DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyx and unc-44

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001367345.1	Gene:	unc-44 / 177366	WormBaseID:	WBGene00006780	Length:	6994	Species:	Caenorhabditis elegans

Alignment Length:	391	Identity:	105/391 - (26%)
Similarity:	171/391 - (43%)	Gaps:	54/391 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDF--------------------------- 155
            ||...:||||.....|.||||.||.:....:.::||.:
Worm   377 LLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIV 441

  Fly   156 ------GADPNRWDARKEVTSLHCAASSKSVECILLLLRRKASINI-GIEKRSALHYAIDVNAVD 213
                  ||:|:....|.| |.||.||.:...:.:.:|:|..|.::. ..|.::.||.|..:...|
Worm   442 IYLLQQGANPDVETVRGE-TPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTD 505

  Fly   214 CVEILLKYGADPNTPQVYTETPLHTASAAGFAKCVQLLLSHNADVRSQFGEGKVTALHLAAENDY 278
            .|.:||:.||:.|.......:|||.|:..|..:...:||.|||| ::...:...|.||||::...
Worm   506 IVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNAD-KTLLTKKGFTPLHLASKYGN 569

  Fly   279 VECARLLLEHRAEVDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALHAAIVKQ 343
            :|..|||||....||....:..||||:|....:.....||:..||:..|..::|.|.||.|..|
Worm   570 LEVVRLLLERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKK- 633

  Fly   344 SRSLDCCNALLKAGADVNKADNYGYTPLHIAALNEFSSCVYTFIEHGADITARTDGRVSALSFIV 408
             ..::..:.||:..||.|.....|:||||::|...........||:|:|:.|:.:..::|:....
Worm   634 -NQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCA 697

  Fly   409 RRTPEIIPKLMQKLDSSIKANDQEIGDVDCQIKLDFRLLVPSSSMDRGETELLLSLIE----VGQ 469
            :.....:.:::....:.|.:. ...|.....:...|           |:..::..|:|    ||:
Worm   698 QEDHVPVAQILYNNGAEINSK-TNAGYTPLHVACHF-----------GQLNMVKFLVENGADVGE 750

  Fly   470 K 470
            |
Worm   751 K 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365	13/34 (38%)
		ANK repeat	102..130	CDD:293786	6/11 (55%)
		ANK	127..252	CDD:238125	39/158 (25%)
		ANK repeat	132..163	CDD:293786	12/63 (19%)
		Ank_2	137..226	CDD:289560	29/122 (24%)
		ANK repeat	166..196	CDD:293786	9/30 (30%)
		ANK	198..319	CDD:238125	41/120 (34%)
		ANK repeat	200..229	CDD:293786	10/28 (36%)
		Ank_2	203..296	CDD:289560	34/92 (37%)
		ANK repeat	231..262	CDD:293786	11/30 (37%)
		ANK	268..387	CDD:238125	40/118 (34%)
		ANK repeat	268..296	CDD:293786	13/27 (48%)
		Ank_2	270..364	CDD:289560	33/93 (35%)
		ANK repeat	298..329	CDD:293786	10/30 (33%)
		ANK repeat	331..364	CDD:293786	11/32 (34%)
		Ank_5	353..404	CDD:290568	16/50 (32%)
		ANK repeat	366..396	CDD:293786	10/29 (34%)
		Ion_trans	556..734	CDD:278921
unc-44	NP_001367345.1	ANK repeat	32..63	CDD:293786
		PHA03095	37..>387	CDD:222980	5/9 (56%)
		ANK repeat	65..96	CDD:293786
		ANK repeat	98..129	CDD:293786
		ANK repeat	131..156	CDD:293786
		ANK repeat	197..224	CDD:293786
		ANK repeat	226..257	CDD:293786
		PHA02876	<242..>648	CDD:165207	81/274 (30%)
		ANK repeat	259..290	CDD:293786
		ANK repeat	292..322	CDD:293786
		ANK repeat	325..356	CDD:293786
		ANK repeat	358..389	CDD:293786	6/11 (55%)
		ANK repeat	391..422	CDD:293786	9/30 (30%)
		ANK repeat	424..455	CDD:293786	3/30 (10%)
		ANK repeat	457..488	CDD:293786	10/31 (32%)
		ANK repeat	490..519	CDD:293786	10/28 (36%)
		ANK repeat	523..552	CDD:293786	11/29 (38%)
		Ank_2	555..>780	CDD:423045	55/211 (26%)
		ANK repeat	556..586	CDD:293786	13/29 (45%)
		ANK repeat	589..620	CDD:293786	10/30 (33%)
		ANK repeat	622..652	CDD:293786	11/31 (35%)
		ANK repeat	655..685	CDD:293786	10/29 (34%)
		ANK repeat	688..719	CDD:293786	2/31 (6%)
		ANK repeat	721..752	CDD:293786	8/42 (19%)
		ANK repeat	754..784	CDD:293786
		Ank_4	756..807	CDD:372654
		ZU5	1008..1110	CDD:128514
		UPA_2	1337..1472	CDD:375346
		Death_ank	1503..1580	CDD:260029
		PTZ00449	<1770..2112	CDD:185628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940