DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyx and asb12a

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001119848.1	Gene:	asb12a / 322927	ZFINID:	ZDB-GENE-030131-1647	Length:	305	Species:	Danio rerio

Alignment Length:	180	Identity:	52/180 - (28%)
Similarity:	89/180 - (49%)	Gaps:	27/180 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 TSLHCAASSKSVECILLLLRRKASIN-IGIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYT 232
            |.|..|||...:.|:.|||...|.:: :.::.::.|..|:....:.||..||:.||:||...:..
Zfish    55 TPLRMAASKGHLRCLQLLLAHGADVDRLDVKAQTPLFTAVCGRYLSCVLALLRAGANPNGSHLNN 119

  Fly   233 ETPLHTASAAGFAKCVQLLLSHNADVRSQFGEGKVT-----------ALHLAAENDYVECARLLL 286
            .:|:.||:..|..:.::.||.|.|:|.::   .|||           .|:|:|...:::|.::||
Zfish   120 SSPVLTAAREGDPEILRQLLQHGAEVNAR---SKVTLWASGVAVCSGPLYLSAIYGHLDCFKMLL 181

  Fly   287 EHRAE---------VDCRNASHQTPLHLACLSQSIGT--VDLLISYGANV 325
            ...|:         ::.|....:|.:.| ||....|.  :.|||.:||||
Zfish   182 LFGADPNYNSPEEKLNGRATQQKTVMEL-CLRHGCGVEYIQLLIDFGANV 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365
		ANK repeat	102..130	CDD:293786
		ANK	127..252	CDD:238125	24/83 (29%)
		ANK repeat	132..163	CDD:293786
		Ank_2	137..226	CDD:289560	18/57 (32%)
		ANK repeat	166..196	CDD:293786	10/27 (37%)
		ANK	198..319	CDD:238125	36/142 (25%)
		ANK repeat	200..229	CDD:293786	10/28 (36%)
		Ank_2	203..296	CDD:289560	29/112 (26%)
		ANK repeat	231..262	CDD:293786	9/30 (30%)
		ANK	268..387	CDD:238125	21/80 (26%)
		ANK repeat	268..296	CDD:293786	8/47 (17%)
		Ank_2	270..364	CDD:289560	20/67 (30%)
		ANK repeat	298..329	CDD:293786	12/30 (40%)
		ANK repeat	331..364	CDD:293786
		Ank_5	353..404	CDD:290568
		ANK repeat	366..396	CDD:293786
		Ion_trans	556..734	CDD:278921
asb12a	NP_001119848.1	ANK	55..181	CDD:238125	36/128 (28%)
		ANK repeat	55..83	CDD:293786	10/27 (37%)
		Ank_2	57..148	CDD:289560	28/90 (31%)
		ANK repeat	85..116	CDD:293786	10/30 (33%)
		ANK repeat	118..148	CDD:293786	9/29 (31%)
		Ank_4	119..181	CDD:290365	16/64 (25%)
		ANK repeat	162..200	CDD:293786	7/37 (19%)
		Ank_2	165..>230	CDD:289560	18/65 (28%)
		ANK repeat	202..228	CDD:293786	8/26 (31%)
		SOCS	257..297	CDD:295349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000