Protein Alignment Dis3l2 and dis-3

DIOPT Version :10

• Sequence 1: NP_728490.1
• Gene: Dis3l2 / 38034
• FlyBaseID: FBgn0035111
• Length: 1044
• Species: Drosophila melanogaster
• Sequence 2: NP_501835.2
• Gene: dis-3 / 177875
• WormBaseID: WBGene00001001
• Length: 961
• Species: Caenorhabditis elegans
• Alignment Length: 879
• Identity: 247/879 - (28%)
• Similarity: 394/879 - (44%)
• Gaps: 175/879 - (19%)

  Fly   196 EWSQTRSEAHPQQVGYQGRHRHDSEVSATNNGSHVQQQPKLGRR----QRNSKKNDGSGSNGTQS 256
            |.|:.|.|.|.|.|.|.              ..::|.....|::    |..:.::.|   ||.:.
 Worm   183 EDSKKRMENHYQHVMYL--------------KEYIQNLEDPGKQALLDQMAAYESSG---NGNEK 230

  Fly   257 QKTELEAMRSYINKIVQRHVGMDHQLSEDLIFKGNFSDLEAHAQRLVAAGYGRIVEEEIRVNRKN 321
            |.                   .|..||.|.|.:|..|              |.|......|:|:|
 Worm   231 QI-------------------FDEYLSHDRIMEGIAS--------------GTIKRGNFSVSREN 262

  Fly   322 NRQAFIIMSTDREALERDGIVLLPVARRYAFDGDKVRAFVLNPGAQGSSKTAEPSSGEISGGKPS 386
            .|:|.:|:.....:....|...     ..|.:||.| |..|.|..|.::.            :..
 Worm   263 YREATVIIDDQLTSWFITGNNC-----NRAVNGDTV-AVQLLPEDQWTAP------------EKK 309

  Fly   387 LSLADGEE---LSDDTESQGSESDTDN---------VVVISSDNCPKAFVIAITKRTELRQIVGT 439
            :.|.|.||   .:||..::..|:|.:|         .:.:|:     |.|:.|.|| ..|:..|.
 Worm   310 IRLRDVEEYVKTADDMGNEDEENDDENDEPKAKKSKKMTVST-----AKVVGIIKR-NWREYCGM 368

  Fly   440 ISFTNPTKLCDDQLFYKFRPYDLRVPMVYVPKDACAAHIGNKQQIDVSGLLYLAHILETDCNGHC 504
            : ..:..|.....||.   |.:..:|.:.:..:  .|...::|:|.|:    :.|....  :.:.
 Worm   369 L-LPSTVKGARRHLFC---PAERLIPRIRIETE--QAETLSQQRIVVA----IDHWPRD--SKYP 421

  Fly   505 IAELIQPVGRVGNLDDELKAILFHNGLRDI--KPFEQRFIDIYSQPPPPISQEDLRQ------RK 561
            :...::.:|.:|:.:.|.:.:|..:   ||  .||.:..:|..   |....:.||.:      |.
 Worm   422 LGHYVRSIGEMGSRETENEVLLLEH---DIPHAPFSESVLDCL---PREEWEPDLTENRGPLPRV 480

  Fly   562 DLRKMCIFTIDPMTARDLDDAVSIEKLGDNEYEIGVHISDVSHFLIEDNELDNIVKERSTSIYLA 626
            |||.:.|.::||:...|:|||:..:::|::.:|:||||:||:||:.....:|:....|.|::||.
 Worm   481 DLRDLTICSVDPLGCTDIDDALHCKQIGEDLFEVGVHIADVTHFVRPGTAIDDEAALRGTTVYLC 545

  Fly   627 NEVIHMLPQSLCMR-CSLLPGQDKFAFSVFWRMNGKGVMLQKKPEFCRTVINSCSQFAYEHAQKI 690
            :..|.|||..|... |||...::::|||..|.|.....:...|  :.:::|.|.:...||.||:|
 Worm   546 DRRIDMLPCLLSSNLCSLRGEEERYAFSCIWTMTSSADIQSVK--YHKSLIKSKAALTYEKAQEI 608

  Fly   691 IDNPNERFTENDFPTILNGFNPDDIRNRVLWLHDIASSIRKTRLDNGALTINNAKLRFLLDPITG 755
            ||:|.|   :||....|.|            |..::..:...|..|||||:.::::||.:|..:.
 Worm   609 IDDPKE---QNDVALGLRG------------LMKLSKVLNARRTGNGALTLASSEVRFDMDWESR 658

  Fly   756 EPLSFEVEKQREANRLIEEFMLLANQAVARFIHDSFPDIAVLRNHPPPLIKSLKALREKLLALGF 820
            .|.....::..:.:.::||||||||.:||..|.:.:||.|:||.||.||.:|.|.|.|.....||
 Worm   659 TPKKVMEKQHLDTHSMVEEFMLLANISVAEKILEEYPDCALLRRHPVPLKESYKPLVEAARHRGF 723

  Fly   821 ELDYSSSKALQESMVRLCNEAPNPVAMNACLSQLLMKPMARATYFCSEGKSEPADLWHYALSIPI 885
            |:...|.|.|.:|:.| |.:..||: :|..|..|..:.|.:|.|| |.|........|:.|:..|
 Worm   724 EIIVESGKGLADSLNR-CVDKKNPM-LNRLLRMLTTRCMTQAVYF-SAGTVPVPQYQHFGLACAI 785

  Fly   886 YTHFTSPIRRYPDILVHRLLAAALKYCTPPKRTPDDLHT-------LTKLA---NERKYNAKKAG 940
            |||||||||||.|::||||||||:        ..||:.:       .||:.   |.|...|:.||
 Worm   786 YTHFTSPIRRYADVIVHRLLAAAI--------GADDIQSGLLNQARCTKICTNINYRHKQAQYAG 842

  Fly   941 EDSGNL----YFKRYVHNKQGIYM--RAVVIEIF---QHMMNVVTLE----SGHVISINYKMQK- 991
            ..|..|    |||..|...:|..|  |...|::|   ..:.:::.|:    ||..|.:.....|
 Worm   843 RASVQLNVVRYFKGKVETCEGFVMGVRNNGIQVFVPKYGLESIIVLQTSAASGTTIDVEEMSVKV 907

  Fly   992 ----VLVDTHGVPNYILIAERNLKQSPR-KLQLL 1020
                |:.:...|...|.:.|:| :|.|| :|||:
 Worm   908 NGDVVIKELEPVTVRISVNEKN-QQRPRVELQLI 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3l2	NP_728490.1	OB_Dis3	454..530	CDD:436091	12/75 (16%)
		RNB	560..909	CDD:459934	132/349 (38%)
dis-3	NP_501835.2	PIN_Rrp44-like	20..202	CDD:350211	8/32 (25%)
		Rrp44_CSD1	233..361	CDD:375054	39/165 (24%)
		OB_Dis3	381..447	CDD:436091	13/79 (16%)
		RNB	479..809	CDD:459934	132/349 (38%)
		Rrp44_S1	862..937	CDD:435792	18/75 (24%)