DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyx and ANK2

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001373103.1	Gene:	ANK2 / 287	HGNCID:	493	Length:	4183	Species:	Homo sapiens

Alignment Length:	456	Identity:	125/456 - (27%)
Similarity:	191/456 - (41%)	Gaps:	68/456 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DEVKETLTE--------SPGGKHVVDMVQSG----CFLELMTDSA-------DCNLALICCSVFG 110
            |:|.|.|.|        :..|...:.|...|    |...|:...|       |...||...:..|
Human   329 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCG 393

  Fly   111 SVENTLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPNRWDARKEVTSLHCAA 175
            ....|..||.. .|:||.....|.||||.||.:....:.::|:.:||.... .....:|.:|.||
Human   394 HYRVTKLLLDK-RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAA 456

  Fly   176 SSKSVECILLLLRRKASINI-GIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYTETPLHTA 239
            ....:..:||||:..||.:: .|...:|||.|.....|:.|..||:.||..:......:||||.|
Human   457 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 521

  Fly   240 SAAGFAKCVQLLLSHNA--DVRSQFG---------EGKV---------------------TALHL 272
            |..|..:.|||||.|.|  |..:..|         ||:|                     |.||:
Human   522 SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 586

  Fly   273 AAENDYVECARLLLEHRAEVDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALH 337
            ||:...::.|:|||:.||..|....:..||||:|....:.....||:..||:.:|..::|.|.||
Human   587 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 651

  Fly   338 AAIVKQSRSLDCCNALLKAGADVNKADNYGYTPLHIAALNEFSSCVYTFIEHGADITARTDGRVS 402
            .|..|  ..:...:.||..||:.|.....|.||||:|:....:..|...::.||:|...|...::
Human   652 IAAKK--NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLT 714

  Fly   403 ALSFIVRRTPEIIPKLMQKLDSSIKANDQEIGDVDCQIKLDFRLLVPSSSMDRGETELLLSLIEV 467
            :|....:.....:..::.|..:          |.|...||.:..|:.:...  |..:::..|::.
Human   715 SLHLAAQEDKVNVADILTKHGA----------DQDAHTKLGYTPLIVACHY--GNVKMVNFLLKQ 767

  Fly   468 G 468
            |
Human   768 G 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365	16/53 (30%)
		ANK repeat	102..130	CDD:293786	9/27 (33%)
		ANK	127..252	CDD:238125	42/125 (34%)
		ANK repeat	132..163	CDD:293786	10/30 (33%)
		Ank_2	137..226	CDD:289560	28/89 (31%)
		ANK repeat	166..196	CDD:293786	10/30 (33%)
		ANK	198..319	CDD:238125	47/152 (31%)
		ANK repeat	200..229	CDD:293786	10/28 (36%)
		Ank_2	203..296	CDD:289560	40/124 (32%)
		ANK repeat	231..262	CDD:293786	15/32 (47%)
		ANK	268..387	CDD:238125	40/118 (34%)
		ANK repeat	268..296	CDD:293786	12/27 (44%)
		Ank_2	270..364	CDD:289560	32/93 (34%)
		ANK repeat	298..329	CDD:293786	10/30 (33%)
		ANK repeat	331..364	CDD:293786	11/32 (34%)
		Ank_5	353..404	CDD:290568	16/50 (32%)
		ANK repeat	366..396	CDD:293786	10/29 (34%)
		Ion_trans	556..734	CDD:278921
ANK2	NP_001373103.1	Ank_2	35..>311	CDD:423045
		ANK repeat	80..111	CDD:293786
		ANK repeat	113..144	CDD:293786
		ANK repeat	146..171	CDD:293786
		Ank_2	202..>444	CDD:423045	31/116 (27%)
		ANK repeat	212..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..313	CDD:293786
		ANK repeat	315..345	CDD:293786	5/15 (33%)
		ANK repeat	348..379	CDD:293786	6/30 (20%)
		ANK repeat	381..411	CDD:293786	10/30 (33%)
		ANK repeat	414..445	CDD:293786	10/31 (32%)
		PHA03095	421..>706	CDD:222980	87/287 (30%)
		ANK repeat	447..478	CDD:293786	10/30 (33%)
		ANK repeat	480..511	CDD:293786	10/30 (33%)
		ANK repeat	513..542	CDD:293786	14/28 (50%)
		ANK repeat	546..571	CDD:293786	4/24 (17%)
		Ank_2	578..>802	CDD:423045	54/205 (26%)
		ANK repeat	579..604	CDD:293786	9/24 (38%)
		ANK repeat	612..643	CDD:293786	10/30 (33%)
		ANK repeat	645..676	CDD:293786	11/32 (34%)
		ANK repeat	678..707	CDD:293786	10/28 (36%)
		ANK repeat	711..742	CDD:293786	4/40 (10%)
		ANK repeat	744..775	CDD:293786	5/27 (19%)
		ANK repeat	777..806	CDD:293786
		Ank_4	778..830	CDD:372654
		ZU5	1013..1150	CDD:128514
		UPA_2	1371..1500	CDD:375346
		PspC_subgroup_1	1549..>1922	CDD:411407
		PTZ00449	<1717..2161	CDD:185628
		Streccoc_I_II	<1843..>2027	CDD:411384
		Spc7_N	<2493..>2634	CDD:373822
		rad2	<3031..>3565	CDD:273166
		PRK14949	<3196..>3442	CDD:237863
		Death_ank2	3614..3697	CDD:260066
		NESP55	<3770..>3884	CDD:115071
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940