DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyx and ANK1

DIOPT Version :9

Sequence 1:NP_612015.1 Gene:pyx / 38037 FlyBaseID:FBgn0035113 Length:956 Species:Drosophila melanogaster
Sequence 2:XP_011542792.1 Gene:ANK1 / 286 HGNCID:492 Length:1969 Species:Homo sapiens


Alignment Length:391 Identity:117/391 - (29%)
Similarity:168/391 - (42%) Gaps:49/391 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 DCNLALICCSVFGSVENTLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPNRW 162
            |....|.|.:..|.. |.:.||...||:||:|.:.|.||||.|....:......||:..|. ...
Human   534 DDQTPLHCAARIGHT-NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QAC 596

  Fly   163 DARKEVTSLHCAASSKSVECILLLLRRKASIN-IGIEKRSALHYAIDVNAVDCVEILLKYGADPN 226
            ..:|..|.||.||....|....|||.|.|..| .|....:.||.|:..|.:|.|::||..|..|:
Human   597 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 661

  Fly   227 TPQVYTETPLHTASAAGFAKCVQLLLSHNADVRSQFGEGKVTALHLAAENDYVECARLLLEHRAE 291
            :|.....||||.|:.....:..:.||.:.....::..:| ||.|||||:..:.|...|||..:|.
Human   662 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG-VTPLHLAAQEGHAEMVALLLSKQAN 725

  Fly   292 VDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVKQSRSLDCCNALLKA 356
            .:..|.|..|||||......:...|:||.:|..|:|..|.|.|.||.|  ....::.....||:.
Human   726 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA--SHYGNIKLVKFLLQH 788

  Fly   357 GADVNKADNYGYTPLHIAALNEFSSCVYTFIEHGAD------------ITARTDGRVSA------ 403
            .||||.....||:|||.||....:..|...:::||.            ..|:..|.:|.      
Human   789 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 853

  Fly   404 ----LSFIV------RRTPEIIPKLMQKLDS--------------SIKANDQEIGDVDCQIK-LD 443
                .||::      ...||.:.:::...:.              |.||..::..|||.:.: ||
Human   854 VTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLD 918

  Fly   444 F 444
            |
Human   919 F 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pyxNP_612015.1 Ank_4 99..153 CDD:290365 17/53 (32%)
ANK repeat 102..130 CDD:293786 10/27 (37%)
ANK 127..252 CDD:238125 41/125 (33%)
ANK repeat 132..163 CDD:293786 9/30 (30%)
Ank_2 137..226 CDD:289560 29/89 (33%)
ANK repeat 166..196 CDD:293786 13/30 (43%)
ANK 198..319 CDD:238125 39/120 (33%)
ANK repeat 200..229 CDD:293786 10/28 (36%)
Ank_2 203..296 CDD:289560 31/92 (34%)
ANK repeat 231..262 CDD:293786 7/30 (23%)
ANK 268..387 CDD:238125 44/118 (37%)
ANK repeat 268..296 CDD:293786 11/27 (41%)
Ank_2 270..364 CDD:289560 35/93 (38%)
ANK repeat 298..329 CDD:293786 12/30 (40%)
ANK repeat 331..364 CDD:293786 11/32 (34%)
Ank_5 353..404 CDD:290568 19/72 (26%)
ANK repeat 366..396 CDD:293786 10/41 (24%)
Ion_trans 556..734 CDD:278921
ANK1XP_011542792.1 ANK 47..163 CDD:238125
ANK repeat 47..75 CDD:293786
ANK 108..229 CDD:238125
ANK repeat 109..140 CDD:293786
Ank_2 114..204 CDD:289560
ANK repeat 143..173 CDD:293786
ANK 170..324 CDD:238125
ANK repeat 175..206 CDD:293786
ANK repeat 208..232 CDD:293786
ANK repeat 241..268 CDD:293786
Ank_2 242..333 CDD:289560
ANK 265..390 CDD:238125
ANK repeat 271..301 CDD:293786
ANK repeat 303..334 CDD:293786
Ank_2 308..397 CDD:289560
ANK repeat 336..367 CDD:293786
ANK repeat 369..400 CDD:293786
Ank 402..432 CDD:278452
ANK repeat 405..433 CDD:293786
ANKYR 406..619 CDD:223738 28/86 (33%)
ANK 430..555 CDD:238125 6/21 (29%)
ANK repeat 435..466 CDD:293786
ANK repeat 468..499 CDD:293786
ANK repeat 501..532 CDD:293786
ANK 529..654 CDD:238125 41/121 (34%)
ANK repeat 534..563 CDD:293786 10/29 (34%)
ANK repeat 568..598 CDD:293786 9/30 (30%)
ANK repeat 600..631 CDD:293786 13/30 (43%)
Ank_2 605..696 CDD:289560 30/90 (33%)
ANK repeat 633..661 CDD:293786 9/27 (33%)
ANK repeat 666..697 CDD:293786 7/30 (23%)
ANK 666..695 CDD:197603 7/28 (25%)
ANK 694..819 CDD:238125 46/127 (36%)
ANK repeat 699..730 CDD:293786 13/31 (42%)
Ank_2 704..795 CDD:289560 35/92 (38%)
ANK repeat 732..763 CDD:293786 12/30 (40%)
ANK repeat 765..796 CDD:293786 11/32 (34%)
Ank_5 785..839 CDD:290568 16/53 (30%)
ANK repeat 798..826 CDD:293786 10/27 (37%)
ZU5 984..1088 CDD:128514
Death_ank1 1474..1557 CDD:260067
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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