DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyx and Trpa1

DIOPT Version :9

Sequence 1:NP_612015.1 Gene:pyx / 38037 FlyBaseID:FBgn0035113 Length:956 Species:Drosophila melanogaster
Sequence 2:NP_808449.1 Gene:Trpa1 / 277328 MGIID:3522699 Length:1125 Species:Mus musculus


Alignment Length:1082 Identity:230/1082 - (21%)
Similarity:400/1082 - (36%) Gaps:319/1082 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 LELMTDSADC----------NLALICCSVFGSVENTLFLLKHYNADPNVADSRGRTPLHFA---- 140
            :||:.:.:.|          |..|.|.:....||:..|||.. .|:||:.:....:|||.|    
Mouse    80 MELIINGSSCEVLNIMDGYGNTPLHCAAEKNQVESVKFLLSQ-GANPNLRNRNMMSPLHIAVHGM 143

  Fly   141 ------------------------------CCRANAPIAKVLLDFGA---DPNRWDARKEVTSLH 172
                                          |.:.|:...::||:.||   ..|:|..    ..:|
Mouse   144 YNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSEALQILLEKGAKLCKSNKWGD----YPVH 204

  Fly   173 CAASSKSVECILLLL--------RRKASIN-IGIEKRSALHYAIDVNAVDCVEILLKYGADPNTP 228
            .||.|.:.:|:.|:|        .|:..|| :..:|.|.||.|:....:|.:::.|..||..:..
Mouse   205 QAAFSGAKKCMELILAYGEKNGYSRETHINFVNHKKASPLHLAVQSGDLDMIKMCLDNGAHIDMM 269

  Fly   229 QVYTETPLHTASAAGFAKCVQLLLSH---NADVRSQFGEGKVTALHLAAENDYVECARLLLEHRA 290
            :......||.|:..|....|:|::|.   ::|:.:.....:.|.||.|:..|:.:.|..|:...|
Mouse   270 ENAKCMALHFAATQGATDIVKLMISSYTGSSDIVNAVDGNQETLLHRASLFDHHDLAEYLISVGA 334

  Fly   291 EVDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAI--------------- 340
            :::..::..::||.||..|.|...|:||:..||.|:.....||..||..:               
Mouse   335 DINSTDSEGRSPLILATASASWNIVNLLLCKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFMQ 399

  Fly   341 ---VKQ------------------------------------SRSLD---------------CCN 351
               :|:                                    |:|.|               .|.
Mouse   400 MQHIKELVMDEDNDGCTPLHYACRQGVPVSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQ 464

  Fly   352 ALLKAGAD---VNKADNYGYTPLHIAALNEFSSCVYTFIEHGA---------------------- 391
            .||:..:|   :|:.|.:|.||||:||.|.....|...::.||                      
Mouse   465 RLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQ 529

  Fly   392 ------DITARTDGRV-----SALSFIVR------------------------------------ 409
                  |...:...|:     :||.|..|                                    
Mouse   530 TMKVILDTNLKCTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRK 594

  Fly   410 --------------------------RTP-----EIIPKLMQ-KLDSSIKANDQEIGDVDCQIKL 442
                                      |.|     |.:|:.|: .||..:..:.::....|..|:.
Mouse   595 EVVLTTIRNKRWDECLQVFTHNSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEY 659

  Fly   443 DFRLL----------VPSSSMDRGETELLLSLIEVGQKRILMHPLCETFLFLKWRRIR-KFFLMS 496
            :|:.|          .|:..:......:|..:::..:..:|.||:|..:|.:||.... :..:|:
Mouse   660 NFKYLQCPLSMTKKVAPTQDVVYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRAHMMN 724

  Fly   497 LAYHTLFVILFTFYVIWVY-------------VRCCKKEELCVAPGYVSTIGYLVIILNLIL-LG 547
            |..:.|.:|..|..|:.:.             .....:|.:.....:...|..:::.|:.|. ..
Mouse   725 LGSYCLGLIPMTLLVVKIQPGMAFNSTGIINGTSSTHEERIDTLNSFPIKICMILVFLSSIFGYC 789

  Fly   548 KEVFQMAHGLRGYAKYWENWLQWTIGTGVLLCVTPETVRTDDLTAVPVWQHHVAAIVILLVWLEL 612
            |||.|:....|.|...:.|.|:|.|.|..::.|.|..:   ::.|...||  ..||.|...|:..
Mouse   790 KEVIQIFQQKRNYFLDYNNALEWVIYTTSIIFVLPLFL---NIPAYMQWQ--CGAIAIFFYWMNF 849

  Fly   613 MMLVGRFPIFGVYVQMFTKVAVNFAKFLLAYICLLVAFGLSFAVLFNDYPAFENITWSFLKSITM 677
            ::.:.||...|:::.|...:.....:....:|.||:||||||.||.|...||.....|.:::.:|
Mouse   850 LLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDAFSTPLLSLIQTFSM 914

  Fly   678 MSGELEFED-----IFYGDYAVKFPVTAHIIFLSFVLLVTVILTNLMVGLAVSDIQGLQVSATLD 737
            |.|::.:.|     :|..:.|  :||......::|.:.|.::|.||::||||.||..:|..|:|.
Mouse   915 MLGDINYRDAFLEPLFRNELA--YPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLK 977

  Fly   738 RLVRQAELVSRLES---LFFSRLLRSAPTNLIQLCKRSALLRTSRDKLQFTIRPNDPRDNQLPED 799
            |:..|.||.:.||.   |::.|          ::.:||.:           :.||.||..::...
Mouse   978 RIAMQVELHTNLEKKLPLWYLR----------KVDQRSTI-----------VYPNRPRHGRMLRF 1021

  Fly   800 IK--LNVYKLVAERRDRNQSLRRRQFENNYNI--FSRSLQRQQQPLHTDFLKPEPATGTTKKTPQ 860
            ..  ||:.:...|..:.:..|.....:..|.:  .:..|::|.:.:.....|.|..:.|..:...
Mouse  1022 FHYFLNMQETRQEVPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISETEDEDNH 1086

  Fly   861 NLFHMHELLRPRSATNVPQQFRQEAEGTVQMKNQAN-VLSAV 901
            ..|                |.|.:.|...||.::.| ||:||
Mouse  1087 CSF----------------QDRFKKERLEQMHSKWNFVLNAV 1112

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pyxNP_612015.1 Ank_4 99..153 CDD:290365 18/97 (19%)
ANK repeat 102..130 CDD:293786 10/27 (37%)
ANK 127..252 CDD:238125 38/170 (22%)
ANK repeat 132..163 CDD:293786 11/67 (16%)
Ank_2 137..226 CDD:289560 30/134 (22%)
ANK repeat 166..196 CDD:293786 10/38 (26%)
ANK 198..319 CDD:238125 33/123 (27%)
ANK repeat 200..229 CDD:293786 8/28 (29%)
Ank_2 203..296 CDD:289560 23/95 (24%)
ANK repeat 231..262 CDD:293786 8/33 (24%)
ANK 268..387 CDD:238125 43/190 (23%)
ANK repeat 268..296 CDD:293786 8/27 (30%)
Ank_2 270..364 CDD:289560 32/165 (19%)
ANK repeat 298..329 CDD:293786 12/30 (40%)
ANK repeat 331..364 CDD:293786 13/104 (13%)
Ank_5 353..404 CDD:290568 18/86 (21%)
ANK repeat 366..396 CDD:293786 12/57 (21%)
Ion_trans 556..734 CDD:278921 55/182 (30%)
Trpa1NP_808449.1 Ank_2 41..129 CDD:372319 14/49 (29%)
ANK 1 63..94 3/13 (23%)
ANK repeat 67..96 CDD:293786 3/15 (20%)
ANK repeat 98..129 CDD:293786 11/31 (35%)
ANK 2 98..127 10/29 (34%)
Ank_2 101..>373 CDD:393464 69/276 (25%)
ANK repeat 131..163 CDD:293786 4/31 (13%)
ANK 3 131..161 4/29 (14%)
ANK 4 165..194 6/28 (21%)
ANK repeat 165..190 CDD:293786 4/24 (17%)
ANK repeat 198..237 CDD:293786 11/42 (26%)
ANK 5 198..227 8/32 (25%)
ANK 6 239..268 9/28 (32%)
ANK repeat 242..307 CDD:293786 16/64 (25%)
ANK 7 272..301 7/28 (25%)
ANK repeat 309..340 CDD:293786 8/30 (27%)
ANK 8 309..338 8/28 (29%)
ANK repeat 342..373 CDD:293786 12/30 (40%)
ANK 9 342..371 12/28 (43%)
ANK repeat 413..444 CDD:293786 1/30 (3%)
ANK 10 413..442 0/28 (0%)
Ank_2 418..507 CDD:372319 18/88 (20%)
ANK repeat 446..480 CDD:293786 6/33 (18%)
ANK 11 446..475 5/28 (18%)
ANK repeat 482..512 CDD:293786 11/29 (38%)
ANK 12 482..511 11/28 (39%)
Ank_2 487..578 CDD:372319 14/90 (16%)
ANK repeat 514..546 CDD:293786 2/31 (6%)
ANK 13 514..543 1/28 (4%)
ANK 14 548..577 4/28 (14%)
ANK repeat 548..573 CDD:293786 4/24 (17%)
Ion_trans <799..975 CDD:366146 55/182 (30%)
Inositolphosphate binding. /evidence=ECO:0000250|UniProtKB:O75762 1048..1054 1/5 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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