Protein Alignment Dis3l2 and Dis3

DIOPT Version :10

• Sequence 1: NP_728490.1
• Gene: Dis3l2 / 38034
• FlyBaseID: FBgn0035111
• Length: 1044
• Species: Drosophila melanogaster
• Sequence 2: NP_001120955.1
• Gene: Dis3 / 306103
• RGDID: 1304646
• Length: 957
• Species: Rattus norvegicus
• Alignment Length: 916
• Identity: 249/916 - (27%)
• Similarity: 399/916 - (43%)
• Gaps: 170/916 - (18%)

  Fly   173 HLSPDVNAYACQL-------IRKNEILSQLEWSQTRSEAHP------------------------ 206
            :|.||.|....|:       || |.|:.|....:.|:.:.|
  Rat    65 YLLPDTNVLLHQIDVLEDPAIR-NVIVLQTVLQEVRNRSAPIYKRIRDVTNNQEKHFYTFTNEHH 128

  Fly   207 ------QQVGYQGRHRHDS--EVSATNNGSHVQQQPKLGRRQ----RNSKKN------DGSGSNG 253
                  |:.|.....|:|.  .|:|.....|::...: .:.|    .|.|||      :|..:..
  Rat   129 KETYIEQEQGENANDRNDRAIRVAAKWYNEHLKMSAE-NQLQVILITNDKKNKEKAAEEGIPAFT 192

  Fly   254 TQSQKTELEAMRSYINKIVQRHVGMDHQLSEDLIFKGNFSDLEAHAQRLVAAGYGRIVEEEIRVN 318
            .:.....|.|....|:::......|:...|..:||..:. .|....|.:.:..|   ::...|.:
  Rat   193 CEEYVKSLTANPELIDRLACLSDEMNEIESGKIIFSEHL-PLSKLQQGIKSGSY---LQGTFRAS 253

  Fly   319 RKNNRQAFIIMSTDRE---------------ALERD--GIVLLPVARRYAFDGDKVRAFVLNPGA 366
            |:|..:|.:.:..|:|               |:..|  .:.|||
  Rat   254 RENYLEATVWIHGDKEDEKEILIQGLKHLNRAIHEDIVAVELLP--------------------- 297

  Fly   367 QGSSKTAEPSSGEISGGKPSLSLADGEELSDDTESQGSESDTDNVVVISSDNCPKAFVIAITKRT 431
              .|:...||         |:.|.|..:..||.|............|......|...|:.|.||
  Rat   298 --KSQWVAPS---------SVVLHDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGRVVGIIKR- 350

  Fly   432 ELRQIVGTISFTNPTKLCDDQLFYKFRPYDLRVPMVYVPKDACAAHIGNKQQIDVSGLLYLAHIL 496
            ..|...|.:|.::    ..:...:.|.|.|.|:|.:.:.....:|..|.:..:.:.|....:..
  Rat   351 NWRPYCGMLSKSD----IKESRRHLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRY- 410

  Fly   497 ETDCNGHCIAELIQPVGRVGNLDDELKAILFHNGLRDI--KPFEQRFIDIYSQPPPPISQEDLRQ 559
               .|||.:..|    |.||..:.|.:.:|..:   |:  :||.|..:....:.|..|::||::.
  Rat   411 ---PNGHFVKNL----GDVGEKETETEVLLLEH---DVPHQPFSQAVLSFLPKMPWSITEEDMKN 465

  Fly   560 RKDLRKMCIFTIDPMTARDLDDAVSIEKLGDNEYEIGVHISDVSHFLIEDNELDNIVKERSTSIY 624
            |:|||.:|:.::||....|:|||:...:|.:...|:||||:|||||:...|.||.....|.|::|
  Rat   466 REDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNALDQESARRGTTVY 530

  Fly   625 LANEVIHMLPQSLCMR-CSLLPGQDKFAFSVFWRMNGKGVMLQKKPEFCRTVINSCSQFAYEHAQ 688
            |..:.|.|:|:.|... |||....|:.|||..|.||....:|  |..|.::||||.:...|..||
  Rat   531 LCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEIL--KTRFTKSVINSKASLTYAEAQ 593

  Fly   689 KIIDNPNERFTENDFPTILNGFNPDDIRNRVLWLHDIASSIRKTRLDNGALTINNAKLRFLLDPI 753
            ..||:           ..:|    |||...:..|:.:|..:::.|::.||||:::.::||.:|..
  Rat   594 MRIDS-----------AAMN----DDITTSLRGLNKLAKILKRGRIEKGALTLSSPEIRFHMDSE 643

  Fly   754 TGEPLSFEVEKQREANRLIEEFMLLANQAVARFIHDSFPDIAVLRNHPPPLIKSLKALREKLLAL 818
            |.:|:..:.::.||.|.::||||||||.:||:.||:.|.:.|:||.||.|...:.:.|.:...:.
  Rat   644 THDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEVLVKAAKSK 708

  Fly   819 GFELDYSSSKALQESMVRLCNEAPNPVAMNACLSQLLMKPMARATYFCSEGKSEPADLWHYALSI 883
            ..|:...::|:|.:|:.|.  |.|:...:|..|..|..:.|.:|.||||   ...:|..||.|:.
  Rat   709 NLEIRTDTAKSLADSLDRA--ECPDFPYLNTLLRILATRCMMQAVYFCS---GMDSDFHHYGLAS 768

  Fly   884 PIYTHFTSPIRRYPDILVHRLLAAAL-KYCTPPKRTPDDLHTLTKLANERKYNAKKAGEDSGNLY 947
            |||||||||||||.||:||||||.|: ..||.|:.|  |.|.|:.:..              ||.
  Rat   769 PIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELT--DKHKLSDICK--------------NLN 817

  Fly   948 FKRYVHNKQGIYMRAVV---IEIFQHMMNVVTLESGHVISINYKMQKVLVDTHGVPNYILIAERN 1009
            |:   |.......||.|   .::|.....:|: |..:::.:......||:..:|:...:...|::
  Rat   818 FR---HKMAQYAQRASVAFHTQLFFKSKGIVS-EEAYILFVRKNAIVVLIPKYGLEGTVFFEEKD 878

  Fly  1010 LKQSPR 1015
             |..||
  Rat   879 -KPKPR 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3l2	NP_728490.1	OB_Dis3	454..530	CDD:436091	17/75 (23%)
		RNB	560..909	CDD:459934	135/349 (39%)
Dis3	NP_001120955.1	PIN_Rrp44-like	9..196	CDD:350211	25/132 (19%)
		VacB	205..928	CDD:440323	222/774 (29%)