Protein Alignment Dis3l2 and DIS3

DIOPT Version :10

• Sequence 1: NP_728490.1
• Gene: Dis3l2 / 38034
• FlyBaseID: FBgn0035111
• Length: 1044
• Species: Drosophila melanogaster
• Sequence 2: NP_055768.3
• Gene: DIS3 / 22894
• HGNCID: 20604
• Length: 958
• Species: Homo sapiens
• Alignment Length: 943
• Identity: 255/943 - (27%)
• Similarity: 423/943 - (44%)
• Gaps: 178/943 - (18%)

  Fly   173 HLSPDVNAYACQL-------IRKNEILSQLEWSQTRSEAHP------------------------ 206
            :|.||.|....|:       || |.|:.|....:.|:.:.|
Human    65 YLLPDTNVLLHQIDVLEDPAIR-NVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHH 128

  Fly   207 ------QQVGYQGRHRHDS--EVSATNNGSHVQQQPKLGRRQ--------RNSKK--NDGSGSNG 253
                  |:.|.....|:|.  .|:|.....|:::.....:.|        ||.:|  .:|..:..
Human   129 RETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFT 193

  Fly   254 TQSQKTELEAMRSYINKIVQRHVGMDHQLSEDLIFKGNFSDLEAHAQRLVAAGY----------- 307
            .:.....|.|....|:::.        .|||:    ||    |..:.:::.:.:
Human   194 CEEYVKSLTANPELIDRLA--------CLSEE----GN----EIESGKIIFSEHLPLSKLQQGIK 242

  Fly   308 -GRIVEEEIRVNRKNNRQAFIIMSTDREALERDGIVLLPVARRYAFDGDKVRAFVLNPGAQGSSK 371
             |..::...|.:|:|..:|.:.:..|.|  |...|:|..:........:.:.|..|.|    .|:
Human   243 SGTYLQGTFRASRENYLEATVWIHGDNE--ENKEIILQGLKHLNRAVHEDIVAVELLP----KSQ 301

  Fly   372 TAEPSSGEISGGKPSLSLADGEELSDDTESQGSESDTDNVV--VISSDNC-PKAFVIAITKRTEL 433
            ...||         |:.|.|..:..:|.|   .|.:|:.::  .:|.... |...|:.|.|| ..
Human   302 WVAPS---------SVVLHDEGQNEEDVE---KEEETERMLKTAVSEKMLKPTGRVVGIIKR-NW 353

  Fly   434 RQIVGTISFTNPTKLCDDQLFYKFRPYDLRVPMVYVPKDACAAHIGNKQQIDVSGLLYLAHILET 498
            |...|.:|.::    ..:...:.|.|.|.|:|.:.:.....:...|.:..:.:.|....:..
Human   354 RPYCGMLSKSD----IKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRY--- 411

  Fly   499 DCNGHCIAELIQPVGRVGNLDDELKAILFHNGLRDI--KPFEQRFIDIYSQPPPPISQEDLRQRK 561
             .|||.:..|    |.||..:.|.:.:|..:   |:  :||.|..:....:.|..|:::|::.|:
Human   412 -PNGHFVRNL----GDVGEKETETEVLLLEH---DVPHQPFSQAVLSFLPKMPWSITEKDMKNRE 468

  Fly   562 DLRKMCIFTIDPMTARDLDDAVSIEKLGDNEYEIGVHISDVSHFLIEDNELDNIVKERSTSIYLA 626
            |||.:||.::||....|:|||:...:|.:...|:||||:|||||:...|.||.....|.|::||.
Human   469 DLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLC 533

  Fly   627 NEVIHMLPQSLCMR-CSLLPGQDKFAFSVFWRMNGKGVMLQKKPEFCRTVINSCSQFAYEHAQKI 690
            .:.|.|:|:.|... |||....|:.|||..|.||....:|  |.:|.::||||.:...|..||..
Human   534 EKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEIL--KTKFTKSVINSKASLTYAEAQLR 596

  Fly   691 IDNPNERFTENDFPTILNGFNPDDIRNRVLWLHDIASSIRKTRLDNGALTINNAKLRFLLDPITG 755
            ||:.|           :|    |||...:..|:.:|..::|.|::.||||:::.::||.:|..|.
Human   597 IDSAN-----------MN----DDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETH 646

  Fly   756 EPLSFEVEKQREANRLIEEFMLLANQAVARFIHDSFPDIAVLRNHPPPLIKSLKALREKLLALGF 820
            :|:..:.::.||.|.::||||||||.:||:.||:.|.:.|:||.||.|...:.:.|.:...:...
Human   647 DPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNL 711

  Fly   821 ELDYSSSKALQESMVRLCNEAPNPVAMNACLSQLLMKPMARATYFCSEGKSEPADLWHYALSIPI 885
            |:...::|:|.||:.:.  |:|....:|..|..|..:.|.:|.|||| |...  |..||.|:.||
Human   712 EIKTDTAKSLAESLDQA--ESPTFPYLNTLLRILATRCMMQAVYFCS-GMDN--DFHHYGLASPI 771

  Fly   886 YTHFTSPIRRYPDILVHRLLAAAL-KYCTPPKRTPDDLHTLTKLANERKYNAKKAGEDSGNLYFK 949
            |||||||||||.|::||||||.|: ..||.|:.|  |.|.|..:..              ||.|:
Human   772 YTHFTSPIRRYADVIVHRLLAVAIGADCTYPELT--DKHKLADICK--------------NLNFR 820

  Fly   950 RYVHNKQGIYMRAVV---IEIFQHMMNVVTLESGHVISINYKMQKVLVDTHGVPNYILIAERNLK 1011
               |.......||.|   .::|.....:|: |..:::.:......||:..:|:...:...|:: |
Human   821 ---HKMAQYAQRASVAFHTQLFFKSKGIVS-EEAYILFVRKNAIVVLIPKYGLEGTVFFEEKD-K 880

  Fly  1012 QSPRKLQLLSVVPICLIIWDQKLTGFLKMEEQI 1044
            .:|:            :|:|.::.. ||:|:.:
Human   881 PNPQ------------LIYDDEIPS-LKIEDTV 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3l2	NP_728490.1	OB_Dis3	454..530	CDD:436091	16/75 (21%)
		RNB	560..909	CDD:459934	138/349 (40%)
DIS3	NP_055768.3	PIN_Rrp44-like	9..197	CDD:350211	24/132 (18%)
		VacB	206..929	CDD:440323	229/801 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	938..958