DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyx and Ank1

DIOPT Version :9

Sequence 1:NP_612015.1 Gene:pyx / 38037 FlyBaseID:FBgn0035113 Length:956 Species:Drosophila melanogaster
Sequence 2:XP_006509052.1 Gene:Ank1 / 11733 MGIID:88024 Length:1950 Species:Mus musculus


Alignment Length:607 Identity:146/607 - (24%)
Similarity:220/607 - (36%) Gaps:171/607 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 KHVVDMVQSGCFLELMTDSADCNLALICCSVFGSVENTLFLLKHYNADPNVADSRGRTPLHFACC 142
            |.||:::.....||..|...  |.||...::.|. :..:..|.:|.|:.|....:|.|||:.|..
Mouse   110 KMVVELLHKEIILETTTKKG--NTALHIAALAGQ-DEVVRELVNYGANVNAQSQKGFTPLYMAAQ 171

  Fly   143 RANAPIAKVLLDFGADPN----------------------------------------------- 160
            ..:..:.|.||:.||:.|                                               
Mouse   172 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 236

  Fly   161 --------RWDARKEV------TSLHCAASSKSVECILLLLRRKASINI----GIEKRSALHYAI 207
                    :.|...:|      |.||.||..:::....|||.|.||:|.    ||   :.||.|.
Mouse   237 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---TPLHIAS 298

  Fly   208 DVNAVDCVEILLKYGADPNTPQVYTETPLHTASAAGFAKCVQLLLSHNADVRSQFGEGKVTALHL 272
            ....|..|.:||..||...|......||||.|:..|..:..::||.|.|.::::...| ::.:|:
Mouse   299 RRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSPIHM 362

  Fly   273 AAENDYVECARLLLEHRAEVDCRNASHQTPLHLACLSQSIGTVDLLISYGANVNAVYRDGRTALH 337
            ||:.|:::|.||||::.||:|.....|.||||:|..........:|:..||..|:...:|.|.||
Mouse   363 AAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 427

  Fly   338 AAIVKQSRSLDCCNALLKAGADVNKADNYGYTPLHIAALNEFSSCVYTFIEHGADITARTDGRVS 402
            .|..|  ..:.....|||.||.::.....|.||||:|:.......|...::.||.         .
Mouse   428 IACKK--NHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS---------P 481

  Fly   403 ALSFIVRRTP----------EIIPKLMQ-KLDSSIKANDQEIGDVDCQIKLDFRLLVPSSSMDRG 456
            .:|.:...||          |:...|:| |..::.||.|.:. .:.|..::             |
Mouse   482 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQT-PLHCAARI-------------G 532

  Fly   457 ETELLLSLIEVGQKRILMHPLCETFLFLKWRRIRKFFLMSLAYHTLFVILFTFYVIWVYVRCCKK 521
            .|.::..|:|.|....|......|.|                 ||                    
Mouse   533 HTGMVKLLLENGASPNLATTAGHTPL-----------------HT-------------------- 560

  Fly   522 EELCVAPGYVSTIGYLVIILNLILLGKEVFQMAHGLRGY------AKYWENWLQWTIGTGVLLC- 579
               ....|:|.|.        |.||.||..|.....:|:      |||.:      :....||. 
Mouse   561 ---AAREGHVDTA--------LALLEKEASQACMTKKGFTPLHVAAKYGK------VRLAELLLE 608

  Fly   580 --VTPETVRTDDLTAVPVWQHH 599
              ..|.....:.||.:.|..||
Mouse   609 HDAHPNAAGKNGLTPLHVAVHH 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pyxNP_612015.1 Ank_4 99..153 CDD:290365 14/53 (26%)
ANK repeat 102..130 CDD:293786 7/27 (26%)
ANK 127..252 CDD:238125 44/189 (23%)
ANK repeat 132..163 CDD:293786 11/85 (13%)
Ank_2 137..226 CDD:289560 33/153 (22%)
ANK repeat 166..196 CDD:293786 13/39 (33%)
ANK 198..319 CDD:238125 39/120 (33%)
ANK repeat 200..229 CDD:293786 10/28 (36%)
Ank_2 203..296 CDD:289560 33/92 (36%)
ANK repeat 231..262 CDD:293786 10/30 (33%)
ANK 268..387 CDD:238125 40/118 (34%)
ANK repeat 268..296 CDD:293786 12/27 (44%)
Ank_2 270..364 CDD:289560 33/93 (35%)
ANK repeat 298..329 CDD:293786 10/30 (33%)
ANK repeat 331..364 CDD:293786 11/32 (34%)
Ank_5 353..404 CDD:290568 14/50 (28%)
ANK repeat 366..396 CDD:293786 9/29 (31%)
Ion_trans 556..734 CDD:278921 12/53 (23%)
Ank1XP_006509052.1 ANK repeat 454..485 CDD:293786 9/39 (23%)
ANK repeat 487..518 CDD:293786 6/30 (20%)
ANK repeat 520..549 CDD:293786 7/42 (17%)
ANK repeat 554..584 CDD:293786 13/77 (17%)
ANK repeat 586..617 CDD:293786 7/36 (19%)
Ank_2 597..>810 CDD:393464 9/40 (23%)
ANK repeat 619..647 CDD:293786 5/12 (42%)
ANK repeat 652..682 CDD:293786
ANK repeat 685..716 CDD:293786
ANK repeat 718..749 CDD:293786
ANK repeat 751..782 CDD:293786
ANK repeat 784..812 CDD:293786
Ank_4 785..837 CDD:372654
ZU5 970..1074 CDD:128514
UPA_2 1295..1424 CDD:375346
Death_ank1 1460..1543 CDD:260067
ANK repeat 65..93 CDD:293786
Ank_2 67..158 CDD:372319 14/50 (28%)
ANK repeat 95..126 CDD:293786 5/15 (33%)
ANK repeat 129..159 CDD:293786 8/32 (25%)
PHA02876 <141..>486 CDD:165207 95/360 (26%)
ANK repeat 161..192 CDD:293786 11/30 (37%)
ANK repeat 194..218 CDD:293786 0/23 (0%)
ANK repeat 227..254 CDD:293786 2/26 (8%)
ANK repeat 257..287 CDD:293786 12/29 (41%)
ANK repeat 289..320 CDD:293786 12/33 (36%)
ANK repeat 322..353 CDD:293786 10/30 (33%)
ANK repeat 355..386 CDD:293786 13/31 (42%)
ANK repeat 391..419 CDD:293786 9/27 (33%)
ANK repeat 421..452 CDD:293786 11/32 (34%)
PHA02875 433..>643 CDD:165206 56/275 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.030

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