Protein Alignment Dis3l2 and SSD1

DIOPT Version :10

• Sequence 1: NP_728490.1
• Gene: Dis3l2 / 38034
• FlyBaseID: FBgn0035111
• Length: 1044
• Species: Drosophila melanogaster
• Sequence 2: NP_010579.1
• Gene: SSD1 / 851887
• SGDID: S000002701
• Length: 1250
• Species: Saccharomyces cerevisiae
• Alignment Length: 1201
• Identity: 253/1201 - (21%)
• Similarity: 468/1201 - (38%)
• Gaps: 287/1201 - (23%)

  Fly     2 PYPLYPAHSQVMSETSSVNVDADRDCRRIEGLRQRSQRLAARLQQMQRE----MESNASSKDLSA 62
            |..::.||.:..||.:::.::.....:::|.::.:.|:|.|:.||:.::    :..|:.|
Yeast    30 PKQIHVAHRRSQSELTNLMIEQFTLQKQLEQVQAQQQQLMAQQQQLAQQTGQYLSGNSGS----- 89

  Fly    63 NNAVIPLQPLMRWAEPRPHPNQSQPS---------ARSNSRQAIPYGVPVSTPAPVAMQLPYHVA 118
            ||...| ||      |.||.|.:..|         :|::||....|               ||.:
Yeast    90 NNHFTP-QP------PHPHYNSNGNSPGMSAGGSRSRTHSRNNSGY---------------YHNS 132

  Fly   119 FASYQATMQIPCLQPLSHLHVVSSPSHRLIAKKKSKRALRNEVE--ALQDMVKHLSHLSPDVNAY 181
            :.:...:.     .|.|:.|..:|....:....:......||.:  |.::..|.:|.....|...
Yeast   133 YDNNNNSN-----NPGSNSHRKTSSQSSIYGHSRRHSLGLNEAKKAAAEEQAKRISGGEAGVTVK 192

  Fly   182 ACQLIRKNEILSQLEWSQTRSEAHPQQVGYQGRHR-------------------HDSEVSATNNG 227
            ...:...:...|..|.|..:....|.  .:||..|                   :|.|..||::
Yeast   193 IDSVQADSGSNSTTEQSDFKFPPPPN--AHQGHRRATSNLSPPSFKFPPNSHGDNDDEFIATSS- 254

  Fly   228 SHVQQQPKLGRRQRNSKKNDGSGSNGTQSQKTELEAMRSYINKIVQRHVGMD-------HQLSED 285
            :|.:.      :.||::.:.|..||.....:...:.:..:      ||.|.:       :.|...
Yeast   255 THRRS------KTRNNEYSPGINSNWRNQSQQPQQQLSPF------RHRGSNSRDYNSFNTLEPP 307

  Fly   286 LIF----KGNFSDLEAHA-----------QRLVAAGY------------GRIVEEEIRVNRKNNR 323
            .||    |...|:...|:           ::.:.|.|            ||:|...:|||:||..
Yeast   308 AIFQQGHKHRASNSSVHSFSSQGNNNGGGRKSLFAPYLPQANIPELIQEGRLVAGILRVNKKNRS 372

  Fly   324 QAFIIMSTDREALERDGIVLLPVARRYAFDGDKVRAFVL-------------------------- 362
            .|::  ||| .||:.|..:.....|..|.:||.|...:|
Yeast   373 DAWV--STD-GALDADIYICGSKDRNRALEGDLVAVELLVVDDVWESKKEKEEKKRRKDASMQHD 434

  Fly   363 -------NPGAQGSSKTAEPSSGEISGGKPSLSLA----------------DGEELSDDTES--- 401
                   :.....:|.||..|:..:|....|.||:                |.:.||..|:|
Yeast   435 LIPLNSSDDYHNDASVTAATSNNFLSSPSSSDSLSKDDLSVRRKRSSTINNDSDSLSSPTKSGVR 499

  Fly   402 -------QGSESDTDNVVV------------ISSDNCP--KAFVIAITKRTELRQIVGTISFTNP 445
                   :.::...|:|.|            |:....|  ...|:|:..|...:...||:....|
Yeast   500 RRSSLKQRPTQKKNDDVEVEGQSLLLVEEEEINDKYKPLYAGHVVAVLDRIPGQLFSGTLGLLRP 564

  Fly   446 TKLCDDQ--------LFYKFRPYDLRVPMVYVPKD-ACAAHIGNKQQIDVSGLLYLAHILETDCN 501
            ::..:..        ....|:|.|.:||::.:|.: |....:.|..:  .|..|::|.|......
Yeast   565 SQQANSDNNKPPQSPKIAWFKPTDKKVPLIAIPTELAPKDFVENADK--YSEKLFVASIKRWPIT 627

  Fly   502 G-HCIAELIQPVGRVGNLDDELKAILFHNGLRDIKPFEQRFIDIYSQP--------PPPISQEDL 557
            . |....|:..:|.:.:.|.|:.:|     |||.......::| ...|        |.|::.|.|
Yeast   628 SLHPFGILVSELGDIHDPDTEIDSI-----LRDNNFLSNEYLD-QKNPQKEKPSFQPLPLTAESL 686

  Fly   558 RQRK---DLRKMCIFTIDPMTARDLDDAVSIEKLGDNEYEIGVHISDVSHFLIEDNELDNIVKER 619
            ..|:   |..:..||.|..: ....:.|:.:...|:...|:|.|:.||:..:.|.:.:|...::|
Yeast   687 EYRRNFTDTNEYNIFAISEL-GWVSEFALHVRNNGNGTLELGCHVVDVTSHIEEGSSVDRRARKR 750

  Fly   620 STSIYLANEVIHMLPQSLCMRCSLLPGQDKFAFSVFWRMNGKGVMLQKKPEFCRTVINSCSQFAY 684
            |:::::..:::::||||.....||.||::....||.:.::...:.: |......:.|:..:..:.
Yeast   751 SSAVFMPQKLVNLLPQSFNDELSLAPGKESATLSVVYTLDSSTLRI-KSTWVGESTISPSNILSL 814

  Fly   685 EHAQKIIDNPNERFTENDFPTILNGFNPDDIRNRVLWLHDIASSIRKTRLDNGALT--------- 740
            |...:.:...:        ||           :.:..:.:||.|....|:::...|
Yeast   815 EQLDEKLSTGS--------PT-----------SYLSTVQEIARSFYARRINDPEATLLPTLSLLE 860

  Fly   741 -INNAKLRFLLDPITGEPLSFEVEKQREANRLIEEFMLLANQAVARFIHDSFPDIAVLRNHPPPL 804
             :::.|::..|: |....|.|.|         |.|.....|..||..|:....|:|:||....|:
Yeast   861 SLDDEKVKVDLN-ILDRTLGFVV---------INEIKRKVNSTVAEKIYTKLGDLALLRRQMQPI 915

  Fly   805 IKSLKALREKLLALGFELDYSSSKALQESMVRLCNEAPNPVAMNACLSQLLMKPMARATYFCSEG 869
            ...:.:.|:|:...|:..|.:::..|.:.::::.::     .:...:..||.|.|.||.||.: |
Yeast   916 ATKMASFRKKIQNFGYNFDTNTADELIKGVLKIKDD-----DVRVGIEILLFKTMPRARYFIA-G 974

  Fly   870 KSEPADLWHYALSIPIYTHFTSPIRRYPDILVHRLLAAALKYCTPPKRTPDDLHTLTKLANERKY 934
            |.:|....||||::|||||||:|:|||.|.:|||.|.|.: :.||.....:.|...::..|.:|.
Yeast   975 KVDPDQYGHYALNLPIYTHFTAPMRRYADHVVHRQLKAVI-HDTPYTEDMEALKITSEYCNFKKD 1038

  Fly   935 NAKKAGEDSGNLYFKRYVH---NKQG-IYMRAVVIEIFQHMMNVVTLESG-----H-----VISI 985
            .|.:|.|.:.:|...:.::   |..| :...|.|:::::...:|...|.|     |     :|..
Yeast  1039 CAYQAQEQAIHLLLCKTINDMGNTTGQLLTMATVLQVYESSFDVFIPEFGIEKRVHGDQLPLIKA 1103

  Fly   986 NYKMQKVLVDTHGVP-----NYILIAERNLK 1011
            .:.....:::.|..|     .:|...|:|.|
Yeast  1104 EFDGTNRVLELHWQPGVDSATFIPADEKNPK 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3l2	NP_728490.1	OB_Dis3	454..530	CDD:436091	18/77 (23%)
		RNB	560..909	CDD:459934	90/361 (25%)
SSD1	NP_010579.1	OB_Dis3	582..657	CDD:436091	21/81 (26%)
		RNB	689..1014	CDD:459934	90/361 (25%)
		Dis3l2_C_term	1064..1151	CDD:465547	14/71 (20%)