DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyx and Ank2

DIOPT Version :9

Sequence 1:NP_612015.1 Gene:pyx / 38037 FlyBaseID:FBgn0035113 Length:956 Species:Drosophila melanogaster
Sequence 2:XP_036018747.1 Gene:Ank2 / 109676 MGIID:88025 Length:4152 Species:Mus musculus


Alignment Length:372 Identity:112/372 - (30%)
Similarity:169/372 - (45%) Gaps:30/372 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 SVFGSVENTLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVLLDFGADPNRWDARKEVTSL 171
            |..|..|....||:|. |.|:.|.:.|.||||.:.......:|.|||:.|| .:....:|..|.|
Mouse   522 SRLGKTEIVQLLLQHM-AHPDAATTNGYTPLHISAREGQVDVASVLLEAGA-AHSLATKKGFTPL 584

  Fly   172 HCAASSKSVECILLLLRRKASI-NIGIEKRSALHYAIDVNAVDCVEILLKYGADPNTPQVYTETP 235
            |.||...|::...|||:|:|:. :.|....:.||.|...:......:||:.||.|:.......||
Mouse   585 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 649

  Fly   236 LHTASAAGFAKCVQLLLSHNADVRSQFGEGKVTALHLAAENDYVECARLLLEHRAEVDCRNASHQ 300
            ||.|:.....:....||::.|:..:...:| ||.||||::..:.:...|||:..|.:.....|..
Mouse   650 LHIAAKKNQMQIASTLLNYGAETNTVTKQG-VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 713

  Fly   301 TPLHLACLSQSIGTVDLLISYGANVNAVYRDGRT----ALHAAIVKQSRSLDCCNALLKAGADVN 361
            |.||||.....:...|:|..:||:.:|..:.|.|    |.|...||.      .|.|||.||:||
Mouse   714 TSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKM------VNFLLKQGANVN 772

  Fly   362 KADNYGYTPLHIAALNEFSSCVYTFIEHGADITARTDGRVSALSFIVRRTPEIIPKLMQKLDSSI 426
            .....||||||.||....:..:...::|||...|.|....:||: |.:|...|      .:..::
Mouse   773 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA-IAKRLGYI------SVVDTL 830

  Fly   427 KANDQEIGDVDCQIKLDFRLLVPSSSMDRGETELLLSLIEVGQKRIL 473
            |...:|:......|....:|.||         |.:..:::|..:..|
Mouse   831 KVVTEEVTTTTTTITEKHKLNVP---------ETMTEVLDVSDEEAL 868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pyxNP_612015.1 Ank_4 99..153 CDD:290365 16/45 (36%)
ANK repeat 102..130 CDD:293786 8/22 (36%)
ANK 127..252 CDD:238125 38/125 (30%)
ANK repeat 132..163 CDD:293786 11/30 (37%)
Ank_2 137..226 CDD:289560 28/89 (31%)
ANK repeat 166..196 CDD:293786 12/30 (40%)
ANK 198..319 CDD:238125 34/120 (28%)
ANK repeat 200..229 CDD:293786 8/28 (29%)
Ank_2 203..296 CDD:289560 27/92 (29%)
ANK repeat 231..262 CDD:293786 8/30 (27%)
ANK 268..387 CDD:238125 42/122 (34%)
ANK repeat 268..296 CDD:293786 9/27 (33%)
Ank_2 270..364 CDD:289560 33/97 (34%)
ANK repeat 298..329 CDD:293786 11/30 (37%)
ANK repeat 331..364 CDD:293786 14/36 (39%)
Ank_5 353..404 CDD:290568 20/50 (40%)
ANK repeat 366..396 CDD:293786 11/29 (38%)
Ion_trans 556..734 CDD:278921
Ank2XP_036018747.1 PHA03095 46..>354 CDD:222980
ANK repeat 80..111 CDD:293786
ANK repeat 113..144 CDD:293786
ANK repeat 146..171 CDD:293786
Ank_2 202..>444 CDD:423045
ANK repeat 212..247 CDD:293786
ANK repeat 249..280 CDD:293786
ANK repeat 282..313 CDD:293786
ANK repeat 315..345 CDD:293786
ANK repeat 348..379 CDD:293786
ANK repeat 381..411 CDD:293786
ANK repeat 414..445 CDD:293786
PHA03095 421..>706 CDD:222980 60/186 (32%)
ANK repeat 447..478 CDD:293786
ANK repeat 480..511 CDD:293786
ANK repeat 513..542 CDD:293786 8/20 (40%)
ANK repeat 546..571 CDD:293786 9/24 (38%)
Ank_2 578..>802 CDD:423045 74/230 (32%)
ANK repeat 579..604 CDD:293786 11/24 (46%)
ANK repeat 612..643 CDD:293786 8/30 (27%)
ANK repeat 645..676 CDD:293786 8/30 (27%)
ANK repeat 678..707 CDD:293786 11/29 (38%)
ANK repeat 711..742 CDD:293786 11/30 (37%)
ANK repeat 744..775 CDD:293786 14/36 (39%)
ANK repeat 777..806 CDD:293786 11/28 (39%)
Ank_4 778..830 CDD:372654 18/58 (31%)
ZU5 1013..1150 CDD:128514
UPA_2 1371..1500 CDD:375346
PHA03307 1823..>2031 CDD:223039
PTZ00449 <2261..2668 CDD:185628
COG5665 <2758..>2989 CDD:227952
PHA03307 3210..>3537 CDD:223039
Death_ank2 3595..3678 CDD:260066
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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