/26 (46%)
		ANK	216..341	CDD:238125	49/155 (32%)
		ANK repeat	250..281	CDD:293786	10/30 (33%)
		Ank_2	255..351	CDD:289560	37/125 (30%)
		ANK repeat	283..317	CDD:293786	13/63 (21%)
		ANK	323..443	CDD:238125	53/119 (45%)
		ANK repeat	323..351	CDD:293786	14/27 (52%)
		Ank_2	325..420	CDD:289560	40/94 (43%)
		ANK repeat	353..385	CDD:293786	13/31 (42%)
		ANK repeat	387..420	CDD:293786	14/32 (44%)
		Ank_2	392..>460	CDD:289560	29/67 (43%)
		ANK repeat	422..452	CDD:293786	16/29 (55%)
		Ion_trans	613..812	CDD:278921	74/208 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D180347at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1976
	4	3.820