DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyx and ASB12

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_569059.3	Gene:	ASB12 / 142689	HGNCID:	19763	Length:	318	Species:	Homo sapiens

Alignment Length:	188	Identity:	57/188 - (30%)
Similarity:	85/188 - (45%)	Gaps:	43/188 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 TSLHCAASSKSVECILLLLRRKASI-NIGIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYT 232
            |.|..|||...:.|:.:||...|.: ::.::.::.|..|:....:|||.:||:.||.|. ..:|.
Human    75 TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG-GSIYN 138

  Fly   233 E-TPLHTASAAGFAKCVQLLLSHNADVRSQFGEGKVTA---------------LHLAAENDYVEC 281
            . :|:.||:..|....:|.||.|.|       |..|.|               |:|||...:::|
Human   139 NCSPVLTAARDGAVAILQELLDHGA-------EANVKAKLPVWASNIASCSGPLYLAAVYGHLDC 196

  Fly   282 ARLLLEHRAEVDCRNASHQ-----TP---------LHLACLSQSIGTVDLLISYGANV 325
            .||||.|.|:.| .|.:.|     .|         ||..|..:.|   .|||.:|||:
Human   197 FRLLLLHGADPD-YNCTDQGLLARVPRPRTLLEICLHHNCEPEYI---QLLIDFGANI 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365
		ANK repeat	102..130	CDD:293786
		ANK	127..252	CDD:238125	25/84 (30%)
		ANK repeat	132..163	CDD:293786
		Ank_2	137..226	CDD:289560	18/57 (32%)
		ANK repeat	166..196	CDD:293786	9/27 (33%)
		ANK	198..319	CDD:238125	43/150 (29%)
		ANK repeat	200..229	CDD:293786	10/28 (36%)
		Ank_2	203..296	CDD:289560	35/108 (32%)
		ANK repeat	231..262	CDD:293786	10/31 (32%)
		ANK	268..387	CDD:238125	26/87 (30%)
		ANK repeat	268..296	CDD:293786	13/42 (31%)
		Ank_2	270..364	CDD:289560	25/70 (36%)
		ANK repeat	298..329	CDD:293786	12/42 (29%)
		ANK repeat	331..364	CDD:293786
		Ank_5	353..404	CDD:290568
		ANK repeat	366..396	CDD:293786
		Ion_trans	556..734	CDD:278921
ASB12	NP_569059.3	Ank_2	8..103	CDD:289560	9/27 (33%)
		ANK	75..201	CDD:238125	39/133 (29%)
		ANK repeat	75..103	CDD:293786	9/27 (33%)
		Ank_2	77..168	CDD:289560	29/98 (30%)
		ANK repeat	105..136	CDD:293786	10/31 (32%)
		ANK repeat	138..168	CDD:293786	10/36 (28%)
		ANK repeat	182..208	CDD:293786	11/25 (44%)
		ANK	184..>250	CDD:238125	24/69 (35%)
		Ank_2	185..>250	CDD:289560	24/68 (35%)
		SOCS_box	277..315	CDD:284857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000