DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyx and pain

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_611979.1	Gene:	pain / 37985	FlyBaseID:	FBgn0060296	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	809	Identity:	187/809 - (23%)
Similarity:	316/809 - (39%)	Gaps:	206/809 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 CRANAPIAKVLLDFGADPNRWDARKEVTSLHCAASSKSVECILLLLRRKASINIGIEKR------ 200
            ||   ...:..:|.|:..|..:.:.:..::..||.|:....:..||:.:....:.::::
  Fly    57 CR---DFIEACIDHGSQVNYINKKLDKAAISYAADSRDPGNLAALLKYRPGNKVQVDRKYGQLTP 118

  Fly   201 --SALHYAIDVNAVD---CVEILLKYGADPNTPQVYTETPLH-----TASAAGFAKCVQLLLSH- 254
              |......|.||.|   |:::||.|||.||.......||||     :...||..:.:||.|.|
  Fly   119 LNSLAKNLTDENAPDVYSCMQLLLDYGASPNIVDQGEFTPLHHVLRKSKVKAGKKELIQLFLDHP 183

  Fly   255 --------NADVR----SQFGEGKV-TALHLAAENDYVECARLLLEH----------------RA 290
                    |.:||    :||.|.|: ...|...|.|.....|.|.:.                :.
  Fly   184 ELDIDSYRNGEVRRLLQAQFPELKLPEERHTGPEIDIQTLQRTLRDGDETLFEQQFAEYLQNLKG 248

  Fly   291 EVDCRNASHQTPLHLACLSQSI-----GTVDLLISYGANVNAVYRDGR--------TAL------ 336
            ..|.:..:||.. :...|.:||     ...|:::|.|.::|:  |.||        ||:
  Fly   249 GADNQLNAHQEE-YFGLLQESIKRGRQRAFDVILSTGMDINS--RPGRANEANLVETAVIYGNWQ 310

  Fly   337 ---------HAAIVKQSRSLD------------------CCNALLKAG-ADVNKADNYGYTPLHI 373
                     :..:...|:.|:                  |...|:.:. .|:|:||:....||..
  Fly   311 ALERLLKEPNLRLTPDSKLLNAVIGRLDEPPYDGSSHQRCFELLINSDRVDINEADSGRLVPLFF 375

  Fly   374 AALNEFSSCVYTFIEHGADITARTDGRVSALSF--IVRRTPEIIPKLMQKLDSSIKANDQEIGDV 436
            |.....:|.:...:::||.|     |..||...  |....||:   |.:..||.|..|.:..||.
  Fly   376 AVKYRNTSAMQKLLKNGAYI-----GSKSAFGTLPIKDMPPEV---LEEHFDSCITTNGERPGDQ 432

  Fly   437 DCQIKLDFRLLVPSSSMDRGETELLLSLIEVG-------QKRILMHPLCETFLFLKWRRIRKFFL 494
            :.:|.:|::.|: ....|.|..:|...:..:.       .:.:|.|||..:||||||.|:...|.
  Fly   433 NFEIIIDYKNLM-RQERDSGLNQLQDEMAPIAFIAESKEMRHLLQHPLISSFLFLKWHRLSVIFY 496

  Fly   495 MSLAYHTLFVILFTFYVIWVYVRCCKKEELCVAPGYVSTIGYLVIILNLILLGKEVFQMAHGLRG 559
            ::...::||......|.:..:.. ..:..|....|.:|.:|...:||      :|..|.......
  Fly   497 LNFLIYSLFTASIITYTLLKFHE-SDQRALTAFFGLLSWLGISYLIL------RECIQWIMSPVR 554

  Fly   560 YAKYWE--NWLQWTIGT-GVLLCV----TPETVRTDDLTAVPVWQHHVAAIVILLVWLELMMLVG 617
            |  :|.  |.::..:.| .:..|:    ..||.|.            :|...||||.:|..:|||
  Fly   555 Y--FWSITNIMEVALITLSIFTCMESSFDKETQRV------------LAVFTILLVSMEFCLLVG 605

  Fly   618 RFPIFGV--YVQMFTKVAVNFAKFLLAYICLLVAFGLSFAVLF---------------------- 658
            ..|:..:  ::.|..:|:.:|.|....|...::.|.|.|.:||
  Fly   606 SLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATPCPPLGKKE 670

  Fly   659 --NDYPAFENIT---WSFLKSITMMSGE-----LEFEDIFYGDYAVKFPVTAHIIFLSFVLLVTV 713
              ::...|...|   .:.:|:|.|::||     ::|..|:           .::|||.||:.:|:
  Fly   671 GKDEEQGFNTFTKPIEAVIKTIVMLTGEFDAGSIQFTSIY-----------TYLIFLLFVIFMTI 724

  Fly   714 ILTNLMVGLAVSDIQGLQVSATLDRLVRQAELVSRLES----------LFFSRLLRSAPTNLIQL 768
            :|.||:.||||||.|.::..|.|:..:.:..::||.|.          |..:.|.||....|:.:
  Fly   725 VLFNLLNGLAVSDTQVIKAQAELNGAICRTNVLSRYEQVLTGHGRAGFLLGNHLFRSICQRLMNI 789

  Fly   769 CKRSALLRTSRDKLQFTIRPNDPRDNQLP 797
            ......||      |.::.|||.....:|
  Fly   790 YPNYLSLR------QISVLPNDGNKVLIP 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365	2/10 (20%)
		ANK repeat	102..130	CDD:293786
		ANK	127..252	CDD:238125	31/125 (25%)
		ANK repeat	132..163	CDD:293786	5/20 (25%)
		Ank_2	137..226	CDD:289560	21/94 (22%)
		ANK repeat	166..196	CDD:293786	5/29 (17%)
		ANK	198..319	CDD:238125	42/171 (25%)
		ANK repeat	200..229	CDD:293786	13/39 (33%)
		Ank_2	203..296	CDD:289560	35/130 (27%)
		ANK repeat	231..262	CDD:293786	13/48 (27%)
		ANK	268..387	CDD:238125	32/181 (18%)
		ANK repeat	268..296	CDD:293786	6/43 (14%)
		Ank_2	270..364	CDD:289560	26/156 (17%)
		ANK repeat	298..329	CDD:293786	9/35 (26%)
		ANK repeat	331..364	CDD:293786	10/74 (14%)
		Ank_5	353..404	CDD:290568	14/51 (27%)
		ANK repeat	366..396	CDD:293786	7/29 (24%)
		Ion_trans	556..734	CDD:278921	53/218 (24%)
pain	NP_611979.1	ANK	56..180	CDD:238125	31/125 (25%)
		ANK repeat	82..111	CDD:293786	5/28 (18%)
		ANK repeat	113..152	CDD:293786	13/38 (34%)
		ANK	303..406	CDD:238125	19/107 (18%)
		Ank_2	303..398	CDD:289560	17/99 (17%)
		ANK repeat	324..366	CDD:293786	6/41 (15%)
		ANK repeat	368..393	CDD:293786	4/24 (17%)
		Ion_trans	525..746	CDD:278921	61/251 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810