DRSC/TRiP Functional Genomics Resources

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Protein Alignment pyx and SOWAHD

DIOPT Version :9

Sequence 1:NP_612015.1 Gene:pyx / 38037 FlyBaseID:FBgn0035113 Length:956 Species:Drosophila melanogaster
Sequence 2:NP_001099046.1 Gene:SOWAHD / 347454 HGNCID:32960 Length:315 Species:Homo sapiens


Alignment Length:326 Identity:67/326 - (20%)
Similarity:105/326 - (32%) Gaps:117/326 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   169 TSLHCAASSKSVECILLLLRRKASIN--IGIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVY 231
            |.:|.||.|.         ||:.::.  :|:::.:...:..:..|.:     |...:.|.:.::.
Human    59 TLMHSAAGSG---------RRRGALRELLGLQRAAPAGWLSEERAEE-----LGGPSGPGSSRLC 109

  Fly   232 TETPLHT---ASAAGFAKCVQLLLSHNAD--VRSQFGEGKVTALHLAAENDYVECARLLLEH--- 288
            .|...|.   |:|.|..:.::.||....:  :|.....| .:.||..|::...|  .|:|.|   
Human   110 LEPREHAWILAAAEGRYEVLRELLEAEPELLLRGDPITG-YSVLHWLAKHGRHE--ELILVHDFA 171

  Fly   289 -----RAEVDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVKQSRSLD 348
                 |.:|....:...||||||.|..                          |..::|      
Human   172 LRRGLRLDVSAPGSGGLTPLHLAALQG--------------------------HDMVIK------ 204

  Fly   349 CCNALLKA-GADVNKADNYGYTPLHIA------ALNEFSSCVYTFIEHGADIT------------ 394
               .|:.| |||..:.|:.|:...|..      .|.|.|......:|.|:..|            
Human   205 ---VLVGALGADATRRDHSGHRACHYLRPDAPWRLRELSGAEEWEMESGSGCTNLNNNSSGTTAW 266

  Fly   395 ----------ARTDGRVSALSFIVRRTPEIIPKLMQKLDSSIKANDQEIGDVDCQIKLDFRLLVP 449
                      ..|..||:|                    |..||.| ..|....|:...||.|.|
Human   267 RAASAVGATAVETSRRVAA--------------------SRTKAKD-TAGSRVAQMHSLFRHLFP 310

  Fly   450 S 450
            |
Human   311 S 311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pyxNP_612015.1 Ank_4 99..153 CDD:290365
ANK repeat 102..130 CDD:293786
ANK 127..252 CDD:238125 16/87 (18%)
ANK repeat 132..163 CDD:293786
Ank_2 137..226 CDD:289560 10/58 (17%)
ANK repeat 166..196 CDD:293786 7/28 (25%)
ANK 198..319 CDD:238125 28/133 (21%)
ANK repeat 200..229 CDD:293786 3/28 (11%)
Ank_2 203..296 CDD:289560 21/105 (20%)
ANK repeat 231..262 CDD:293786 8/35 (23%)
ANK 268..387 CDD:238125 29/133 (22%)
ANK repeat 268..296 CDD:293786 9/35 (26%)
Ank_2 270..364 CDD:289560 23/102 (23%)
ANK repeat 298..329 CDD:293786 7/30 (23%)
ANK repeat 331..364 CDD:293786 7/33 (21%)
Ank_5 353..404 CDD:290568 17/79 (22%)
ANK repeat 366..396 CDD:293786 8/57 (14%)
Ion_trans 556..734 CDD:278921
SOWAHDNP_001099046.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
ANK 1 112..141 6/28 (21%)
ANK 147..>231 CDD:238125 27/121 (22%)
ANK 2 147..162 4/15 (27%)
Ank_2 <148..218 CDD:289560 24/107 (22%)
ANK repeat 148..184 CDD:293786 10/38 (26%)
ANK repeat 186..218 CDD:293786 14/66 (21%)
ANK 3 186..216 14/64 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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