DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyx and trpa1

DIOPT Version :9

Sequence 1:	NP_612015.1	Gene:	pyx / 38037	FlyBaseID:	FBgn0035113	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001121434.1	Gene:	trpa1 / 100158526	XenbaseID:	XB-GENE-1004945	Length:	1144	Species:	Xenopus tropicalis

Alignment Length:	961	Identity:	208/961 - (21%)
Similarity:	342/961 - (35%)	Gaps:	308/961 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 DCNLALICCSVFGSVEN-----------TLF-------LLKHYNADPNVADSRGRTPLHFACCRA 144
            ||...|:|.....:::|           .||       |:.|...|.|:....|.||:..|||:.
Frog   118 DCLKVLLCRGADPNIQNCYRLSPLHLAIQLFHNSIAEALILHSTTDINLEGDLGNTPVMQACCKD 182

  Fly   145 NAPIAKVLLDFGADPNRWDARKEVTSLHCAASSKSVECILLLLRRKASINIGI---------EKR 200
            |.....:||..||...:.: :.....:|..|...|::|:.::|::...:...|         ||.
Frog   183 NHEALNLLLGRGAKLCKQN-KLGCYPIHMTAFMGSLKCMDIILKKGEEMGYTIDHHINFTNNEKS 246

  Fly   201 SALHYAIDVNAVDCVEILLKYGADPNTPQVYTETPLHTASAAGFAKCVQLLLSHNADVRSQFGEG 265
            |.||.|:....:|.|:..:.|||..:..|....|.||.|:..|..:.|:.::|..:|      :.
Frog   247 SPLHLAVQNGNIDVVKACISYGAKIDLRQSDNATALHFAATQGATEIVKFMVSSYSD------DN 305

  Fly   266 KV---------TALHLAAENDYVECARLLLEHRAEVDCRNASHQTPLHLACLSQSIGTVDLLISY 321
            |:         |.||.:...|:||.|..|:...|.:|..:...:|||.||....:..:|:||:|.
Frog   306 KIVDLPDGNDETPLHKSVLFDHVELAEYLISEGANIDSEDKESRTPLLLATSCSAWKSVNLLLSK 370

  Fly   322 GANVNAVYRDGRTALHAAIV--------------------------------------------- 341
            ||:|......||..||..::
Frog   371 GADVKLKDHYGRNFLHLMVLQPGGLKNLNSEFLQMENIKKLVSDEDCEGCTPLHYACRHGVPNSV 435

  Fly   342 --------------KQSRS----------LDCCNALLKAGAD---VNKADNYGYTPLHIAALNEF 379
                          |..||          .:.|..||:..:|   :|..|..|.||||:||.|..
Frog   436 NNLLGLNMSLYSKSKNKRSPLHFAACYGRFNTCQRLLRFMSDGRLLNDGDEKGMTPLHLAAENGH 500

  Fly   380 SSCVYTFIEHGA-----------------------------------DIT----------ARTDG 399
            ...|:..::.||                                   |.|          |..:|
Frog   501 EKIVFLLLKRGALLLSDHRGWTALHYAALSGYTRTIKTLLETSIGLIDKTDKEQNTAMHLAGREG 565

  Fly   400 RVSALSFIV----------------------------------RRTPEI-------------IPK 417
            ...|:|.::                                  .|..||             |.:
Frog   566 HAKAVSLLLENGASILLNANGASYIHEAIRFGKKDTVLVSIQSERWEEILQTFSHTSSYKCAILE 630

  Fly   418 LMQKLDSSIK-----ANDQEIGD---VDCQIKLDFRLL-VPSSSMDRGETE---------LLLSL 464
            ::..|..|.|     ...:.|||   .|..::.:|..| .|.|.....:.|         .|.::
Frog   631 MIYHLPESFKTLLDRCMTESIGDKKSPDFHVEYNFTYLQCPLSFRKAHKRENNVHYEPLTTLNAM 695

  Fly   465 IEVGQKRILMHPLCETFLFLKWRRIR-KFFLMSLAYHTLFVILFTFYVIWVYVRCCKKEELCVA- 527
            ::..:..:|.||:|:.:|.:||.... |..|::||.::|.:|..|..:|    ...:.|.|.:.
Frog   696 VQHQRIDLLSHPVCKEYLLMKWMAYGFKAHLLNLAIYSLGLIPLTLLII----NAVRPESLAIIE 756

  Fly   528 ---------------------------------PGYVSTIGYLVIILNLILLGKEVFQMAHGLRG 559
                                             ..|......||..::|..:.||..|:......
Frog   757 ECEHLKRTDFYNSSMKQECANVSRKLDLLQLKDTQYTRVCMGLVFCMSLFGIVKEAVQLCQQKLA 821

  Fly   560 YAKYWENWLQWTIGTGVLLCVTPETVRTDDLTAVPV------WQHHVAAIVILLVWLELMMLVGR 618
            |.....|.:.|:|....::.|:       .|...|:      ||  ..||.:...|:..::.:.|
Frog   822 YIGDGSNIIDWSIYISSIIFVS-------SLCHSPIVVSGLQWQ--FGAIAVFASWVNFLIYLQR 877

  Fly   619 FPIFGVYVQMFTKVAVNFAKFLLAYICLLVAFGLSFAVLFNDYPAFENITWSFLKSITMMSGELE 683
            |..:|:|:.||.::.....:.:..:..|::||||||.|.......|....::.::|.|||.|::.
Frog   878 FESYGIYIVMFWEILRTLLRIVFLFFFLILAFGLSFYVFLYPQVTFSRPYFALMQSFTMMLGDIN 942

  Fly   684 FEDIFYG---DYAVKFPVTAHIIFLSFVLLVTVILTNLMVGLAVSDIQGLQVSATLDRLVRQAEL 745
            :|:.|..   |..:::|....|..:.|.||:.::|.||::||||.||..:|.:|.|.|:..|..|
Frog   943 YEEGFLKPLLDDQIEYPFFTFIHLIMFTLLIPILLMNLLIGLAVGDIAEVQRNACLKRIAMQVSL 1007

  Fly   746 VSRLES----LFFSRLLRSAPTNLIQLCKRSALLRTSRDKLQFTIRPNDPR 792
            .:.||.    .|..|:                      ||:..|:.||.||
Frog  1008 HTSLEKKLPFWFLKRV----------------------DKISITVYPNRPR 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyx	NP_612015.1	Ank_4	99..153	CDD:290365	17/71 (24%)
		ANK repeat	102..130	CDD:293786	9/45 (20%)
		ANK	127..252	CDD:238125	36/133 (27%)
		ANK repeat	132..163	CDD:293786	11/30 (37%)
		Ank_2	137..226	CDD:289560	25/97 (26%)
		ANK repeat	166..196	CDD:293786	5/29 (17%)
		ANK	198..319	CDD:238125	38/129 (29%)
		ANK repeat	200..229	CDD:293786	9/28 (32%)
		Ank_2	203..296	CDD:289560	28/101 (28%)
		ANK repeat	231..262	CDD:293786	8/30 (27%)
		ANK	268..387	CDD:238125	44/190 (23%)
		ANK repeat	268..296	CDD:293786	10/27 (37%)
		Ank_2	270..364	CDD:289560	33/165 (20%)
		ANK repeat	298..329	CDD:293786	12/30 (40%)
		ANK repeat	331..364	CDD:293786	12/104 (12%)
		Ank_5	353..404	CDD:290568	20/98 (20%)
		ANK repeat	366..396	CDD:293786	13/74 (18%)
		Ion_trans	556..734	CDD:278921	50/186 (27%)
trpa1	NP_001121434.1	Ank_2	43..134	CDD:289560	4/15 (27%)
		ANK repeat	68..101	CDD:293786
		ANK	98..224	CDD:238125	26/106 (25%)
		ANK repeat	103..134	CDD:293786	4/15 (27%)
		Ank_2	108..201	CDD:289560	22/82 (27%)
		ANK repeat	136..168	CDD:293786	6/31 (19%)
		ANK repeat	170..201	CDD:293786	11/30 (37%)
		ANK repeat	203..242	CDD:293786	6/38 (16%)
		ANK	239..368	CDD:238125	38/134 (28%)
		ANK repeat	247..275	CDD:293786	9/27 (33%)
		Ank_2	249..345	CDD:289560	28/101 (28%)
		ANK repeat	277..312	CDD:293786	9/40 (23%)
		ANK repeat	314..345	CDD:293786	10/30 (33%)
		Ank_5	334..387	CDD:290568	18/52 (35%)
		ANK repeat	347..378	CDD:293786	12/30 (40%)
		Ank_4	421..472	CDD:290365	4/50 (8%)
		ANK	447..574	CDD:238125	26/126 (21%)
		ANK repeat	451..485	CDD:293786	7/33 (21%)
		ANK repeat	490..517	CDD:293786	10/26 (38%)
		Ank_2	492..583	CDD:289560	14/90 (16%)
		ANK repeat	519..551	CDD:293786	1/31 (3%)
		ANK repeat	553..578	CDD:293786	4/24 (17%)
		Ion_trans	820..996	CDD:278921	50/184 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D180347at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920