DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyx and trpa-1

DIOPT Version :9

Sequence 1:NP_612015.1 Gene:pyx / 38037 FlyBaseID:FBgn0035113 Length:956 Species:Drosophila melanogaster
Sequence 2:NP_502249.3 Gene:trpa-1 / 178118 WormBaseID:WBGene00007801 Length:1211 Species:Caenorhabditis elegans


Alignment Length:980 Identity:225/980 - (22%)
Similarity:389/980 - (39%) Gaps:274/980 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 KRSISSEANSAGVFSDEAHEIFARQQQNQILWDLDEVKETLTESPGGKHVVDMVQSGCFLELMTD 95
            |:.:..|..::..:.|...|:.....:...|    ||.:.|.|:.|.|:.::.|::         
 Worm   295 KKILQMEKKNSCKWMDREKELIHFAAEKGFL----EVLKALVEAGGNKNELNEVKA--------- 346

  Fly    96 SADCNLALICCSVFGSVENTLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPN 160
                 :.|...:....:|...:|::....:.:|.|.:|.|||..|...                 
 Worm   347 -----VPLHVAAQMNQLEVVSYLIEEEKDNIDVVDEQGLTPLMMAVTH----------------- 389

  Fly   161 RWDARKEVTSLHCAASSKSVECILLLLRRKASINI-GIEKRSALHYAIDVNAVDCVEILLKY--- 221
              |::|               |:..|:.:||::.| ..::|:.:......||:..||.:|.:   
 Worm   390 --DSKK---------------CVEYLIAKKANLTITDKDERTPVFIGAKFNALSSVEYILDHLRK 437

  Fly   222 -----------GADPNTPQVYTE---------------TPLHTASAAGFAKCVQLLLSHNADVRS 260
                       ....||.::.:|               ||:|..::.|:.:.:|||..|.|.: :
 Worm   438 KNKETERSALKSPTRNTLRIVSEDVRRTMVNMVDRDQNTPMHIVASNGYLEMMQLLQKHGASI-T 501

  Fly   261 QFGEGKVT----------------------------------ALHLAAENDYVECARLLLEHRAE 291
            |..|.:.|                                  ||||||.:.:....::||::.|:
 Worm   502 QVNEDEETALHRAAIGGQTGAVRQLLEWDIRLLLMKDEMGNSALHLAARSGHDATTKVLLDNGAD 566

  Fly   292 VDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVKQSRSLDCCNALLKA 356
            .:.:|:..:|||.:|..|..:.|...|::.||.:.: ..|.:|.||.|....:.|:  ....:..
 Worm   567 KEAKNSYQKTPLQVAVDSGKLETCQRLVAKGAQIES-SSDTKTVLHTAAFYGNESI--VRYFIAE 628

  Fly   357 GADVNKADNYGYTPLHIAALNEFSSCVYTFIE--------------------HGADITARTDGRV 401
            |..:::.|..|.|...||..|:.......|:|                    :..::..||..|.
 Worm   629 GVTIDRRDEEGKTAFDIACENDHKDVARAFLETDQWKNLMIPCDVIPLDKHRNPVNMKRRTPFRT 693

  Fly   402 SALSFIVRRTPEI--------IPKLMQKLDS--SIKAN-------------------DQEIG--- 434
                 ::.:.||:        |.|..::.||  |:..|                   :|.||   
 Worm   694 -----LLTKFPELASFVMDNCIEKSKEETDSTQSVAYNFEFLDDTYMMRCVSDDGTGEQLIGCKS 753

  Fly   435 --DVDCQIKLDFRLLVPSSSMDRGETELLLSLIEVGQK-RILMHPLCETFLFLKWRRI-RKFFLM 495
              |.|.:::.|.:..  :|:.||......|.|:...:| .:|.|||.:..|..||.|: |..:..
 Worm   754 AYDEDFKLEKDAQSY--ASNYDRVYKYHPLKLMADAEKLHLLNHPLSKALLKYKWNRLGRPMYYF 816

  Fly   496 SLAYHTLFVILFTFYV--------IWVYVRCCKKE-----ELCVAPGYVST---IGYLVIILNL- 543
            :|..:.:|::..|.||        :|........|     |.|  |...:|   :.:.:||..| 
 Worm   817 ALFMYLVFIVSLTQYVRHTKAPYNVWNEESYYDSEYFDENETC--PQINTTKPDVVWKIIIQTLA 879

  Fly   544 ---ILLGKEVFQMAHGLRGYAKYWENWLQWTIGTGVLL-------CVTPETVRTDDLTAVPVWQH 598
               ||:  |.||:......|...||||:...|.:..|:       |.....||.:       ||.
 Worm   880 VCQILV--ECFQLFQRKFAYLVNWENWIDCFIYSTALITVYDFSECSATSGVRQN-------WQW 935

  Fly   599 HVAAIVILLVWLELMMLVGRFPIFGVYVQMFTKVAVNFAKFLLAYICLLVAFGLSFAVLFNDYPA 663
            .:||:.|...|:.|:.::.:.|.||::|.||..:...|.:|...::..::||..||.|:..:.|.
 Worm   936 ILAALCIFFGWINLLFMIRKMPRFGIFVVMFVDIVKTFFRFFPVFVLFIIAFSSSFYVILQNRPE 1000

  Fly   664 FENITWSFLKSITMMSGELEFEDIFYGD---YAVKFPVTAH-----IIFLSFVLLVTVILTNLMV 720
            |..|..|.||:..||.||.||..||:||   :|.|....||     .:|..|.:::|::|.||:|
 Worm  1001 FSTIFMSPLKTTVMMIGEFEFTGIFHGDETTHAEKMFGPAHTAVACALFFFFCIIMTILLMNLLV 1065

  Fly   721 GLAVSDIQGLQVSATLDRLVRQAELVSRLE-SLFFSRLLRSAPTNLIQLCKRSALLRTS------ 778
            ||||.||:|:|..|.|.||..|.:||.::| ||.|          .||..|:.|..|.:      
 Worm  1066 GLAVDDIKGVQEKAELKRLAMQVDLVLQIEASLHF----------FIQRTKKYATCRYATFPYGK 1120

  Fly   779 -------------RDKLQFTIRPNDPRDNQLPEDIKLNVYKLVAE------RRDRNQSLRRRQFE 824
                         |.:...:: ..||..:::        |:..||      ::.:||:.:.:..:
 Worm  1121 LHKTGFAGWWSNFRRRFGLSV-STDPEIDEM--------YEREAEFTSEMTQKLQNQAAKLKNIQ 1176

  Fly   825 NNYNI 829
            .|.::
 Worm  1177 ENIDV 1181

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pyxNP_612015.1 Ank_4 99..153 CDD:290365 10/53 (19%)
ANK repeat 102..130 CDD:293786 4/27 (15%)
ANK 127..252 CDD:238125 29/154 (19%)
ANK repeat 132..163 CDD:293786 5/30 (17%)
Ank_2 137..226 CDD:289560 15/103 (15%)
ANK repeat 166..196 CDD:293786 6/30 (20%)
ANK 198..319 CDD:238125 37/183 (20%)
ANK repeat 200..229 CDD:293786 8/42 (19%)
Ank_2 203..296 CDD:289560 29/155 (19%)
ANK repeat 231..262 CDD:293786 10/45 (22%)
ANK 268..387 CDD:238125 33/152 (22%)
ANK repeat 268..296 CDD:293786 10/61 (16%)
Ank_2 270..364 CDD:289560 25/93 (27%)
ANK repeat 298..329 CDD:293786 9/30 (30%)
ANK repeat 331..364 CDD:293786 7/32 (22%)
Ank_5 353..404 CDD:290568 12/70 (17%)
ANK repeat 366..396 CDD:293786 7/49 (14%)
Ion_trans 556..734 CDD:278921 65/192 (34%)
trpa-1NP_502249.3 Ank_4 51..104 CDD:290365
ANK repeat 51..81 CDD:293786
ANK 78..227 CDD:238125
ANK repeat 86..114 CDD:293786
Ank_2 88..204 CDD:289560
ANK repeat 116..171 CDD:293786
ANK 168..298 CDD:238125 1/2 (50%)
ANK repeat 173..204 CDD:293786
ANK repeat 206..237 CDD:293786
Ank_4 208..258 CDD:290365
Ank_2 244..342 CDD:289560 11/50 (22%)
ANK repeat 280..310 CDD:293786 2/14 (14%)
Ank_2 316..409 CDD:289560 25/144 (17%)
ANK repeat 316..342 CDD:293786 7/29 (24%)
ANK 339..493 CDD:238125 32/201 (16%)
ANK repeat 344..376 CDD:293786 5/45 (11%)
ANK repeat 378..409 CDD:293786 12/64 (19%)
Ank_2 383..504 CDD:289560 28/155 (18%)
ANK 468..594 CDD:238125 28/126 (22%)
ANK repeat 473..504 CDD:293786 10/31 (32%)
Ank_2 479..571 CDD:289560 19/92 (21%)
ANK repeat 506..538 CDD:293786 1/31 (3%)
ANK 536..659 CDD:238125 32/125 (26%)
ANK repeat 540..571 CDD:293786 9/30 (30%)
Ank_2 545..636 CDD:289560 25/93 (27%)
ANK repeat 573..601 CDD:293786 9/27 (33%)
ANK repeat 605..636 CDD:293786 7/32 (22%)
Ion_trans 857..1080 CDD:278921 77/233 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 116 1.000 Domainoid score I3728
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.940

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